microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6759 Gene

Subcategory (RNA class) for MIR6759 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6759 Gene

  • MicroRNA 6759 2 3 5
  • Hsa-Mir-6759 2 3
  • MIR6759 2 5
  • MicroRNA Mir-6759 3
  • MIMAT0027419 50
  • MIMAT0027418 50
  • MI0022604 50

External Ids for MIR6759 Gene

Previous GeneCards Identifiers for MIR6759 Gene

  • GC12U901876

Summaries for MIR6759 Gene

Entrez Gene Summary for MIR6759 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6759 Gene

MIR6759 (MicroRNA 6759) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6759 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6759 Gene

Genomics for MIR6759 Gene

Genomic Locations for MIR6759 Gene

Genomic Locations for MIR6759 Gene
chr12:57,748,618-57,748,682
(GRCh38/hg38)
Size:
65 bases
Orientation:
Minus strand

Genomic View for MIR6759 Gene

Genes around MIR6759 on UCSC Golden Path with GeneCards custom track
MIR6759 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6759 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6759 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6759 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR6759 Gene

Proteins for MIR6759 Gene

Post-translational modifications for MIR6759 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6759 Gene

Domains & Families for MIR6759 Gene

Gene Families for MIR6759 Gene

HGNC:
genes like me logo Genes that share domains with MIR6759: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6759 Gene

Function for MIR6759 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6759 Gene

Localization for MIR6759 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6759 Gene

Pathways & Interactions for MIR6759 Gene

PathCards logo

SuperPathways for MIR6759 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6759 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6759 Gene

Drugs & Compounds for MIR6759 Gene

No Compound Related Data Available

Transcripts for MIR6759 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6759 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DB36_9606 precursor_RNA 65 4

HGNC: 50063,

RefSeq: NR_106817,

Ensembl: ENST00000638110 (view in UCSC) ,

miRBase: MI0022604,

URS000075A5C0_9606 miRNA 22 2

RefSeq: NR_106817,

miRBase: MIMAT0027418,

URS000075B2EE_9606 miRNA 22 2

RefSeq: NR_106817,

miRBase: MIMAT0027419,

MIR6759 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6759 Gene

No ASD Table

Relevant External Links for MIR6759 Gene

GeneLoc Exon Structure for
MIR6759

No data available for mRNA/cDNA for MIR6759 Gene

Expression for MIR6759 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6759 Gene

Orthologs for MIR6759 Gene

Evolution for MIR6759 Gene

ENSEMBL:
Gene Tree for MIR6759 (if available)
TreeFam:
Gene Tree for MIR6759 (if available)

No data available for Orthologs for MIR6759 Gene

Paralogs for MIR6759 Gene

No data available for Paralogs for MIR6759 Gene

Variants for MIR6759 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6759 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
827505 Uncertain Significance: Hereditary cancer-predisposing syndrome 57,748,621(-) A/G NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs1555201035 Uncertain Significance: Hereditary cutaneous melanoma 57,748,621(-) AG/A NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR6759 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6759 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv826384 CNV gain 20364138
nsv826386 CNV gain 20364138

Additional Variant Information for MIR6759 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6759

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6759 Gene

Disorders for MIR6759 Gene

Additional Disease Information for MIR6759

No disorders were found for MIR6759 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6759 Gene

Publications for MIR6759 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6759 Gene

Sources for MIR6759 Gene