microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6753 Gene

Data sources for MIR6753 Gene:

RNA type for MIR6753 Gene

miRNA

Aliases for MIR6753 Gene

External Ids for MIR6753 Gene

Previous GeneCards Identifiers for MIR6753 Gene

  • GC11U902127

Summaries for MIR6753 Gene

Entrez Gene Summary for MIR6753 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6753 Gene

MIR6753 (MicroRNA 6753) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6753 Gene

Genomics for MIR6753 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6753 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J068045 Enhancer 0.4 dbSUPER 250.7 +1.7 1651 1.3 ZNF548 ZFP36 ZMYM3 ZNF121 HSALNG0085212 MIR6753 PPP6R3 ENSG00000255031 ENSG00000260808 MRGPRF-AS1 MRGPRF KDM2A KMT5B ENSG00000261625
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6753 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6753 Gene

Latest Assembly
chr11:68,044,794-68,044,957
(GRCh38/hg38)
Size:
164 bases
Orientation:
Plus strand

Previous Assembly
chr11:67,812,261-67,812,424
(GRCh37/hg19 by Entrez Gene)
Size:
164 bases
Orientation:
Plus strand

Genomic View for MIR6753 Gene

Genes around MIR6753 on UCSC Golden Path with GeneCards custom track
MIR6753 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6753 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6753 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6753 Gene

Proteins for MIR6753 Gene

Post-translational modifications for MIR6753 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6753 Gene

Domains & Families for MIR6753 Gene

Gene Families for MIR6753 Gene

HGNC:
genes like me logo Genes that share domains with MIR6753: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6753 Gene

Function for MIR6753 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6753 Gene

Localization for MIR6753 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6753 Gene

Pathways & Interactions for MIR6753 Gene

PathCards logo

SuperPathways for MIR6753 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6753 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6753 Gene

Drugs & Compounds for MIR6753 Gene

No Compound Related Data Available

Transcripts for MIR6753 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6753 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075CB3A_9606 precursor_RNA 164 3

RefSeq: NR_106811,

Ensembl: ENST00000617169 (view in UCSC) ,

miRBase: MI0022598,

URS000075A4C6_9606 miRNA 22 2

RefSeq: NR_106811,

miRBase: MIMAT0027407,

URS000075EF1E_9606 miRNA 22 2

RefSeq: NR_106811,

miRBase: MIMAT0027406,

MIR6753 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6753 Gene

No ASD Table

Relevant External Links for MIR6753 Gene

GeneLoc Exon Structure for
MIR6753

No data available for mRNA/cDNA for MIR6753 Gene

Expression for MIR6753 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6753 Gene

Orthologs for MIR6753 Gene

Evolution for MIR6753 Gene

ENSEMBL:
Gene Tree for MIR6753 (if available)
TreeFam:
Gene Tree for MIR6753 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR6753

No data available for Orthologs for MIR6753 Gene

Paralogs for MIR6753 Gene

No data available for Paralogs for MIR6753 Gene

Variants for MIR6753 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6753 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6753 Gene

Variant ID Type Subtype PubMed ID
dgv1221n100 CNV gain 25217958
dgv1981n54 CNV gain 21841781
dgv1983n54 CNV loss 21841781
dgv1984n54 CNV loss 21841781
esv2759835 CNV gain+loss 17122850
nsv468606 CNV gain 19166990
nsv468615 CNV loss 19166990
nsv469856 CNV gain 16826518
nsv469964 CNV loss 18288195
nsv555278 CNV loss 21841781
nsv555282 CNV loss 21841781
nsv825963 CNV gain 20364138
nsv8836 CNV gain 18304495
nsv951026 CNV deletion 24416366

Additional Variant Information for MIR6753 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6753
Leiden Open Variation Database (LOVD)
MIR6753

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6753 Gene

Disorders for MIR6753 Gene

Additional Disease Information for MIR6753

No disorders were found for MIR6753 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6753 Gene

Publications for MIR6753 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6753 Gene

Sources for MIR6753 Gene