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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6868 (MicroRNA 6868) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J076102 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.4 | -5.8 | -5756 | 2.9 | ARHGAP35 CREB1 PRDM10 ZNF629 TFE3 POLR2A ZNF692 ZHX2 FOXA1 MTA2 | lnc-ZACN-3 EXOC7 UNK SRSF2 ENSG00000267342 NUP85 GGA3 ENSG00000267546 ENSG00000266980 NT5C | |
GH17J076094 | Enhancer | 0.9 | Ensembl ENCODE | 0.7 | +3.0 | 3046 | 0.9 | JUND MTA2 DPF2 HMBOX1 HDAC2 NCOR1 FOSL1 PTBP1 BCOR ZNF395 | SRP68 ENSG00000279382 MIR6868 EXOC7 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075EE35_9606 | precursor_RNA | 58 | 4 |
HGNC: 50096, RefSeq: NR_106928, Ensembl: ENST00000611215 (view in UCSC) , miRBase: MI0022715, |
URS000075CE71_9606 | miRNA | 22 | 2 |
RefSeq: NR_106928, miRBase: MIMAT0027636, |
URS000075DF84_9606 | miRNA | 21 | 2 |
RefSeq: NR_106928, miRBase: MIMAT0027637, |
No disorders were found for MIR6868 Gene.