Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6745 (MicroRNA 6745) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J047175 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +2.0 | 1997 | 4.7 | SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 NFKBIZ NFRKB POLR2A | ARFGAP2 MIR6745 lnc-PACSIN3-1 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 DDB2 ENSG00000244313 AMBRA1 | |
GH11J047181 | Enhancer | 0.5 | Ensembl dbSUPER | 600.7 | -1.9 | -1864 | 1.2 | BCOR ZMYM3 | MIR6745 PACSIN3 LRP4 ENSG00000271350 ARFGAP2 | |
GH11J047182 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | -6.6 | -6631 | 8.2 | HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 NFKBIZ KDM1A | PACSIN3 JX952203 FNBP4 NUP160 ENSG00000271350 ENSG00000200090 AMBRA1 ENSG00000270060 CELF1 LRP4 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C2C8_9606 | precursor_RNA | 127 | 4 |
HGNC: 50106, RefSeq: NR_106803, Ensembl: ENST00000612694 (view in UCSC) , miRBase: MI0022590, |
URS000075AE63_9606 | miRNA | 21 | 2 |
RefSeq: NR_106803, miRBase: MIMAT0027391, |
No disorders were found for MIR6745 Gene.