microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR7-1 Gene

Subcategory (RNA class) for MIR7-1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR7-1 Gene

  • MicroRNA 7-1 2 3 5
  • Hsa-MiR-7-1-3p 163 173
  • Hsa-MiR-7-5p 163 173
  • Hsa-Mir-7-1 2 3
  • MIR7-1 2 5
  • MIMAT0000252 50
  • MIMAT0004553 50
  • Hsa-Mir-7-P1 178
  • MI0000263 50
  • MiR-7-5p 3
  • MIRN7-1 3
  • Mir-7-1 3
  • RF00053 168

External Ids for MIR7-1 Gene

Previous HGNC Symbols for MIR7-1 Gene

  • MIRN7-1

Previous GeneCards Identifiers for MIR7-1 Gene

  • GC09M085776
  • GC09M086584
  • GC09M083970
  • GC09M083993

Summaries for MIR7-1 Gene

Entrez Gene Summary for MIR7-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-1 Gene

MIR7-1 (MicroRNA 7-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR7-1 include Pituitary Adenoma and Laryngeal Disease. Among its related pathways are Metabolism of proteins and Gene Expression.

Rfam classification for MIR7-1 Gene

Additional gene information for MIR7-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR7-1 Gene

Genomics for MIR7-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR7-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J083965 Enhancer 1 Ensembl ENCODE 0.7 +4.4 4350 1.6 ZNF629 ZNF692 POLR2A JUND PKNOX1 HDAC1 ZNF600 CEBPA EP300 CEBPB KIF27 ENSG00000233262 IDNK ENSG00000231616 MIR7-1 C9orf64 RMI1
GH09J083961 Enhancer 1 Ensembl ENCODE 0.4 +7.9 7856 2.4 CEBPG PRDM10 ZNF629 ZNF692 ZIC2 SP1 ZNF600 CEBPA ATF7 ZNF561 KIF27 ENSG00000233262 IDNK RMI1 C9orf64 MIR7-1
GH09J083959 Enhancer 0.7 Ensembl ENCODE 0.4 +10.7 10656 1.2 PRDM10 ZNF629 ZXDB ESR1 WT1 ZNF511 GTF3C2 JUND MAFK TEAD3 RMI1 HNRNPK KIF27 ENSG00000233262 C9orf64 MIR7-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR7-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR7-1 Gene

Genomic Locations for MIR7-1 Gene
chr9:83,969,748-83,969,857
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr9:86,584,663-86,584,772
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR7-1 Gene

Genes around MIR7-1 on UCSC Golden Path with GeneCards custom track
MIR7-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR7-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-1 Gene

Proteins for MIR7-1 Gene

Post-translational modifications for MIR7-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-1 Gene

Domains & Families for MIR7-1 Gene

Gene Families for MIR7-1 Gene

genes like me logo Genes that share domains with MIR7-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR7-1 Gene

Function for MIR7-1 Gene

Gene Ontology (GO) - Molecular Function for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR7-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-1 Gene

Localization for MIR7-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR7-1 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR7-1 Gene

Pathways & Interactions for MIR7-1 Gene

genes like me logo Genes that share pathways with MIR7-1: view

Pathways by source for MIR7-1 Gene

1 KEGG pathway for MIR7-1 Gene

Gene Ontology (GO) - Biological Process for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:1903671 negative regulation of sprouting angiogenesis IMP --
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR7-1 Gene

Drugs & Compounds for MIR7-1 Gene

No Compound Related Data Available

Transcripts for MIR7-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR7-1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000028D811_9606 miRNA 22 6

RefSeq: NR_029605,

LncBase: hsa-miR-7-1-3p,

miRBase: MIMAT0004553,

MirGeneDB: Hsa-Mir-7-P1_3p,

TarBase: hsa-miR-7-1-3p,

ENA: LM380232.1:1..22:ncRNA, LM608337.1:66..87:ncRNA,

URS00002C5007_9606 precursor_RNA 110 5

HGNC: 31638,

RefSeq: NR_029605,

Ensembl: ENST00000384871 (view in UCSC) ,

miRBase: MI0000263,

ENA: LM608337.1:1..110:precursor_RNA,

URS0000161522_9606 miRNA 24 3

RefSeq: NR_029605, NR_029606, NR_029607,

miRBase: MIMAT0000252,

MirGeneDB: Hsa-Mir-7-P1_5p, Hsa-Mir-7-P2_5p, Hsa-Mir-7-P3_5p,

URS0000591950_9606 miRNA 23 3

LncBase: hsa-miR-7-5p,

TarBase: hsa-miR-7-5p,

ENA: LM378893.1:1..23:ncRNA, LM608337.1:24..46:ncRNA, LM608338.1:32..54:ncRNA, LM608339.1:31..53:ncRNA,

URS000062CFAD_9606 precursor_RNA 91 1

Rfam: RF00053,

MIR7-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR7-1 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-1 Gene

No ASD Table

Relevant External Links for MIR7-1 Gene

GeneLoc Exon Structure for
MIR7-1

Expression for MIR7-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR7-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR7-1

genes like me logo Genes that share expression patterns with MIR7-1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7-1 Gene

Orthologs for MIR7-1 Gene

Evolution for MIR7-1 Gene

ENSEMBL:
Gene Tree for MIR7-1 (if available)
TreeFam:
Gene Tree for MIR7-1 (if available)

No data available for Orthologs for MIR7-1 Gene

Paralogs for MIR7-1 Gene

No data available for Paralogs for MIR7-1 Gene

Variants for MIR7-1 Gene

Additional dbSNP identifiers (rs#s) for MIR7-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR7-1 Gene

Variant ID Type Subtype PubMed ID
esv2759701 CNV gain 17122850
esv3620911 CNV gain 21293372
nsv1043703 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv469859 CNV gain 16826518
nsv831644 CNV gain 17160897
nsv8541 CNV gain 18304495
nsv972408 CNV duplication 23825009

Additional Variant Information for MIR7-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR7-1 Gene

Disorders for MIR7-1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR7-1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
laryngeal disease
  • laryngeal diseases
spermatogenic failure, y-linked, 2
  • spgfy2
bladder disease
  • urinary bladder disease
endocrine organ benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR7-1

genes like me logo Genes that share disorders with MIR7-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR7-1 Gene

Publications for MIR7-1 Gene

  1. microRNA-7 inhibition protects human osteoblasts from dexamethasone via activation of epidermal growth factor receptor signaling. (PMID: 31313024) Fan JB … Zhao JN (Molecular and cellular biochemistry 2019) 3
  2. MicroRNA-7 Exerts Antiangiogenic Effect on Colorectal Cancer via ERK Signaling. (PMID: 30909065) Fan X … Yuan S (The Journal of surgical research 2019) 3
  3. Upregulation of microRNA-7 contributes to inhibition of the growth and metastasis of osteosarcoma cells through the inhibition of IGF1R. (PMID: 31102265) Zhang Z … Wang G (Journal of cellular physiology 2019) 3
  4. Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation. (PMID: 31439810) Corral VM … Connell GJ (RNA (New York, N.Y.) 2019) 3
  5. MiR-7-5p suppresses stemness and enhances temozolomide sensitivity of drug-resistant glioblastoma cells by targeting Yin Yang 1. (PMID: 30586549) Jia B … Guo Q (Experimental cell research 2019) 3

Products for MIR7-1 Gene

Sources for MIR7-1 Gene