microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6758 Gene

Data sources for MIR6758 Gene:

RNA type for MIR6758 Gene

miRNA

Aliases for MIR6758 Gene

External Ids for MIR6758 Gene

Previous GeneCards Identifiers for MIR6758 Gene

  • GC12U901933

Summaries for MIR6758 Gene

Entrez Gene Summary for MIR6758 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6758 Gene

MIR6758 (MicroRNA 6758) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR6758 include Charcot-Marie-Tooth Disease, Axonal, Type 2U and Interstitial Lung And Liver Disease. Among its related pathways are Viral mRNA Translation and tRNA Aminoacylation.

Additional gene information for MIR6758 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6758 Gene

Genomics for MIR6758 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6758 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057511 Enhancer 0.5 dbSUPER 250.7 -0.4 -397 2.3 POLR2A SUPT5H REST ZBTB33 EGR2 ZFHX2 SCRT2 HSALNG0091629 MN309568 MIR6758 RF00026-236 lnc-MBD6-1 DCTN2 EEF1AKMT3 ENSG00000285133 HSALNG0091628 ARHGAP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6758 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6758 Gene

Latest Assembly
chr12:57,512,688-57,512,750
(GRCh38/hg38)
Size:
63 bases
Orientation:
Plus strand

Previous Assembly
chr12:57,906,471-57,906,533
(GRCh37/hg19 by Entrez Gene)
Size:
63 bases
Orientation:
Plus strand

Genomic View for MIR6758 Gene

Genes around MIR6758 on UCSC Golden Path with GeneCards custom track
MIR6758 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6758 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6758 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6758 Gene

Proteins for MIR6758 Gene

Post-translational modifications for MIR6758 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6758 Gene

Domains & Families for MIR6758 Gene

Gene Families for MIR6758 Gene

HGNC:
genes like me logo Genes that share domains with MIR6758: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6758 Gene

Function for MIR6758 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6758 Gene

Localization for MIR6758 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6758 Gene

Pathways & Interactions for MIR6758 Gene

genes like me logo Genes that share pathways with MIR6758: view

Gene Ontology (GO) - Biological Process for MIR6758 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6758 Gene

Drugs & Compounds for MIR6758 Gene

No Compound Related Data Available

Transcripts for MIR6758 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6758 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075A7D5_9606 precursor_RNA 63 3

RefSeq: NR_106816,

Ensembl: ENST00000620653 (view in UCSC) ,

miRBase: MI0022603,

URS000075A3BC_9606 miRNA 23 2

RefSeq: NR_106816,

miRBase: MIMAT0027416,

URS000075B07E_9606 miRNA 20 2

RefSeq: NR_106816,

miRBase: MIMAT0027417,

MIR6758 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6758 Gene

No ASD Table

Relevant External Links for MIR6758 Gene

GeneLoc Exon Structure for
MIR6758

No data available for mRNA/cDNA for MIR6758 Gene

Expression for MIR6758 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6758 Gene

Orthologs for MIR6758 Gene

Evolution for MIR6758 Gene

ENSEMBL:
Gene Tree for MIR6758 (if available)
TreeFam:
Gene Tree for MIR6758 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR6758

No data available for Orthologs for MIR6758 Gene

Paralogs for MIR6758 Gene

No data available for Paralogs for MIR6758 Gene

Variants for MIR6758 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6758 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1594833474 Uncertain Significance: Interstitial lung and liver disease; Charcot-Marie-Tooth disease, axonal, type 2u 57,512,750(+) G/C
NM_004990.4(MARS1):c.1754-1G>C
SPLICE_ACCEPTOR_VARIANT,NON_CODING_TRANSCRIPT
rs377361080 Likely Benign: Interstitial lung and liver disease; Charcot-Marie-Tooth disease, axonal, type 2u; not specified 57,512,747(+) C/A
NM_004990.4(MARS1):c.1754-4C>A
NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6758 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6758 Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv2759901 CNV gain 17122850
esv3419248 CNV duplication 20981092
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781

Additional Variant Information for MIR6758 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6758
Leiden Open Variation Database (LOVD)
MIR6758

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6758 Gene

Disorders for MIR6758 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR6758 Gene - From: GCD

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2u
  • cmt2u
interstitial lung and liver disease
  • illd
charcot-marie-tooth disease
  • cmt - charcot-marie-tooth disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR6758

genes like me logo Genes that share disorders with MIR6758: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR6758 Gene

Publications for MIR6758 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6758 Gene

Sources for MIR6758 Gene