microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6751 Gene

Data sources for MIR6751 Gene:

Subcategory (RNA class) for MIR6751 Gene

miRNA

Aliases for MIR6751 Gene

External Ids for MIR6751 Gene

Previous GeneCards Identifiers for MIR6751 Gene

  • GC11U902126

Summaries for MIR6751 Gene

Entrez Gene Summary for MIR6751 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6751 Gene

MIR6751 (MicroRNA 6751) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and HIV Life Cycle.

Additional gene information for MIR6751 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6751 Gene

Genomics for MIR6751 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6751 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065129 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -3.3 -3295 7.2 CHD2 TBP ZBTB10 SP1 MXD4 SIX5 NR2C1 MNT IKZF1 BRCA1 SYVN1 lnc-FAU-1 lnc-MRPL49-1 piR-49970 SPDYC PCNX3 SF1 POLA2 EIF1AD ZFPL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6751 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6751 Gene

Latest Assembly
chr11:65,129,916-65,129,978
(GRCh38/hg38)
Size:
63 bases
Orientation:
Minus strand

Previous Assembly
chr11:64,897,388-64,897,450
(GRCh37/hg19 by Entrez Gene)
Size:
63 bases
Orientation:
Minus strand

Genomic View for MIR6751 Gene

Genes around MIR6751 on UCSC Golden Path with GeneCards custom track
MIR6751 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6751 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6751 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6751 Gene

Proteins for MIR6751 Gene

Post-translational modifications for MIR6751 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6751 Gene

Domains & Families for MIR6751 Gene

Gene Families for MIR6751 Gene

HGNC:
genes like me logo Genes that share domains with MIR6751: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6751 Gene

Function for MIR6751 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6751 Gene

Localization for MIR6751 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6751 Gene

Pathways & Interactions for MIR6751 Gene

genes like me logo Genes that share pathways with MIR6751: view

Gene Ontology (GO) - Biological Process for MIR6751 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6751 Gene

Drugs & Compounds for MIR6751 Gene

No Compound Related Data Available

Transcripts for MIR6751 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6751 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B59D_9606 precursor_RNA 63 3

RefSeq: NR_106809,

Ensembl: ENST00000610479 (view in UCSC) ,

miRBase: MI0022596,

URS000075A393_9606 miRNA 23 2

RefSeq: NR_106809,

miRBase: MIMAT0027402,

URS000075EDBE_9606 miRNA 21 2

RefSeq: NR_106809,

miRBase: MIMAT0027403,

MIR6751 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6751 Gene

No ASD Table

Relevant External Links for MIR6751 Gene

GeneLoc Exon Structure for
MIR6751

No data available for mRNA/cDNA for MIR6751 Gene

Expression for MIR6751 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6751 Gene

Orthologs for MIR6751 Gene

Evolution for MIR6751 Gene

ENSEMBL:
Gene Tree for MIR6751 (if available)
TreeFam:
Gene Tree for MIR6751 (if available)

No data available for Orthologs for MIR6751 Gene

Paralogs for MIR6751 Gene

No data available for Paralogs for MIR6751 Gene

Variants for MIR6751 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6751 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6751 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Additional Variant Information for MIR6751 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6751

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6751 Gene

Disorders for MIR6751 Gene

Additional Disease Information for MIR6751

No disorders were found for MIR6751 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6751 Gene

Publications for MIR6751 Gene

  1. Triptolide antagonized the cisplatin resistance in human ovarian cancer cell line A2780/CP70 via hsa-mir-6751. (PMID: 29966441) Wang R … Liu Y (Future medicinal chemistry 2018) 3
  2. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6751 Gene

Sources for MIR6751 Gene