microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6728 Gene

Subcategory (RNA class) for MIR6728 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR6728 Gene

  • MicroRNA 6728 2 3 5
  • MicroRNA Mir-6728 3
  • Hsa-Mir-6728 3
  • MIMAT0027357 53
  • MIMAT0027358 53
  • MI0022573 53
  • MIR6728 2

External Ids for MIR6728 Gene

Previous GeneCards Identifiers for MIR6728 Gene

  • GC01U904146

Summaries for MIR6728 Gene

Entrez Gene Summary for MIR6728 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6728 Gene

MIR6728 (MicroRNA 6728) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6728 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6728 Gene

Genomics for MIR6728 Gene

GeneHancer (GH) Regulatory Elements for MIR6728 Gene

Promoters and enhancers for MIR6728 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J008864 Enhancer 0.9 Ensembl ENCODE dbSUPER 750.6 +0.7 715 2.7 POLR2A HLF SP1 ZBTB33 BACH1 SCRT2 SCRT1 SUPT5H MYNN ZGPAT MIR6728 ENO1 piR-32214-007
GH01J008867 Enhancer 0.6 dbSUPER 750.6 -1.6 -1551 1.2 POLR2A ZNF121 HNRNPUL1 SOX13 PRDM4 CREM SUPT5H MYNN ZNF511 NUFIP1 MIR6728 RERE-AS1 ENO1 lnc-RERE-6
GH01J008869 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -9.2 -9200 11.8 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF SREBF1 ZBTB6 FOXA1 SMARCE1 ENO1 RERE-AS1 RERE GPR157 SPSB1 CLSTN1 PIK3CD-AS2 MIR34AHG SLC45A1 H6PD
GH01J008856 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 +7.5 7505 5.4 ZBTB40 CTCF RBPJ SMARCE1 POLR2A NR2F6 MIXL1 RUNX1 HLF RBM39 piR-32214-007 ENO1 RERE-AS1 RNU6-304P RERE MIR6728
GH01J008870 Enhancer 0.8 ENCODE dbSUPER 0.6 -2.7 -2667 0.2 POLR2A ZNF652 SP7 ZNF384 SCRT2 ZNF205 NFIC SUPT5H MYNN ZNF511 MIR6728 ENO1 lnc-RERE-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6728 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6728 Gene

Genomic Locations for MIR6728 Gene
chr1:8,866,502-8,866,590
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR6728 Gene

Genes around MIR6728 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6728 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6728 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6728 Gene

Proteins for MIR6728 Gene

Post-translational modifications for MIR6728 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6728 Gene

Domains & Families for MIR6728 Gene

Gene Families for MIR6728 Gene

HGNC:
genes like me logo Genes that share domains with MIR6728: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6728 Gene

Function for MIR6728 Gene

Phenotypes From GWAS Catalog for MIR6728 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6728 Gene

Localization for MIR6728 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6728 Gene

Pathways & Interactions for MIR6728 Gene

PathCards logo

SuperPathways for MIR6728 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6728 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR6728 Gene

Drugs & Compounds for MIR6728 Gene

No Compound Related Data Available

Transcripts for MIR6728 Gene

mRNA/cDNA for MIR6728 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6728 Gene

No ASD Table

Relevant External Links for MIR6728 Gene

GeneLoc Exon Structure for
MIR6728
ECgene alternative splicing isoforms for
MIR6728

Expression for MIR6728 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6728 Gene:

MIR6728
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6728 Gene

Orthologs for MIR6728 Gene

Evolution for MIR6728 Gene

ENSEMBL:
Gene Tree for MIR6728 (if available)
TreeFam:
Gene Tree for MIR6728 (if available)

No data available for Orthologs for MIR6728 Gene

Paralogs for MIR6728 Gene

No data available for Paralogs for MIR6728 Gene

Variants for MIR6728 Gene

Sequence variations from dbSNP and Humsavar for MIR6728 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000800309 -- 8,867,742(-) G/A upstream_transcript_variant
rs1001859718 -- 8,867,118(-) G/A upstream_transcript_variant
rs1003355179 -- 8,867,317(-) T/G upstream_transcript_variant
rs1003883253 -- 8,867,050(-) C/A upstream_transcript_variant
rs1004942307 -- 8,868,085(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6728 Gene

Variant ID Type Subtype PubMed ID
nsv1001865 CNV gain 25217958
nsv545345 CNV gain 21841781

Additional Variant Information for MIR6728 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6728

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6728 Gene

Disorders for MIR6728 Gene

Additional Disease Information for MIR6728

No disorders were found for MIR6728 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6728 Gene

Publications for MIR6728 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR6728 Gene

Sources for MIR6728 Gene