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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6808 (MicroRNA 6808) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J001330 | Enhancer | 1 | Ensembl ENCODE | 0.4 | +7.9 | 7907 | 4 | HNRNPL ZBTB33 PRDM10 POLR2A ZIC2 RBFOX2 ZNF600 FUS ZNF341 ZFX | TAS1R3 ANKRD65 ATAD3B INTS11 SLC35E2A LINC01409 ENSG00000240731 LINC00115 ENSG00000227775 ENSG00000260179 | |
GH01J001337 | Enhancer | 0.6 | Ensembl dbSUPER | 0.7 | +2.0 | 2007 | 0.2 | GLIS1 SP1 SP3 KLF1 | ANKRD65 MIR6808 TAS1R3 DVL1 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.69
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2 | WNT mediated activation of DVL | ||
3 | Signaling by Rho GTPases | ||
4 | Signaling by Wnt |
.71
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5 | Wnt Signaling Pathway and Pluripotency |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075F035_9606 | precursor_RNA | 59 | 4 |
HGNC: 50046, RefSeq: NR_106866, Ensembl: ENST00000616525 (view in UCSC) , miRBase: MI0022653, |
URS000075A409_9606 | miRNA | 22 | 2 |
RefSeq: NR_106866, miRBase: MIMAT0027516, |
URS0000759DC1_9606 | miRNA | 21 | 2 |
RefSeq: NR_106866, miRBase: MIMAT0027517, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv26n54 | CNV | loss | 21841781 |
dgv27n54 | CNV | gain | 21841781 |
dgv2n67 | CNV | gain | 20364138 |
dgv6n100 | CNV | gain+loss | 25217958 |
dgv7n100 | CNV | loss | 25217958 |
esv2758912 | CNV | loss | 17122850 |
esv3890636 | CNV | loss | 25118596 |
nsv1000169 | CNV | gain | 25217958 |
nsv1009541 | CNV | gain | 25217958 |
nsv10161 | CNV | gain+loss | 18304495 |
nsv1160788 | CNV | deletion | 26073780 |
nsv470680 | CNV | loss | 18288195 |
nsv482937 | CNV | loss | 15286789 |
nsv544969 | CNV | loss | 21841781 |
nsv544971 | CNV | loss | 21841781 |
nsv544977 | CNV | gain+loss | 21841781 |
nsv950452 | CNV | deletion | 24416366 |
nsv997291 | CNV | gain | 25217958 |
No disorders were found for MIR6808 Gene.