microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6734 Gene

Subcategory (RNA class) for MIR6734 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR6734 Gene

  • MicroRNA 6734 2 3 5
  • Hsa-Mir-6734 2 3
  • MIR6734 2 5
  • MicroRNA Mir-6734 3
  • Hsa-MiR-6734-5p 163
  • MIMAT0027370 50
  • MIMAT0027369 50
  • MI0022579 50

External Ids for MIR6734 Gene

Previous GeneCards Identifiers for MIR6734 Gene

  • GC01U904090

Summaries for MIR6734 Gene

Entrez Gene Summary for MIR6734 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6734 Gene

MIR6734 (MicroRNA 6734) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Metabolism.

Additional gene information for MIR6734 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6734 Gene

Genomics for MIR6734 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6734 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043364 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 +0.1 114 0.4 POLR2A NR2F6 NR2C1 MIR6734 ELOVL1 lnc-MED8-1 CDC20
GH01J043362 Enhancer 0.6 dbSUPER 600.7 +1.1 1121 1.6 POLR2A RBFOX2 RBM22 NFIC NR2F1 HIC1 JUND NR2F6 SUPT5H CEBPB MIR6734 CDC20 ELOVL1
GH01J043365 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.7 -2738 4.7 HNRNPL GATAD2A REST PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ KDM1A ELOVL1 MED8-AS1 lnc-CDC20-2 lnc-MED8-1 MED8 SZT2 MPL HYI MIR6734 CDC20
GH01J043357 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +5.1 5069 4.1 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 CTCF PRDM10 IKZF1 POLR2A ZNF692 CDC20 ENSG00000234694 LOC105378687 MED8 SZT2 PPIH P3H1 HYI KDM4A-AS1 ELOVL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6734 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6734 Gene

Genomic Locations for MIR6734 Gene
chr1:43,364,648-43,364,715
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR6734 Gene

Genes around MIR6734 on UCSC Golden Path with GeneCards custom track
MIR6734 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6734 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6734 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6734 Gene

Proteins for MIR6734 Gene

Post-translational modifications for MIR6734 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6734 Gene

Domains & Families for MIR6734 Gene

Gene Families for MIR6734 Gene

HGNC:
genes like me logo Genes that share domains with MIR6734: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6734 Gene

Function for MIR6734 Gene

Phenotypes From GWAS Catalog for MIR6734 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6734 Gene

Localization for MIR6734 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6734 Gene

Pathways & Interactions for MIR6734 Gene

genes like me logo Genes that share pathways with MIR6734: view

Gene Ontology (GO) - Biological Process for MIR6734 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6734 Gene

Drugs & Compounds for MIR6734 Gene

No Compound Related Data Available

Transcripts for MIR6734 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6734 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C67C_9606 precursor_RNA 68 4

HGNC: 50219,

RefSeq: NR_106792,

Ensembl: ENST00000621166 (view in UCSC) ,

miRBase: MI0022579,

URS000075E8C3_9606 miRNA 23 3

RefSeq: NR_106792,

LncBase: hsa-miR-6734-5p,

miRBase: MIMAT0027369,

URS000075EB5C_9606 miRNA 23 2

RefSeq: NR_106792,

miRBase: MIMAT0027370,

MIR6734 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6734 Gene

No ASD Table

Relevant External Links for MIR6734 Gene

GeneLoc Exon Structure for
MIR6734

No data available for mRNA/cDNA for MIR6734 Gene

Expression for MIR6734 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6734 Gene

Orthologs for MIR6734 Gene

Evolution for MIR6734 Gene

ENSEMBL:
Gene Tree for MIR6734 (if available)
TreeFam:
Gene Tree for MIR6734 (if available)

No data available for Orthologs for MIR6734 Gene

Paralogs for MIR6734 Gene

No data available for Paralogs for MIR6734 Gene

Variants for MIR6734 Gene

Additional dbSNP identifiers (rs#s) for MIR6734 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6734 Gene

Variant ID Type Subtype PubMed ID
nsv546128 CNV loss 21841781

Additional Variant Information for MIR6734 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6734

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6734 Gene

Disorders for MIR6734 Gene

Additional Disease Information for MIR6734

No disorders were found for MIR6734 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6734 Gene

Publications for MIR6734 Gene

  1. miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. (PMID: 27509128) Kang MR … Kang JS (PloS one 2016) 3
  2. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6734 Gene

Sources for MIR6734 Gene