microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6886 Gene

Subcategory (RNA class) for MIR6886 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6886 Gene

  • MicroRNA 6886 2 3 5
  • Hsa-Mir-6886 2 3
  • MIR6886 2 5
  • MicroRNA Mir-6886 3
  • MIMAT0027673 50
  • MIMAT0027672 50
  • MI0022733 50

External Ids for MIR6886 Gene

Previous GeneCards Identifiers for MIR6886 Gene

  • GC19U901811

Summaries for MIR6886 Gene

Entrez Gene Summary for MIR6886 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6886 Gene

MIR6886 (MicroRNA 6886) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR6886 include Homozygous Familial Hypercholesterolemia. Among its related pathways are Lipoprotein metabolism and Clathrin-mediated endocytosis.

Additional gene information for MIR6886 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6886 Gene

Genomics for MIR6886 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6886 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011114 Enhancer 0.6 dbSUPER 600.7 +0.9 857 0.4 ZNF692 SP1 POLR2A ZNF316 RBM22 JUND NR2F2 SIN3A ZFP69B SUPT5H MIR6886 SPC24 piR-57460-346 LDLR
GH19J011111 Enhancer 0.5 dbSUPER 600.7 -1.8 -1763 0.5 RBFOX2 POLR2A RBM22 SMAD5 SUPT5H POLR2B MIR6886 piR-43107-137 LDLR SPC24
GH19J011113 Enhancer 0.4 dbSUPER 600.7 +0.0 4 0.9 POLR2A RBM22 SUPT5H MIR6886 TMEM205 piR-57460-346 LDLR SPC24
GH19J011115 Enhancer 0.5 dbSUPER 0.7 +3.0 2981 1.3 POLR2A RBM22 SUPT5H POLR2B PML SPC24 TMEM205 MIR6886 piR-57460-346 LDLR
GH19J011119 Enhancer 0.6 dbSUPER 0.4 +7.0 6970 1.6 IKZF1 RBFOX2 POLR2A EP300 FOXA2 ESRRA KDM1A RBM22 BCOR SUPT5H SPC24 piR-57460-346 MIR6886 LDLR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6886 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6886 Gene

Genomic Locations for MIR6886 Gene
chr19:11,113,474-11,113,534
(GRCh38/hg38)
Size:
61 bases
Orientation:
Plus strand

Genomic View for MIR6886 Gene

Genes around MIR6886 on UCSC Golden Path with GeneCards custom track
MIR6886 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6886 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6886 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6886 Gene

Proteins for MIR6886 Gene

Post-translational modifications for MIR6886 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6886 Gene

Domains & Families for MIR6886 Gene

Gene Families for MIR6886 Gene

HGNC:
genes like me logo Genes that share domains with MIR6886: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6886 Gene

Function for MIR6886 Gene

Phenotypes From GWAS Catalog for MIR6886 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6886 Gene

Localization for MIR6886 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6886 Gene

Pathways & Interactions for MIR6886 Gene

genes like me logo Genes that share pathways with MIR6886: view

Gene Ontology (GO) - Biological Process for MIR6886 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6886 Gene

Drugs & Compounds for MIR6886 Gene

No Compound Related Data Available

Transcripts for MIR6886 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6886 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A1D9_9606 precursor_RNA 61 4

HGNC: 50121,

RefSeq: NR_106946,

Ensembl: ENST00000619864 (view in UCSC) ,

miRBase: MI0022733,

URS000075D6A4_9606 miRNA 21 2

RefSeq: NR_106946,

miRBase: MIMAT0027673,

URS000075EF90_9606 miRNA 21 2

RefSeq: NR_106946,

miRBase: MIMAT0027672,

MIR6886 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6886 Gene

No ASD Table

Relevant External Links for MIR6886 Gene

GeneLoc Exon Structure for
MIR6886

No data available for mRNA/cDNA for MIR6886 Gene

Expression for MIR6886 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6886 Gene

Orthologs for MIR6886 Gene

Evolution for MIR6886 Gene

ENSEMBL:
Gene Tree for MIR6886 (if available)
TreeFam:
Gene Tree for MIR6886 (if available)

No data available for Orthologs for MIR6886 Gene

Paralogs for MIR6886 Gene

No data available for Paralogs for MIR6886 Gene

Variants for MIR6886 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6886 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
654906 Likely Pathogenic: Familial hypercholesterolemia 11,113,445(+) TGCAGGTGAGCGTCGC SPLICE_DONOR_VARIANT
rs1003723 Benign: Familial hypercholesterolemia 1 11,113,505(+) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs1131692206 Pathogenic: Familial hypercholesterolemia 1 11,113,510(+) A/G NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs139617694 Pathogenic/Likely Pathogenic: Familial hypercholesterolemia; Familial hypercholesterolemia 1; Homozygous familial hypercholesterolemia; Hypercholesterolaemia. Pathogenic/Likely Pathogenic: Familial hypercholesterolemia 1 11,113,534(+) G/AG/C SPLICE_ACCEPTOR_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1555805318 Uncertain Significance: Familial hypercholesterolemia 1 11,113,508(+) T/G NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR6886 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6886 Gene

Variant ID Type Subtype PubMed ID
nsv470126 CNV loss 18288195
nsv833751 CNV loss 17160897

Additional Variant Information for MIR6886 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6886

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6886 Gene

Disorders for MIR6886 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR6886 Gene - From: GeneCards

Disorder Aliases PubMed IDs
homozygous familial hypercholesterolemia
  • hofh
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR6886: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR6886 Gene

Publications for MIR6886 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6886 Gene

Sources for MIR6886 Gene