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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6778 (MicroRNA 6778) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are One carbon pool by folate and Viral mRNA Translation.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J018339 | Enhancer | 0.2 | FANTOM5 | 250.7 | +1.4 | 1438 | 0.1 | MIR6778 piR-32677-192 piR-46662-276 piR-43099-245 piR-43583-219 piR-45471-247 piR-50308-266 piR-54764-272 piR-55650-280 piR-55655-234 | ||
GH17J018342 | Enhancer | 0.2 | Ensembl | 250.7 | -1.6 | -1615 | 0.2 | MIR6778 RF00017-2305 lnc-TOP3A-1 SHMT1 SMCR8 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of water-soluble vitamins and cofactors | ||
2 | Valine, leucine and isoleucine degradation | ||
3 | One carbon pool by folate | ||
4 | Metabolism |
.40
|
|
5 | Viral mRNA Translation |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075E4AA_9606 | precursor_RNA | 73 | 3 |
RefSeq: NR_106836, Ensembl: ENST00000617912 (view in UCSC) , miRBase: MI0022623, |
URS000075B2C3_9606 | miRNA | 22 | 2 |
RefSeq: NR_106836, miRBase: MIMAT0027456, |
URS000075C1BB_9606 | miRNA | 21 | 2 |
RefSeq: NR_106836, miRBase: MIMAT0027457, |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs377036954 | Likely Benign: not provided | 18,340,819(-) |
G/C NM_004169.5(SHMT1):c.520-6C>G |
NON_CODING_TRANSCRIPT_VARIANT,INTRON |
No disorders were found for MIR6778 Gene.