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Aliases for MIR6734 Gene

Subcategory (RNA class) for MIR6734 Gene

miRNA

Quality Score for this RNA gene is

18

Aliases for MIR6734 Gene

  • MicroRNA 6734 2 3 5
  • MicroRNA Mir-6734 3
  • Hsa-Mir-6734 3

External Ids for MIR6734 Gene

Previous GeneCards Identifiers for MIR6734 Gene

  • GC01U904090

Summaries for MIR6734 Gene

Entrez Gene Summary for MIR6734 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6734 Gene

MIR6734 (MicroRNA 6734) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are alpha-linolenic acid (ALA) metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Additional gene information for MIR6734 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR6734 Gene

Genomics for MIR6734 Gene

GeneHancer (GH) Regulatory Elements for MIR6734 Gene

Promoters and enhancers for MIR6734 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043362 Enhancer 0.7 Ensembl dbSUPER 600.7 +1.3 1314 0.8 POLR2A SUPT5H JUND ZBTB33 MIR6734 GC01P043360 ELOVL1 CDC20
GH01J043365 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.7 -2.8 -2838 4.9 ZNF652 SP1 ZFX CC2D1A ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A ELOVL1 MED8 MPL SZT2 HYI MIR6734
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6734 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6734 Gene

Genomic Locations for MIR6734 Gene
chr1:43,364,648-43,364,715
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR6734 Gene

Genes around MIR6734 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6734 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6734 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6734 Gene

ORGUL Member Location for MIR6734 Gene

ORGUL Member Location for MIR6734 gene

Proteins for MIR6734 Gene

Post-translational modifications for MIR6734 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6734 Gene

Domains & Families for MIR6734 Gene

Gene Families for MIR6734 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR6734: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR6734 Gene

Function for MIR6734 Gene

Phenotypes From GWAS Catalog for MIR6734 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6734 Gene

Localization for MIR6734 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6734 Gene

Drugs & Compounds for MIR6734 Gene

No Compound Related Data Available

Transcripts for MIR6734 Gene

mRNA/cDNA for MIR6734 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6734 Gene

No ASD Table

Relevant External Links for MIR6734 Gene

GeneLoc Exon Structure for
MIR6734
ECgene alternative splicing isoforms for
MIR6734

Expression for MIR6734 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6734 Gene:

MIR6734
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6734 Gene

Orthologs for MIR6734 Gene

Evolution for MIR6734 Gene

ENSEMBL:
Gene Tree for MIR6734 (if available)
TreeFam:
Gene Tree for MIR6734 (if available)

No data available for Orthologs for MIR6734 Gene

Paralogs for MIR6734 Gene

No data available for Paralogs for MIR6734 Gene

Variants for MIR6734 Gene

Sequence variations from dbSNP and Humsavar for MIR6734 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1002036851 -- 43,364,928(-) C/T upstream_transcript_variant
rs1003007566 -- 43,366,343(-) G/A upstream_transcript_variant
rs1004189336 -- 43,364,823(-) C/A upstream_transcript_variant
rs1006719024 -- 43,364,725(-) T/A upstream_transcript_variant
rs1006879848 -- 43,365,502(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6734 Gene

Variant ID Type Subtype PubMed ID
nsv546128 CNV loss 21841781

Additional Variant Information for MIR6734 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6734

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6734 Gene

Disorders for MIR6734 Gene

Additional Disease Information for MIR6734

No disorders were found for MIR6734 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6734 Gene

Publications for MIR6734 Gene

  1. miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. (PMID: 27509128) Kang MR … Kang JS (PloS one 2016) 3 58
  2. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR6734 Gene

Sources for MIR6734 Gene

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