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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR6778 Gene
Subcategory (RNA class) for MIR6778 Gene
miRNA
Number of RNA Genes sources:
1 / 17
Aliases for MIR6778 Gene
External Ids for MIR6778 Gene
- HGNC: 50183
- Entrez Gene: 102466733
- Ensembl: ENSG00000283772
Additional External Ids for MIR6778 Gene
- Ensembl:
Previous GeneCards Identifiers for MIR6778 Gene
- GC17U902073
- GC17M018345
- GC17M018349
- GC17M018350
- GC17M018352
- GC17M019462
- GC17M018347
Summaries for MIR6778 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR6778 Gene
MIR6778 (MicroRNA 6778) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are One carbon pool by folate and Valine, leucine and isoleucine degradation.
Additional gene information for MIR6778 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6778 Gene
Genomics for MIR6778 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR6778 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J018339 | Enhancer | 0.2 | FANTOM5 | 600.7 | +1.4 | 1438 | 0.1 | MIR6778 piR-32677-192 piR-55650-280 piR-45471-247 piR-55655-234 piR-56022-216 piR-43099-245 piR-46662-276 piR-50308-266 piR-43583-219 | ||
| GH17J018342 | Enhancer | 0.2 | Ensembl | 600.7 | -1.6 | -1615 | 0.2 | RF00017-2305 MIR6778 lnc-TOP3A-1 SHMT1 SMCR8 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR6778 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR6778 Gene
Genomic Locations for MIR6778 Gene
- chr17:18,340,814-18,340,886
- (GRCh38/hg38)
- Size:
- 73 bases
- Orientation:
- Minus strand
Genomic View for MIR6778 Gene
Genes around MIR6778 on UCSC Golden Path with GeneCards custom track
MIR6778 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
MIR6778 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR6778 Gene
Proteins for MIR6778 Gene
Post-translational modifications for MIR6778 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR6778
- Origene Custom Protein Services for MIR6778
No data available for DME Specific Peptides for MIR6778 Gene
Domains & Families for MIR6778 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6778 Gene
Function for MIR6778 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6778 Gene
Localization for MIR6778 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6778 Gene
Pathways & Interactions for MIR6778 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of water-soluble vitamins and cofactors | ||
| 2 | Valine, leucine and isoleucine degradation | ||
| 3 | One carbon pool by folate | ||
| 4 | Metabolism |
.40
|
|
| 5 | Viral mRNA Translation | ||
Pathways by source for MIR6778 Gene
3 BioSystems pathways for MIR6778 Gene
7 Reactome pathways for MIR6778 Gene
No data available for Interacting Proteins and SIGNOR curated interactions for MIR6778 Gene
Transcripts for MIR6778 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6778 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075E4AA_9606 | precursor_RNA | 73 | 4 |
HGNC: 50183, RefSeq: NR_106836, Ensembl: ENST00000617912 (view in UCSC) , ENST00000638760 (view in UCSC) , miRBase: MI0022623, |
| URS000075B2C3_9606 | miRNA | 22 | 2 |
RefSeq: NR_106836, miRBase: MIMAT0027456, |
| URS000075C1BB_9606 | miRNA | 21 | 2 |
RefSeq: NR_106836, miRBase: MIMAT0027457, |
MIR6778 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
CRISPR Products
- Browse CRISPR knockouts for MIR6778
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for MIR6778 Gene
- GeneLoc Exon Structure for
- MIR6778
No data available for mRNA/cDNA for MIR6778 Gene
Expression for MIR6778 Gene
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIR6778
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6778 Gene
Orthologs for MIR6778 Gene
No data available for Orthologs for MIR6778 Gene
Paralogs for MIR6778 Gene
No data available for Paralogs for MIR6778 Gene
Variants for MIR6778 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6778 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 740690 | Likely Benign: not provided | 18,340,819(-) | G/C | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
Additional Variant Information for MIR6778 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR6778
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6778 Gene
Disorders for MIR6778 Gene
Additional Disease Information for MIR6778
No disorders were found for MIR6778 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6778 Gene
Publications for MIR6778 Gene
- CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer. (PMID: 31438886) Li H … Li Q (BMC cancer 2019) 3
- Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
ExternalLinks
Products for MIR6778 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR6778
- Origene Custom Protein Services for MIR6778
- Browse OriGene Inhibitory RNA Products For MIR6778
- OriGene qPCR primer pairs for MIR6778
- Browse CRISPR knockouts for MIR6778
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR6778
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR6778
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR6778
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR6778
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR6778
Sources for MIR6778 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB