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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR6748 Gene
Data sources for MIR6748 Gene:
Subcategory (RNA class) for MIR6748 Gene
miRNA
Aliases for MIR6748 Gene
- MicroRNA 6748 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-Mir-6748 (HGNC, NCBI Entrez Gene)
- MicroRNA Mir-6748 (NCBI Entrez Gene)
- MIMAT0027397 (miRBase)
- MIMAT0027396 (miRBase)
- MI0022593 (miRBase)
- MIR6748 (Ensembl)
External Ids for MIR6748 Gene
- HGNC: 50141
- NCBI Entrez Gene: 102465448
- Ensembl: ENSG00000284535
Previous GeneCards Identifiers for MIR6748 Gene
- GC11U902228
Summaries for MIR6748 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR6748 Gene
MIR6748 (MicroRNA 6748) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Innate Immune System.
Additional gene information for MIR6748 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6748 Gene
Genomics for MIR6748 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR6748 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J062785 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | -1.9 | -1914 | 4.2 | CHD2 TBP SP1 MXD4 NR2C1 MNT DEK SMAD5 ETS1 IRF2 | TMEM179B ENSG00000269176 HSALNG0084658 NONHSAG008544.2 MIR6748 TTC9C SNHG1 CSKMT TMEM223 WDR74 | |
| GH11J062790 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +1.8 | 1835 | 2.9 | TBP MXD4 SMAD5 ETS1 MBD2 ZNF217 POLR2A ELF1 THAP11 ARNT | TMEM223 MN297054 MIR6514 MIR6748 lnc-TMEM223-1 piR-55414 BSCL2 SNHG1 NXF1 CSKMT |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR6748 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR6748 Gene
Latest Assembly
- chr11:62,789,815-62,789,885
- (GRCh38/hg38)
- Size:
- 71 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:62,557,287-62,557,357
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 71 bases
- Orientation:
- Plus strand
Genomic View for MIR6748 Gene
Genes around MIR6748 on UCSC Golden Path with GeneCards custom track
MIR6748 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q12.3 by HGNC
- 11q12.3 by Entrez Gene
- 11q12.3 by Ensembl
MIR6748 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR6748 Gene
Proteins for MIR6748 Gene
Post-translational modifications for MIR6748 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR6748 Gene
Domains & Families for MIR6748 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6748 Gene
Function for MIR6748 Gene
CRISPR products for research
Inhibitory RNAs for research
Clone products for research
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6748 Gene
Localization for MIR6748 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6748 Gene
Pathways & Interactions for MIR6748 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for MIR6748 Gene
3 Reactome pathways for MIR6748 Gene
No data available for Interacting Proteins and SIGNOR curated interactions for MIR6748 Gene
Transcripts for MIR6748 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6748 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075D023_9606 | pre_miRNA | 71 | 3 |
RefSeq: NR_106806, Ensembl: ENST00000610433 (view in UCSC) , miRBase: MI0022593, |
| URS000075ECB7_9606 | miRNA | 22 | 2 |
RefSeq: NR_106806, miRBase: MIMAT0027396, |
| URS000075E2F1_9606 | miRNA | 21 | 2 |
RefSeq: NR_106806, miRBase: MIMAT0027397, |
MIR6748 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
CRISPR products for research
Inhibitory RNAs for research
Clone products for research
Relevant External Links for MIR6748 Gene
- GeneLoc Exon Structure for
- MIR6748
No data available for mRNA/cDNA for MIR6748 Gene
Expression for MIR6748 Gene
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR6748
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6748 Gene
Orthologs for MIR6748 Gene
No data available for Orthologs for MIR6748 Gene
Paralogs for MIR6748 Gene
No data available for Paralogs for MIR6748 Gene
Variants for MIR6748 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR6748 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR6748
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6748 Gene
Disorders for MIR6748 Gene
Additional Disease Information for MIR6748
No disorders were found for MIR6748 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6748 Gene
Publications for MIR6748 Gene
- Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
ExternalLinks
Products for MIR6748 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR6748
- Origene Custom Protein Services for MIR6748
- Browse OriGene Inhibitory RNA Products For MIR6748
- OriGene qPCR primer pairs for MIR6748
- Browse CRISPR knockouts for MIR6748
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR6748
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR6748
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR6748
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR6748
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR6748
Sources for MIR6748 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB