microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6775 Gene

Subcategory (RNA class) for MIR6775 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6775 Gene

  • MicroRNA 6775 2 3 5
  • Hsa-Mir-6775 2 3
  • MIR6775 2 5
  • MicroRNA Mir-6775 3
  • MIMAT0027451 50
  • MIMAT0027450 50
  • MI0022620 50

External Ids for MIR6775 Gene

Previous GeneCards Identifiers for MIR6775 Gene

  • GC16U901794

Summaries for MIR6775 Gene

Entrez Gene Summary for MIR6775 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6775 Gene

MIR6775 (MicroRNA 6775) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6775 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6775 Gene

Genomics for MIR6775 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6775 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J087834 Enhancer 1.1 Ensembl ENCODE dbSUPER 600.7 -0.4 -441 1.4 HNRNPL CREB1 TARDBP RBFOX2 ZNF600 SP1 CTBP1 POLR2A ZNF444 ESRRA ENSG00000260466 MIR6775 SLC7A5 ENSG00000205037 LOC107987237 KLHDC4
GH16J087832 Enhancer 0.9 Ensembl ENCODE dbSUPER 600.7 +1.5 1459 0.8 RBFOX2 SCRT2 POLR2A RBM22 SCRT1 PCBP1 SPI1 SIN3A SP1 MIR6775 RF00017-2189 LOC107987237 SLC7A5 KLHDC4
GH16J087830 Enhancer 0.8 Ensembl dbSUPER 0.7 +4.2 4159 0.6 TEAD4 ZNF692 SCRT2 MTA3 RBM22 POLR2A ZFP69B SIN3A SUPT5H SREBF1 RF00017-2189 MIR6775 LOC107987237 SLC7A5 KLHDC4
GH16J087831 Enhancer 0.7 Ensembl dbSUPER 0.7 +3.3 3259 0.8 RFX1 ZNF692 POLR2A MTA3 RBM22 GABPB1 ZFP69B SIN3A SUPT5H SREBF1 RF00017-2189 MIR6775 LOC107987237 SLC7A5 KLHDC4
GH16J087828 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 +5.9 5859 2.4 PRDM10 ZNF692 POLR2A ZNF24 SCRT2 CEBPB CHD2 MTA3 TCF12 RBM22 SLC7A5 ENSG00000205037 RF00017-2189 MIR6775 LOC107987237 KLHDC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6775 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6775 Gene

Genomic Locations for MIR6775 Gene
chr16:87,834,592-87,834,660
(GRCh38/hg38)
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR6775 Gene

Genes around MIR6775 on UCSC Golden Path with GeneCards custom track
MIR6775 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6775 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6775 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6775 Gene

Proteins for MIR6775 Gene

Post-translational modifications for MIR6775 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6775 Gene

Domains & Families for MIR6775 Gene

Gene Families for MIR6775 Gene

HGNC:
genes like me logo Genes that share domains with MIR6775: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6775 Gene

Function for MIR6775 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6775 Gene

Localization for MIR6775 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6775 Gene

Pathways & Interactions for MIR6775 Gene

PathCards logo

SuperPathways for MIR6775 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6775 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6775 Gene

Drugs & Compounds for MIR6775 Gene

No Compound Related Data Available

Transcripts for MIR6775 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6775 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DEA5_9606 precursor_RNA 69 4

HGNC: 50100,

RefSeq: NR_106833,

Ensembl: ENST00000617557 (view in UCSC) ,

miRBase: MI0022620,

URS0000759DC2_9606 miRNA 25 2

RefSeq: NR_106833,

miRBase: MIMAT0027450,

URS000075A8B6_9606 miRNA 21 2

RefSeq: NR_106833,

miRBase: MIMAT0027451,

MIR6775 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6775 Gene

No ASD Table

Relevant External Links for MIR6775 Gene

GeneLoc Exon Structure for
MIR6775

No data available for mRNA/cDNA for MIR6775 Gene

Expression for MIR6775 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6775 Gene

Orthologs for MIR6775 Gene

Evolution for MIR6775 Gene

ENSEMBL:
Gene Tree for MIR6775 (if available)
TreeFam:
Gene Tree for MIR6775 (if available)

No data available for Orthologs for MIR6775 Gene

Paralogs for MIR6775 Gene

No data available for Paralogs for MIR6775 Gene

Variants for MIR6775 Gene

Additional dbSNP identifiers (rs#s) for MIR6775 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6775 Gene

Variant ID Type Subtype PubMed ID
dgv3062n100 CNV loss 25217958
dgv36n68 CNV loss 17160897
esv3892935 CNV loss 25118596
nsv1059786 CNV gain 25217958
nsv1062946 CNV gain 25217958
nsv1160441 CNV deletion 26073780
nsv457616 CNV gain 19166990
nsv573536 CNV gain 21841781
nsv573557 CNV loss 21841781
nsv833322 CNV loss 17160897

Additional Variant Information for MIR6775 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6775

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6775 Gene

Disorders for MIR6775 Gene

No disorders were found for MIR6775 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6775 Gene

Publications for MIR6775 Gene

  1. Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins. (PMID: 30333480) Meng L … Sang M (Cell death & disease 2018) 3
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  3. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6775 Gene

Sources for MIR6775 Gene