Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR665 Gene

Subcategory (RNA class) for MIR665 Gene


Quality Score for this RNA gene is


Aliases for MIR665 Gene

  • MicroRNA 665 2 3 5
  • Hsa-Mir-665 3
  • Mir-665 3
  • MIRN665 3

External Ids for MIR665 Gene

ORGUL Members for MIR665 Gene

Previous HGNC Symbols for MIR665 Gene

  • MIRN665

Previous GeneCards Identifiers for MIR665 Gene

  • GC14P100415
  • GC14P101343
  • GC14P101344
  • GC14P101357
  • GC14P102120
  • GC14P101222
  • GC14P101376
  • GC14P103644
  • GC14P102054
  • GC14P102327
  • GC14P102497
  • GC14P102673
  • GC14P102845
  • GC14P103021
  • GC14P103216
  • GC14P103461

Summaries for MIR665 Gene

Entrez Gene Summary for MIR665 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR665 Gene

MIR665 (MicroRNA 665) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR665 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR665 Gene

Genomics for MIR665 Gene

GeneHancer (GH) Regulatory Elements for MIR665 Gene

Promoters and enhancers for MIR665 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100880 Enhancer 0.2 ENCODE 0.4 +5.8 5808 1 GC14P103898 MIR431 GC14P103904 MIR433 MIR665 RTL1 ENSG00000258399
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR665 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR665 Gene

Genomic Locations for MIR665 Gene
72 bases
Plus strand
72 bases
Plus strand

Genomic View for MIR665 Gene

Genes around MIR665 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR665 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR665 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR665 Gene

Proteins for MIR665 Gene

Post-translational modifications for MIR665 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR665 Gene

Domains & Families for MIR665 Gene

Gene Families for MIR665 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR665: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR665 Gene

Function for MIR665 Gene

Gene Ontology (GO) - Molecular Function for MIR665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 30545407
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 29118903
genes like me logo Genes that share ontologies with MIR665: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR665 Gene

Localization for MIR665 Gene

Gene Ontology (GO) - Cellular Components for MIR665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR665: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR665 Gene

Pathways & Interactions for MIR665 Gene

PathCards logo

SuperPathways for MIR665 Gene

No Data Available

Interacting Proteins for MIR665 Gene

Gene Ontology (GO) - Biological Process for MIR665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031047 gene silencing by RNA IDA 30545407
GO:0035195 gene silencing by miRNA IEA --
GO:0045668 negative regulation of osteoblast differentiation IMP 30545407
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 29118903
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IDA 29118903
genes like me logo Genes that share ontologies with MIR665: view

No data available for Pathways by source and SIGNOR curated interactions for MIR665 Gene

Drugs & Compounds for MIR665 Gene

No Compound Related Data Available

Transcripts for MIR665 Gene

mRNA/cDNA for MIR665 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR665 Gene

No ASD Table

Relevant External Links for MIR665 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR665 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR665 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR665 Gene

Orthologs for MIR665 Gene

Evolution for MIR665 Gene

Gene Tree for MIR665 (if available)
Gene Tree for MIR665 (if available)

No data available for Orthologs for MIR665 Gene

Paralogs for MIR665 Gene

No data available for Paralogs for MIR665 Gene

Variants for MIR665 Gene

Sequence variations from dbSNP and Humsavar for MIR665 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000819601 -- 100,875,591(+) G/A downstream_transcript_variant
rs1001470689 -- 100,874,321(+) A/G upstream_transcript_variant
rs1001918225 -- 100,875,380(+) A/C downstream_transcript_variant
rs1003087952 -- 100,875,271(+) G/A/C downstream_transcript_variant
rs1003549805 -- 100,875,448(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR665 Gene

Variant ID Type Subtype PubMed ID
esv1002231 CNV insertion 20482838
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Additional Variant Information for MIR665 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR665 Gene

Disorders for MIR665 Gene

Additional Disease Information for MIR665

No disorders were found for MIR665 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR665 Gene

Publications for MIR665 Gene

  1. MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10. (PMID: 30015865) Liu J … Cheng W (Molecular medicine reports 2018) 3 58
  2. Long non-coding RNA HIF1A-AS2 facilitates adipose-derived stem cells (ASCs) osteogenic differentiation through miR-665/IL6 axis via PI3K/Akt signaling pathway. (PMID: 30545407) Wu R … Wu Q (Stem cell research & therapy 2018) 3 58
  3. DANCR mediated miR-665 regulates proliferation and metastasis of cervical cancer through ERK/SMADs pathway. (PMID: 30582654) Cao L … Dong L (Cancer science 2018) 3 58
  4. Upregulation of miR-665 promotes apoptosis and colitis in inflammatory bowel disease by repressing the endoplasmic reticulum stress components XBP1 and ORMDL3. (PMID: 28333149) Li M … Chen M (Cell death & disease 2017) 3 58
  5. MiR-665 regulates VSMCs proliferation via targeting FGF9 and MEF2D and modulating activities of Wnt/β-catenin signaling. (PMID: 29118903) Li K … Wang L (American journal of translational research 2017) 3 58

Products for MIR665 Gene

Sources for MIR665 Gene

Loading form....