microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6746 Gene

Subcategory (RNA class) for MIR6746 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR6746 Gene

  • MicroRNA 6746 2 3 5
  • MicroRNA Mir-6746 3
  • Hsa-Mir-6746 3
  • MIMAT0027392 53
  • MIMAT0027393 53
  • MI0022591 53
  • MIR6746 2

External Ids for MIR6746 Gene

Previous GeneCards Identifiers for MIR6746 Gene

  • GC11U902174

Summaries for MIR6746 Gene

Entrez Gene Summary for MIR6746 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6746 Gene

MIR6746 (MicroRNA 6746) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6746 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6746 Gene

Genomics for MIR6746 Gene

GeneHancer (GH) Regulatory Elements for MIR6746 Gene

Promoters and enhancers for MIR6746 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J061878 Enhancer 0.4 Ensembl dbSUPER 750.6 +0.2 177 0.2 NR2C1 MIR6746 FADS3 RF00017-931
GH11J061879 Enhancer 0.3 Ensembl dbSUPER 750.6 -1.1 -1123 0.4 MIR6746 lnc-RAB3IL1-3 FADS3
GH11J061869 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.4 +7.6 7571 2.4 CTCF SMARCE1 RUNX1 MYC CC2D1A L3MBTL2 MAX DACH1 RAD21 TEAD4 FADS2 TMEM179B ENSG00000267811 ENSG00000269176 TMEM132A EEF1G FEN1 RF00017-931 MIR6746
GH11J061873 Enhancer 0.7 Ensembl ENCODE dbSUPER 0.6 +3.7 3657 1.6 MAX RAD21 SMC3 FADS2 MIR6746 RF00017-931 FADS3
GH11J061866 Enhancer 0.6 Ensembl 0.4 +11.8 11777 0.6 POLR2A NFE2 SCRT2 MGA SCRT1 HDGF GATAD2A ZNF687 ZNF592 VEZF1 EEF1G RF00017-931 MIR6746 FADS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6746 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6746 Gene

Genomic Locations for MIR6746 Gene
chr11:61,878,216-61,878,278
(GRCh38/hg38)
Size:
63 bases
Orientation:
Minus strand

Genomic View for MIR6746 Gene

Genes around MIR6746 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6746 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6746 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6746 Gene

Proteins for MIR6746 Gene

Post-translational modifications for MIR6746 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6746 Gene

Domains & Families for MIR6746 Gene

Gene Families for MIR6746 Gene

HGNC:
genes like me logo Genes that share domains with MIR6746: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6746 Gene

Function for MIR6746 Gene

Phenotypes From GWAS Catalog for MIR6746 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6746 Gene

Localization for MIR6746 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6746 Gene

Pathways & Interactions for MIR6746 Gene

PathCards logo

SuperPathways for MIR6746 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6746 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR6746 Gene

Drugs & Compounds for MIR6746 Gene

No Compound Related Data Available

Transcripts for MIR6746 Gene

mRNA/cDNA for MIR6746 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6746 Gene

No ASD Table

Relevant External Links for MIR6746 Gene

GeneLoc Exon Structure for
MIR6746
ECgene alternative splicing isoforms for
MIR6746

Expression for MIR6746 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6746 Gene:

MIR6746
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6746 Gene

Orthologs for MIR6746 Gene

Evolution for MIR6746 Gene

ENSEMBL:
Gene Tree for MIR6746 (if available)
TreeFam:
Gene Tree for MIR6746 (if available)

No data available for Orthologs for MIR6746 Gene

Paralogs for MIR6746 Gene

No data available for Paralogs for MIR6746 Gene

Variants for MIR6746 Gene

Sequence variations from dbSNP and Humsavar for MIR6746 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001265639 -- 61,878,096(-) A/C downstream_transcript_variant
rs1004763703 -- 61,877,962(-) G/A downstream_transcript_variant
rs1006165786 -- 61,880,271(-) G/A upstream_transcript_variant
rs1007624620 -- 61,880,123(-) A/G upstream_transcript_variant
rs1008260830 -- 61,880,237(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6746 Gene

Variant ID Type Subtype PubMed ID
nsv468585 CNV loss 19166990
nsv528697 CNV loss 19592680
nsv555171 CNV loss 21841781

Additional Variant Information for MIR6746 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6746

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6746 Gene

Disorders for MIR6746 Gene

Additional Disease Information for MIR6746

No disorders were found for MIR6746 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6746 Gene

Publications for MIR6746 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR6746 Gene

Sources for MIR6746 Gene