microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6868 Gene

Subcategory (RNA class) for MIR6868 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR6868 Gene

  • MicroRNA 6868 2 3 5
  • MicroRNA Mir-6868 3
  • Hsa-Mir-6868 3
  • MIMAT0027636 53
  • MIMAT0027637 53
  • MI0022715 53
  • MIR6868 2

External Ids for MIR6868 Gene

Previous GeneCards Identifiers for MIR6868 Gene

  • GC17U902070

Summaries for MIR6868 Gene

Entrez Gene Summary for MIR6868 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6868 Gene

MIR6868 (MicroRNA 6868) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6868 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6868 Gene

Genomics for MIR6868 Gene

GeneHancer (GH) Regulatory Elements for MIR6868 Gene

Promoters and enhancers for MIR6868 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076102 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 -5.8 -5756 2.9 SIN3A ZBTB40 RBPJ POLR2A NR2F6 CREB1 HCFC1 MYC ELF1 HLF lnc-ZACN-3 EXOC7 ENSG00000266980 UNK NUP85 MFSD11 NT5C SRP68 SRSF2 GGA3
GH17J076094 Enhancer 0.9 Ensembl ENCODE 0.6 +3.0 3046 0.9 SMARCE1 ZNF121 CBFA2T2 SP7 SMARCA4 DPF2 MTA2 HDAC2 FOSL1 NCOR1 SRSF2 NT5C METTL23 MFSD11 TEN1 ENSG00000266980 UNK NUP85 SNHG16 SPHK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6868 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6868 Gene

Genomic Locations for MIR6868 Gene
chr17:76,098,019-76,098,076
(GRCh38/hg38)
Size:
58 bases
Orientation:
Minus strand

Genomic View for MIR6868 Gene

Genes around MIR6868 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6868 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6868 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6868 Gene

Proteins for MIR6868 Gene

Post-translational modifications for MIR6868 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6868 Gene

Domains & Families for MIR6868 Gene

Gene Families for MIR6868 Gene

HGNC:
genes like me logo Genes that share domains with MIR6868: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6868 Gene

Function for MIR6868 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6868 Gene

Localization for MIR6868 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6868 Gene

Pathways & Interactions for MIR6868 Gene

PathCards logo

SuperPathways for MIR6868 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6868 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR6868 Gene

Drugs & Compounds for MIR6868 Gene

No Compound Related Data Available

Transcripts for MIR6868 Gene

mRNA/cDNA for MIR6868 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6868 Gene

No ASD Table

Relevant External Links for MIR6868 Gene

GeneLoc Exon Structure for
MIR6868
ECgene alternative splicing isoforms for
MIR6868

Expression for MIR6868 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6868 Gene:

MIR6868
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6868 Gene

Orthologs for MIR6868 Gene

Evolution for MIR6868 Gene

ENSEMBL:
Gene Tree for MIR6868 (if available)
TreeFam:
Gene Tree for MIR6868 (if available)

No data available for Orthologs for MIR6868 Gene

Paralogs for MIR6868 Gene

No data available for Paralogs for MIR6868 Gene

Variants for MIR6868 Gene

Sequence variations from dbSNP and Humsavar for MIR6868 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1002748551 -- 76,099,140(-) A/G upstream_transcript_variant
rs1003846231 -- 76,098,987(-) A/G upstream_transcript_variant
rs1004001906 -- 76,098,726(-) C/T upstream_transcript_variant
rs1005989293 -- 76,098,940(-) G/A/T upstream_transcript_variant
rs1007448751 -- 76,098,597(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6868 Gene

Variant ID Type Subtype PubMed ID
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Additional Variant Information for MIR6868 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6868

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6868 Gene

Disorders for MIR6868 Gene

Additional Disease Information for MIR6868

No disorders were found for MIR6868 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6868 Gene

Publications for MIR6868 Gene

  1. Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis. (PMID: 30486864) Wang Y … Chu X (Journal of experimental & clinical cancer research : CR 2018) 3 56
  2. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3 56
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR6868 Gene

Sources for MIR6868 Gene