microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6761 Gene

Subcategory (RNA class) for MIR6761 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6761 Gene

  • MicroRNA 6761 2 3 5
  • Hsa-Mir-6761 2 3
  • MIR6761 2 5
  • MicroRNA Mir-6761 3
  • MIMAT0027423 50
  • MIMAT0027422 50
  • MI0022606 50

External Ids for MIR6761 Gene

Previous GeneCards Identifiers for MIR6761 Gene

  • GC12U901959

Summaries for MIR6761 Gene

Entrez Gene Summary for MIR6761 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6761 Gene

MIR6761 (MicroRNA 6761) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6761 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6761 Gene

Genomics for MIR6761 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6761 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J111766 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -32.4 -32362 3.3 ZBTB33 PRDM10 IKZF1 NFKBIZ ZNF692 RCOR2 JUND MTA2 ZIC2 RBFOX2 ALDH2 ATXN2 ADAM1A HECTD4 ENSG00000257767 MIR6761 MAPKAPK5
GH12J111772 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.4 -24.1 -24090 6.2 SP1 GATAD2A PRDM10 REST TFE3 LEF1 IKZF1 NFKBIZ POLR2A BACH1 ALDH2 ACAD10 BRAP SH2B3 PHETA1 ENSG00000257767 MIR6761 MAPKAPK5
GH12J111788 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -11.2 -11233 0.8 GATAD2A CTCF PRDM10 REST ZNF143 ZNF776 ZIC2 RAD21 SP1 TRIM22 ADAM1A ALDH2 ACAD10 BRAP MIR6761 ENSG00000257767 MAPKAPK5
GH12J111787 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -12.3 -12331 0.2 GATAD2A RXRB IRF2 SP1 GABPA CEBPA SOX13 FOXA2 YY1 TEAD1 ALDH2 ACAD10 BRAP MIR6761 ENSG00000257767 MAPKAPK5
GH12J111791 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -7.8 -7806 1.9 JUND SP1 ATF3 YY1 ZBTB33 FOSL1 NR2F2 RAD21 CREM HNF4A ALDH2 MIR6761 ENSG00000257767 MAPKAPK5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6761 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6761 Gene

Genomic Locations for MIR6761 Gene
chr12:111,799,834-111,799,905
(GRCh38/hg38)
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR6761 Gene

Genes around MIR6761 on UCSC Golden Path with GeneCards custom track
MIR6761 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6761 Gene

Proteins for MIR6761 Gene

Post-translational modifications for MIR6761 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6761 Gene

Domains & Families for MIR6761 Gene

Gene Families for MIR6761 Gene

HGNC:
genes like me logo Genes that share domains with MIR6761: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6761 Gene

Function for MIR6761 Gene

Phenotypes From GWAS Catalog for MIR6761 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6761 Gene

Localization for MIR6761 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6761 Gene

Pathways & Interactions for MIR6761 Gene

PathCards logo

SuperPathways for MIR6761 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6761 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6761 Gene

Drugs & Compounds for MIR6761 Gene

No Compound Related Data Available

Transcripts for MIR6761 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6761 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A724_9606 precursor_RNA 72 4

HGNC: 49949,

RefSeq: NR_106819,

Ensembl: ENST00000617899 (view in UCSC) ,

miRBase: MI0022606,

URS000075BA43_9606 miRNA 22 2

RefSeq: NR_106819,

miRBase: MIMAT0027423,

URS0000759C5F_9606 miRNA 21 2

RefSeq: NR_106819,

miRBase: MIMAT0027422,

MIR6761 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6761 Gene

No ASD Table

Relevant External Links for MIR6761 Gene

GeneLoc Exon Structure for
MIR6761

No data available for mRNA/cDNA for MIR6761 Gene

Expression for MIR6761 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6761 Gene

Orthologs for MIR6761 Gene

Evolution for MIR6761 Gene

ENSEMBL:
Gene Tree for MIR6761 (if available)
TreeFam:
Gene Tree for MIR6761 (if available)

No data available for Orthologs for MIR6761 Gene

Paralogs for MIR6761 Gene

No data available for Paralogs for MIR6761 Gene

Variants for MIR6761 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6761 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
728511 Likely Benign: not provided 111,799,896(+) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR6761 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6761 Gene

Variant ID Type Subtype PubMed ID
dgv1556n100 CNV gain 25217958
dgv2874n54 CNV gain 21841781
dgv304e214 CNV gain 21293372
dgv514e212 CNV gain 25503493
esv2760710 CNV gain 21179565
nsv455715 CNV gain 19166990
nsv470317 CNV gain 18288195
nsv515716 CNV gain 19592680

Additional Variant Information for MIR6761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6761

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6761 Gene

Disorders for MIR6761 Gene

Additional Disease Information for MIR6761

No disorders were found for MIR6761 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6761 Gene

Publications for MIR6761 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6761 Gene

Sources for MIR6761 Gene