MIR6778 Gene (RNA Gene)

MicroRNA 6778

GC17M020228
GIFtS:
8
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6778 Gene

Data sources for MIR6778 Gene:

Subcategory (RNA class) for MIR6778 Gene

miRNA

Aliases for MIR6778 Gene

External Ids for MIR6778 Gene

Previous GeneCards Identifiers for MIR6778 Gene

  • GC17U902073
  • GC17M018345
  • GC17M018349
  • GC17M018350
  • GC17M018352
  • GC17M019462
  • GC17M018347
  • GC17M019863

Summaries for MIR6778 Gene

Entrez Gene Summary for MIR6778 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6778 Gene

MIR6778 (MicroRNA 6778) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are One carbon pool by folate and Viral mRNA Translation.

Additional gene information for MIR6778 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6778 Gene

Genomics for MIR6778 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR6778 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J018339 Enhancer 0.2 FANTOM5 250.7 +1.4 1438 0.1 MIR6778 piR-32677-192 piR-46662-276 piR-43099-245 piR-43583-219 piR-45471-247 piR-50308-266 piR-54764-272 piR-55650-280 piR-55655-234
GH17J018342 Enhancer 0.2 Ensembl 250.7 -1.6 -1615 0.2 MIR6778 RF00017-2305 lnc-TOP3A-1 SHMT1 SMCR8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6778 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6778 Gene

Latest Assembly
chr17:18,340,814-18,340,886
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand

Previous Assembly
chr17:18,244,128-18,244,200
(GRCh37/hg19 by Entrez Gene)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR6778 Gene

Genes around MIR6778 on UCSC Golden Path with GeneCards custom track
MIR6778 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6778 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6778 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR6778 Gene

Proteins for MIR6778 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

Post-translational modifications for MIR6778 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6778 Gene

Domains & Families for MIR6778 Gene

Gene Families for MIR6778 Gene

HGNC:
genes like me logo Genes that share domains with MIR6778: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6778 Gene

Function for MIR6778 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6778 Gene

Localization for MIR6778 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6778 Gene

Pathways & Interactions for MIR6778 Gene

genes like me logo Genes that share pathways with MIR6778: view

Gene Ontology (GO) - Biological Process for MIR6778 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6778 Gene

Drugs & Compounds for MIR6778 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for MIR6778 Gene

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Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6778 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E4AA_9606 precursor_RNA 73 3

RefSeq: NR_106836,

Ensembl: ENST00000617912 (view in UCSC) ,

miRBase: MI0022623,

URS000075B2C3_9606 miRNA 22 2

RefSeq: NR_106836,

miRBase: MIMAT0027456,

URS000075C1BB_9606 miRNA 21 2

RefSeq: NR_106836,

miRBase: MIMAT0027457,

MIR6778 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6778 Gene

No ASD Table

Relevant External Links for MIR6778 Gene

GeneLoc Exon Structure for
MIR6778

No data available for mRNA/cDNA for MIR6778 Gene

Expression for MIR6778 Gene

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  2. Gene Expression Assays for research
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6778 Gene

Orthologs for MIR6778 Gene

Evolution for MIR6778 Gene

ENSEMBL:
Gene Tree for MIR6778 (if available)
TreeFam:
Gene Tree for MIR6778 (if available)

No data available for Orthologs for MIR6778 Gene

Paralogs for MIR6778 Gene

No data available for Paralogs for MIR6778 Gene

Variants for MIR6778 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6778 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs377036954 Likely Benign: not provided 18,340,819(-) G/C
NM_004169.5(SHMT1):c.520-6C>G 		NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6778 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6778 Gene

Variant ID Type Subtype PubMed ID
esv2758677 CNV gain+loss 17122850
nsv155 OTHER inversion 15895083
nsv428333 CNV gain 18775914
nsv499114 OTHER inversion 21111241
nsv509653 CNV insertion 20534489
nsv833386 CNV gain 17160897
nsv833387 CNV loss 17160897

Additional Variant Information for MIR6778 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6778

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6778 Gene

Disorders for MIR6778 Gene

Additional Disease Information for MIR6778

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR6778 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6778 Gene

Publications for MIR6778 Gene

  1. Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism. (PMID: 32142918) Zhao M … Liu M (Cancer letters 2020) 3
  2. CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer. (PMID: 31438886) Li H … Li Q (BMC cancer 2019) 3
  3. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

ExternalLinks

View latest publications for MIR6778 gene in Mastermind

Products for MIR6778 Gene

Sources for MIR6778 Gene