microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR7-1 Gene

RNA type for MIR7-1 Gene

miRNA

Aliases for MIR7-1 Gene

External Ids for MIR7-1 Gene

Previous HGNC Symbols for MIR7-1 Gene

  • MIRN7-1

Previous GeneCards Identifiers for MIR7-1 Gene

  • GC09M085776
  • GC09M086584
  • GC09M083970
  • GC09M083993
  • GC09M084057
  • GC09M084476

Summaries for MIR7-1 Gene

Entrez Gene Summary for MIR7-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-1 Gene

MIR7-1 (MicroRNA 7-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR7-1 include Pituitary Adenoma and Lung Large Cell Carcinoma. Among its related pathways are SUMOylation and MicroRNAs in cancer.

Rfam classification for MIR7-1 Gene

Additional gene information for MIR7-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR7-1 Gene

Genomics for MIR7-1 Gene

Genomic Locations for MIR7-1 Gene

Latest Assembly
chr9:83,969,748-83,969,857
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand

Previous Assembly
chr9:86,584,663-86,584,772
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR7-1 Gene

Genes around MIR7-1 on UCSC Golden Path with GeneCards custom track
MIR7-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR7-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-1 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR7-1 Gene

Proteins for MIR7-1 Gene

Post-translational modifications for MIR7-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-1 Gene

Domains & Families for MIR7-1 Gene

Gene Families for MIR7-1 Gene

genes like me logo Genes that share domains with MIR7-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR7-1 Gene

Function for MIR7-1 Gene

Gene Ontology (GO) - Molecular Function for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR7-1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-1 Gene

Localization for MIR7-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR7-1 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR7-1 Gene

Pathways & Interactions for MIR7-1 Gene

genes like me logo Genes that share pathways with MIR7-1: view

Pathways by source for MIR7-1 Gene

1 KEGG pathway for MIR7-1 Gene

Gene Ontology (GO) - Biological Process for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:1903671 negative regulation of sprouting angiogenesis IMP --
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR7-1 Gene

Drugs & Compounds for MIR7-1 Gene

No Compound Related Data Available

Transcripts for MIR7-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR7-1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000028D811_9606 miRNA 22 6

RefSeq: NR_029605,

LncBase: hsa-miR-7-1-3p,

miRBase: MIMAT0004553,

MirGeneDB: Hsa-Mir-7-P1_3p,

TarBase: hsa-miR-7-1-3p,

ENA: LM380232.1:1..22:ncRNA, LM608337.1:66..87:ncRNA,

URS00002C5007_9606 pre_miRNA 110 4

RefSeq: NR_029605,

Ensembl: ENST00000384871 (view in UCSC) ,

miRBase: MI0000263,

ENA: LM608337.1:1..110:precursor_RNA,

URS0000161522_9606 miRNA 24 3

RefSeq: NR_029605, NR_029606, NR_029607,

miRBase: MIMAT0000252,

MirGeneDB: Hsa-Mir-7-P1_5p, Hsa-Mir-7-P2_5p, Hsa-Mir-7-P3_5p,

URS0000591950_9606 miRNA 23 3

LncBase: hsa-miR-7-5p,

TarBase: hsa-miR-7-5p,

ENA: LM378893.1:1..23:ncRNA, LM608337.1:24..46:ncRNA, LM608338.1:32..54:ncRNA, LM608339.1:31..53:ncRNA,

URS000062CFAD_9606 pre_miRNA 91 1

Rfam: RF00053,

MIR7-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR7-1 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-1 Gene

No ASD Table

Relevant External Links for MIR7-1 Gene

GeneLoc Exon Structure for
MIR7-1

Expression for MIR7-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR7-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR7-1

genes like me logo Genes that share expression patterns with MIR7-1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7-1 Gene

Orthologs for MIR7-1 Gene

Evolution for MIR7-1 Gene

ENSEMBL:
Gene Tree for MIR7-1 (if available)
TreeFam:
Gene Tree for MIR7-1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR7-1

No data available for Orthologs for MIR7-1 Gene

Paralogs for MIR7-1 Gene

No data available for Paralogs for MIR7-1 Gene

Variants for MIR7-1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR7-1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR7-1 Gene

Variant ID Type Subtype PubMed ID
esv2759701 CNV gain 17122850
esv3620911 CNV gain 21293372
nsv1043703 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv469859 CNV gain 16826518
nsv831644 CNV gain 17160897
nsv8541 CNV gain 18304495
nsv972408 CNV duplication 23825009

Additional Variant Information for MIR7-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-1
Leiden Open Variation Database (LOVD)
MIR7-1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR7-1 Gene

Disorders for MIR7-1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR7-1 Gene - From: MID and COP

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
lung large cell carcinoma
  • large cell carcinoma of lung
laryngeal disease
  • laryngeal anomalies
spermatogenic failure, y-linked, 2
  • spgfy2
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR7-1

genes like me logo Genes that share disorders with MIR7-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR7-1 Gene

Publications for MIR7-1 Gene

  1. Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation. (PMID: 31347176) Pan M … Dou J (Journal of cellular physiology 2020) 3
  2. Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. (PMID: 32917870) Kristensen LS … Hager H (Nature communications 2020) 3
  3. Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis. (PMID: 31731190) Zheng Y … Xu S (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  4. Up-regulated lnc-lung cancer associated transcript 1 enhances cell migration and invasion in breast cancer progression. (PMID: 31635802) Li YL … Zhu SG (Biochemical and biophysical research communications 2020) 3
  5. MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma. (PMID: 32810522) Yang L … Teng CB (Biochimica et biophysica acta. Molecular cell research 2020) 3

Products for MIR7-1 Gene

Sources for MIR7-1 Gene