microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6866 Gene

Data sources for MIR6866 Gene:

Subcategory (RNA class) for MIR6866 Gene

miRNA

Aliases for MIR6866 Gene

External Ids for MIR6866 Gene

Previous GeneCards Identifiers for MIR6866 Gene

  • GC17U902036

Summaries for MIR6866 Gene

Entrez Gene Summary for MIR6866 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6866 Gene

MIR6866 (MicroRNA 6866) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination.

Additional gene information for MIR6866 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6866 Gene

Genomics for MIR6866 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6866 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040160 Enhancer 0.2 Ensembl 250.7 -1.8 -1832 0.2 MIR6866 MSL1 MED24 TOP2A CASC3 HSALNG0116327 RAPGEFL1
GH17J040151 Enhancer 1 Ensembl ENCODE 0.4 -9.3 -9333 3.2 IRF4 MAFF SMARCA5 RELA ZNF316 FOSL1 ZHX1 SPI1 NFE2 NFE2L2 MSL1 MED24 ENSG00000266208 MIR6866 CASC3 HSALNG0116327 RAPGEFL1
GH17J040158 Enhancer 0.6 Ensembl 0.7 -3.4 -3432 2.2 ZNF623 MAFF ZNF316 SPI1 MAFK REST NFE2 ZNF362 MAFG GLIS1 MED24 MSL1 MED1 TOP2A ENSG00000266208 MIR6866 CASC3 HSALNG0116327 RAPGEFL1
GH17J040146 Enhancer 0.3 Ensembl 0.4 -14.9 -14932 0.4 ATF2 CASC3 HSALNG0116327 MIR6866 RAPGEFL1
GH17J040148 Enhancer 0.2 Ensembl 0.4 -13.7 -13732 0.4 ENSG00000266208 CASC3 HSALNG0116327 MIR6866 RAPGEFL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6866 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6866 Gene

Latest Assembly
chr17:40,161,933-40,162,001
(GRCh38/hg38)
Size:
69 bases
Orientation:
Plus strand

Previous Assembly
chr17:38,318,186-38,318,254
(GRCh37/hg19 by Entrez Gene)
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR6866 Gene

Genes around MIR6866 on UCSC Golden Path with GeneCards custom track
MIR6866 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6866 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6866 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6866 Gene

Proteins for MIR6866 Gene

Post-translational modifications for MIR6866 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6866 Gene

Domains & Families for MIR6866 Gene

Gene Families for MIR6866 Gene

HGNC:
genes like me logo Genes that share domains with MIR6866: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6866 Gene

Function for MIR6866 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6866 Gene

Localization for MIR6866 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6866 Gene

Pathways & Interactions for MIR6866 Gene

genes like me logo Genes that share pathways with MIR6866: view

Gene Ontology (GO) - Biological Process for MIR6866 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6866 Gene

Drugs & Compounds for MIR6866 Gene

No Compound Related Data Available

Transcripts for MIR6866 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6866 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A88E_9606 pre_miRNA 69 3

RefSeq: NR_106926,

Ensembl: ENST00000638146 (view in UCSC) ,

miRBase: MI0022713,

URS000075CA93_9606 miRNA 23 2

RefSeq: NR_106926,

miRBase: MIMAT0027632,

URS000075E526_9606 miRNA 22 2

RefSeq: NR_106926,

miRBase: MIMAT0027633,

MIR6866 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6866 Gene

No ASD Table

Relevant External Links for MIR6866 Gene

GeneLoc Exon Structure for
MIR6866

No data available for mRNA/cDNA for MIR6866 Gene

Expression for MIR6866 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6866 Gene

Orthologs for MIR6866 Gene

Evolution for MIR6866 Gene

ENSEMBL:
Gene Tree for MIR6866 (if available)
TreeFam:
Gene Tree for MIR6866 (if available)

No data available for Orthologs for MIR6866 Gene

Paralogs for MIR6866 Gene

No data available for Paralogs for MIR6866 Gene

Variants for MIR6866 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6866 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6866 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv525796 CNV gain 19592680
nsv833444 CNV loss 17160897

Additional Variant Information for MIR6866 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6866

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6866 Gene

Disorders for MIR6866 Gene

Additional Disease Information for MIR6866

No disorders were found for MIR6866 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6866 Gene

Publications for MIR6866 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6866 Gene

Sources for MIR6866 Gene