microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6769B Gene

Subcategory (RNA class) for MIR6769B Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR6769B Gene

  • MicroRNA 6769b 2 3 5
  • MicroRNA Mir-6769b 3
  • Hsa-Mir-6769b 3
  • MIMAT0027620 53
  • MIMAT0027621 53
  • MI0022706 53
  • MIR6769B 2

External Ids for MIR6769B Gene

Previous GeneCards Identifiers for MIR6769B Gene

  • GC01U904035

Summaries for MIR6769B Gene

Entrez Gene Summary for MIR6769B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6769B Gene

MIR6769B (MicroRNA 6769b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6769B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6769B Gene

Genomics for MIR6769B Gene

GeneHancer (GH) Regulatory Elements for MIR6769B Gene

Promoters and enhancers for MIR6769B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206474 Enhancer 0.2 Ensembl 750.6 -0.3 -302 0.2 MIR6769B IKBKE NONHSAG004090.2
GH01J206469 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.6 -3.3 -3328 4.2 SMARCE1 POLR2A TCF7L2 MYC ELF1 RELA MAX MNT ZNF652 NKRF IKBKE NONHSAG004090.2 RASSF5 MAPKAPK2 MIR6769B RF00017-457
GH01J206479 Enhancer 0.6 ENCODE 0.6 +4.9 4890 0.2 CTCF CC2D1A RAD21 GLIS2 REST PRDM10 TRIM22 ZNF143 RUNX3 ZC3H8 NONHSAG004091.2 MIR6769B IKBKE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6769B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6769B Gene

Genomic Locations for MIR6769B Gene
chr1:206,474,803-206,474,864
(GRCh38/hg38)
Size:
62 bases
Orientation:
Plus strand

Genomic View for MIR6769B Gene

Genes around MIR6769B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6769B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6769B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6769B Gene

Proteins for MIR6769B Gene

Post-translational modifications for MIR6769B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6769B Gene

Domains & Families for MIR6769B Gene

Gene Families for MIR6769B Gene

HGNC:
genes like me logo Genes that share domains with MIR6769B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6769B Gene

Function for MIR6769B Gene

Phenotypes From GWAS Catalog for MIR6769B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6769B Gene

Localization for MIR6769B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6769B Gene

Pathways & Interactions for MIR6769B Gene

PathCards logo

SuperPathways for MIR6769B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6769B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR6769B Gene

Drugs & Compounds for MIR6769B Gene

No Compound Related Data Available

Transcripts for MIR6769B Gene

mRNA/cDNA for MIR6769B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6769B Gene

No ASD Table

Relevant External Links for MIR6769B Gene

GeneLoc Exon Structure for
MIR6769B
ECgene alternative splicing isoforms for
MIR6769B

Expression for MIR6769B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6769B Gene:

MIR6769B
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6769B Gene

Orthologs for MIR6769B Gene

Evolution for MIR6769B Gene

ENSEMBL:
Gene Tree for MIR6769B (if available)
TreeFam:
Gene Tree for MIR6769B (if available)

No data available for Orthologs for MIR6769B Gene

Paralogs for MIR6769B Gene

No data available for Paralogs for MIR6769B Gene

Variants for MIR6769B Gene

Sequence variations from dbSNP and Humsavar for MIR6769B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000417815 -- 206,474,199(+) C/G/T upstream_transcript_variant
rs1000749477 -- 206,475,223(+) T/C downstream_transcript_variant
rs1001640842 -- 206,474,597(+) T/A upstream_transcript_variant
rs1006540028 -- 206,473,976(+) A/G upstream_transcript_variant
rs1009801969 -- 206,475,350(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6769B Gene

Variant ID Type Subtype PubMed ID
dgv564n100 CNV gain 25217958
nsv549068 CNV gain 21841781

Additional Variant Information for MIR6769B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6769B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6769B Gene

Disorders for MIR6769B Gene

Additional Disease Information for MIR6769B

No disorders were found for MIR6769B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6769B Gene

Publications for MIR6769B Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR6769B Gene

Sources for MIR6769B Gene