microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6883 Gene

Subcategory (RNA class) for MIR6883 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6883 Gene

  • MicroRNA 6883 2 3 5
  • Hsa-Mir-6883 2 3
  • MIR6883 2 5
  • MicroRNA Mir-6883 3
  • MIMAT0027666 50
  • MIMAT0027667 50
  • MI0022730 50

External Ids for MIR6883 Gene

Previous GeneCards Identifiers for MIR6883 Gene

  • GC17U902050
  • GC17M008179
  • GC17M008243
  • GC17M008592
  • GC17M008629
  • GC17M008674
  • GC17M008768
  • GC17M008250
  • GC17M008334
  • GC17M008365
  • GC17M008413
  • GC17M008445
  • GC17M008486
  • GC17M008519
  • GC17M008552

Summaries for MIR6883 Gene

Entrez Gene Summary for MIR6883 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6883 Gene

MIR6883 (MicroRNA 6883) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Melatonin metabolism and effects and Diurnally Regulated Genes with Circadian Orthologs.

Additional gene information for MIR6883 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6883 Gene

Genomics for MIR6883 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6883 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J008143 Enhancer 0.3 dbSUPER 600.7 +1.2 1223 0.9 BACH1 POLR2A MIR6883 lnc-VAMP2-4 lnc-VAMP2-3 PER1 HES7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6883 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6883 Gene

Genomic Locations for MIR6883 Gene
chr17:8,144,994-8,145,071
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR6883 Gene

Genes around MIR6883 on UCSC Golden Path with GeneCards custom track
MIR6883 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6883 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6883 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6883 Gene

Proteins for MIR6883 Gene

Post-translational modifications for MIR6883 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6883 Gene

Domains & Families for MIR6883 Gene

Gene Families for MIR6883 Gene

HGNC:
genes like me logo Genes that share domains with MIR6883: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6883 Gene

Function for MIR6883 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6883 Gene

Localization for MIR6883 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6883 Gene

Pathways & Interactions for MIR6883 Gene

genes like me logo Genes that share pathways with MIR6883: view

Gene Ontology (GO) - Biological Process for MIR6883 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6883 Gene

Drugs & Compounds for MIR6883 Gene

No Compound Related Data Available

Transcripts for MIR6883 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6883 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DF7D_9606 precursor_RNA 78 4

HGNC: 50019,

RefSeq: NR_106943,

Ensembl: ENST00000614952 (view in UCSC) ,

miRBase: MI0022730,

URS000075B504_9606 miRNA 22 2

RefSeq: NR_106943,

miRBase: MIMAT0027666,

URS000075E11F_9606 miRNA 22 2

RefSeq: NR_106943,

miRBase: MIMAT0027667,

MIR6883 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6883 Gene

No ASD Table

Relevant External Links for MIR6883 Gene

GeneLoc Exon Structure for
MIR6883

No data available for mRNA/cDNA for MIR6883 Gene

Expression for MIR6883 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6883 Gene

Orthologs for MIR6883 Gene

Evolution for MIR6883 Gene

ENSEMBL:
Gene Tree for MIR6883 (if available)
TreeFam:
Gene Tree for MIR6883 (if available)

No data available for Orthologs for MIR6883 Gene

Paralogs for MIR6883 Gene

No data available for Paralogs for MIR6883 Gene

Variants for MIR6883 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6883 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
710104 Benign: not provided 8,145,000(-) A/G NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR6883 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6883 Gene

Variant ID Type Subtype PubMed ID
nsv1964 CNV insertion 18451855
nsv457661 CNV loss 19166990
nsv516242 CNV loss 19592680
nsv518983 CNV loss 19592680
nsv527475 CNV loss 19592680
nsv574335 CNV loss 21841781
nsv833352 CNV loss 17160897

Additional Variant Information for MIR6883 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6883

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6883 Gene

Disorders for MIR6883 Gene

Additional Disease Information for MIR6883

No disorders were found for MIR6883 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6883 Gene

Publications for MIR6883 Gene

  1. miR-6883 Family miRNAs Target CDK4/6 to Induce G1 Phase Cell-Cycle Arrest in Colon Cancer Cells. (PMID: 29061672) Lulla AR … El-Deiry WS (Cancer research 2017) 3
  2. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6883 Gene

Sources for MIR6883 Gene