microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6843 Gene

Subcategory (RNA class) for MIR6843 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6843 Gene

  • MicroRNA 6843 2 3 5
  • Hsa-Mir-6843 2 3
  • MIR6843 2 5
  • MicroRNA Mir-6843 3
  • MIMAT0027588 50
  • MI0022689 50

External Ids for MIR6843 Gene

Previous GeneCards Identifiers for MIR6843 Gene

  • GC08U901861

Summaries for MIR6843 Gene

Entrez Gene Summary for MIR6843 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6843 Gene

MIR6843 (MicroRNA 6843) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Creation of C4 and C2 activators.

Additional gene information for MIR6843 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6843 Gene

Genomics for MIR6843 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6843 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J027610 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -3.3 -3255 8.2 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 REST TFE3 LEF1 CLU FZD3 SCARA3 GULOP MIR6843 lnc-CLU-2 EPHX2
GH08J027607 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 0.7 +2.2 2167 1.6 RFX1 KDM1A ZIC2 RBFOX2 POLR2A ZNF239 ZNF341 ZNF316 ZSCAN5C OSR2 CCDC25 ESCO2 RNU6-1276P CLU MIR6843 RF00017-6910 EPHX2
GH08J027602 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 +7.4 7364 2.5 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 RFX1 SOX13 NFKBIZ RF00017-6910 ENSG00000253875 EPHX2 CHRNA2 CCDC25 ESCO2 RNU6-1276P GULOP MIR6843 CLU
GH08J027606 Enhancer 0.4 dbSUPER 0.7 +4.3 4263 0.8 ZNF23 ZBTB17 NR2C2 MAX CCDC25 ESCO2 RNU6-1276P GULOP RF00017-6910 MIR6843 CLU EPHX2
GH08J027604 Enhancer 0.3 dbSUPER 0.4 +5.5 5514 1 ZNF3 ZNF121 CLU RF00017-6910 MIR6843 EPHX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6843 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6843 Gene

Genomic Locations for MIR6843 Gene
chr8:27,610,601-27,610,751
(GRCh38/hg38)
Size:
151 bases
Orientation:
Minus strand

Genomic View for MIR6843 Gene

Genes around MIR6843 on UCSC Golden Path with GeneCards custom track
MIR6843 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6843 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6843 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6843 Gene

Proteins for MIR6843 Gene

Post-translational modifications for MIR6843 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6843 Gene

Domains & Families for MIR6843 Gene

Gene Families for MIR6843 Gene

HGNC:
genes like me logo Genes that share domains with MIR6843: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6843 Gene

Function for MIR6843 Gene

Phenotypes From GWAS Catalog for MIR6843 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6843 Gene

Localization for MIR6843 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6843 Gene

Pathways & Interactions for MIR6843 Gene

genes like me logo Genes that share pathways with MIR6843: view

Pathways by source for MIR6843 Gene

1 BioSystems pathway for MIR6843 Gene

Gene Ontology (GO) - Biological Process for MIR6843 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6843 Gene

Drugs & Compounds for MIR6843 Gene

No Compound Related Data Available

Transcripts for MIR6843 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6843 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A59F_9606 precursor_RNA 151 4

HGNC: 50240,

RefSeq: NR_106902,

Ensembl: ENST00000617673 (view in UCSC) ,

miRBase: MI0022689,

URS000075D3D1_9606 miRNA 21 2

RefSeq: NR_106902,

miRBase: MIMAT0027588,

MIR6843 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6843 Gene

No ASD Table

Relevant External Links for MIR6843 Gene

GeneLoc Exon Structure for
MIR6843

No data available for mRNA/cDNA for MIR6843 Gene

Expression for MIR6843 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6843 Gene

Orthologs for MIR6843 Gene

Evolution for MIR6843 Gene

ENSEMBL:
Gene Tree for MIR6843 (if available)
TreeFam:
Gene Tree for MIR6843 (if available)

No data available for Orthologs for MIR6843 Gene

Paralogs for MIR6843 Gene

No data available for Paralogs for MIR6843 Gene

Variants for MIR6843 Gene

Additional dbSNP identifiers (rs#s) for MIR6843 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6843 Gene

Variant ID Type Subtype PubMed ID
esv3572654 CNV loss 25503493
nsv610867 CNV gain 21841781
nsv831275 CNV loss 17160897

Additional Variant Information for MIR6843 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6843

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6843 Gene

Disorders for MIR6843 Gene

Additional Disease Information for MIR6843

No disorders were found for MIR6843 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6843 Gene

Publications for MIR6843 Gene

  1. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. (PMID: 24162737) Lambert JC … Amouyel P (Nature genetics 2013) 3
  2. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  3. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. (PMID: 19734903) Lambert JC … Amouyel P (Nature genetics 2009) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6843 Gene

Sources for MIR6843 Gene