microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR668 Gene

Subcategory (RNA class) for MIR668 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR668 Gene

  • MicroRNA 668 2 3 5
  • Hsa-Mir-668 2 3
  • MIR668 2 5
  • MIMAT0003881 50
  • MIMAT0026636 50
  • MI0003761 50
  • MIRN668 3
  • RF00890 168

External Ids for MIR668 Gene

Previous HGNC Symbols for MIR668 Gene

  • MIRN668

Previous GeneCards Identifiers for MIR668 Gene

  • GC14P100833
  • GC14P100923
  • GC14P101524
  • GC14P101553
  • GC14P101588
  • GC14P101627
  • GC14P101655
  • GC14P101689
  • GC14P101727
  • GC14P101767
  • GC14P101825
  • GC14P101965
  • GC14P102162
  • GC14P101265
  • GC14P101789
  • GC14P103645
  • GC14P103865
  • GC14P104141
  • GC14P104483
  • GC14P102077
  • GC14P102366
  • GC14P102536
  • GC14P102715
  • GC14P102888
  • GC14P103061
  • GC14P103258
  • GC14P103462

Summaries for MIR668 Gene

Entrez Gene Summary for MIR668 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR668 Gene

MIR668 (MicroRNA 668) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR668 Gene

Additional gene information for MIR668 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR668 Gene

Genomics for MIR668 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR668 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101056 Enhancer 0.3 Ensembl 600.7 +1.2 1243 0.2 FOS CTCF MIR134 MIR323B MIR485 MIR668 MIR154 RTL1 DIO3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR668 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR668 Gene

Genomic Locations for MIR668 Gene
chr14:101,055,258-101,055,323
(GRCh38/hg38)
Size:
66 bases
Orientation:
Plus strand
chr14:101,521,595-101,521,660
(GRCh37/hg19)
Size:
66 bases
Orientation:
Plus strand

Genomic View for MIR668 Gene

Genes around MIR668 on UCSC Golden Path with GeneCards custom track
MIR668 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR668 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR668 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR668 Gene

Proteins for MIR668 Gene

Post-translational modifications for MIR668 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR668 Gene

Domains & Families for MIR668 Gene

Gene Families for MIR668 Gene

HGNC:
genes like me logo Genes that share domains with MIR668: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR668 Gene

Function for MIR668 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR668 Gene

Localization for MIR668 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR668 Gene

Pathways & Interactions for MIR668 Gene

PathCards logo

SuperPathways for MIR668 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR668: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR668 Gene

Drugs & Compounds for MIR668 Gene

No Compound Related Data Available

Transcripts for MIR668 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR668 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006F5B1B_9606 precursor_RNA 66 5

HGNC: 33135,

RefSeq: NR_030408,

Ensembl: ENST00000611970 (view in UCSC) ,

miRBase: MI0003761,

Rfam: RF00890,

URS000075C6C5_9606 miRNA 23 2

RefSeq: NR_030408,

miRBase: MIMAT0003881,

URS000075A144_9606 miRNA 19 2

RefSeq: NR_030408,

miRBase: MIMAT0026636,

MIR668 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR668 Gene

No ASD Table

Relevant External Links for MIR668 Gene

GeneLoc Exon Structure for
MIR668

No data available for mRNA/cDNA for MIR668 Gene

Expression for MIR668 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR668

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR668 Gene

Orthologs for MIR668 Gene

Evolution for MIR668 Gene

ENSEMBL:
Gene Tree for MIR668 (if available)
TreeFam:
Gene Tree for MIR668 (if available)

No data available for Orthologs for MIR668 Gene

Paralogs for MIR668 Gene

No data available for Paralogs for MIR668 Gene

Variants for MIR668 Gene

Additional dbSNP identifiers (rs#s) for MIR668 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR668 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR668 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR668

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR668 Gene

Disorders for MIR668 Gene

Additional Disease Information for MIR668

No disorders were found for MIR668 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR668 Gene

Publications for MIR668 Gene

  1. MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury. (PMID: 30325740) Wei Q … Dong Z (The Journal of clinical investigation 2018) 3
  2. miR-668 enhances the radioresistance of human breast cancer cell by targeting IκBα. (PMID: 28138801) Luo M … Yao H (Breast cancer (Tokyo, Japan) 2017) 3
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E … Cuppen E (Genome research 2006) 3

Products for MIR668 Gene

Sources for MIR668 Gene