microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR665 Gene

Data sources for MIR665 Gene:

Subcategory (RNA class) for MIR665 Gene

miRNA

Aliases for MIR665 Gene

External Ids for MIR665 Gene

Previous HGNC Symbols for MIR665 Gene

  • MIRN665

Previous GeneCards Identifiers for MIR665 Gene

  • GC14P100415
  • GC14P101343
  • GC14P101344
  • GC14P101357
  • GC14P102120
  • GC14P101222
  • GC14P101376
  • GC14P103644
  • GC14P103864
  • GC14P104140
  • GC14P104482
  • GC14P102054
  • GC14P102327
  • GC14P102497
  • GC14P102673
  • GC14P102845
  • GC14P103021
  • GC14P103216
  • GC14P103461
  • GC14P104827

Summaries for MIR665 Gene

Entrez Gene Summary for MIR665 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR665 Gene

MIR665 (MicroRNA 665) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR665 Gene

Additional gene information for MIR665 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR665 Gene

Genomics for MIR665 Gene

Genomic Locations for MIR665 Gene

Latest Assembly
chr14:100,875,024-100,875,114
(GRCh38/hg38)
Size:
91 bases
Orientation:
Plus strand

Previous Assembly
chr14:101,341,370-101,341,441
(GRCh37/hg19 by Entrez Gene)
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR665 Gene

Genes around MIR665 on UCSC Golden Path with GeneCards custom track
MIR665 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR665 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR665 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR665 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR665 Gene

Proteins for MIR665 Gene

Post-translational modifications for MIR665 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR665 Gene

Domains & Families for MIR665 Gene

Gene Families for MIR665 Gene

HGNC:
genes like me logo Genes that share domains with MIR665: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR665 Gene

Function for MIR665 Gene

Gene Ontology (GO) - Molecular Function for MIR665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 30545407
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 29118903
genes like me logo Genes that share ontologies with MIR665: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR665 Gene

Localization for MIR665 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR665 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR665 Gene

Pathways & Interactions for MIR665 Gene

PathCards logo

SuperPathways for MIR665 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031047 gene silencing by RNA IDA 30545407
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045668 negative regulation of osteoblast differentiation IMP 30545407
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 29118903
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IDA 29118903
genes like me logo Genes that share ontologies with MIR665: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR665 Gene

Drugs & Compounds for MIR665 Gene

No Compound Related Data Available

Transcripts for MIR665 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR665 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000355E82_9606 miRNA 20 5

RefSeq: NR_030617,

LncBase: hsa-miR-665,

miRBase: MIMAT0004952,

TarBase: hsa-miR-665,

ENA: LM380514.1:1..20:ncRNA, LM609968.1:43..62:ncRNA,

URS000075CD82_9606 precursor_RNA 72 4

RefSeq: NR_030617,

Ensembl: ENST00000635949 (view in UCSC) ,

miRBase: MI0005563,

ENA: LM609968.1:1..72:precursor_RNA,

URS00006E94B0_9606 precursor_RNA 91 1

Rfam: RF00921,

URS0001BC110E_9606 pre_miRNA 91 1

Rfam: RF00921,

MIR665 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR665 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR665 Gene

No ASD Table

Relevant External Links for MIR665 Gene

GeneLoc Exon Structure for
MIR665

Expression for MIR665 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR665

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR665 Gene

Orthologs for MIR665 Gene

Evolution for MIR665 Gene

ENSEMBL:
Gene Tree for MIR665 (if available)
TreeFam:
Gene Tree for MIR665 (if available)

No data available for Orthologs for MIR665 Gene

Paralogs for MIR665 Gene

No data available for Paralogs for MIR665 Gene

Variants for MIR665 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR665 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR665 Gene

Variant ID Type Subtype PubMed ID
esv1002231 CNV insertion 20482838
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Additional Variant Information for MIR665 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR665

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR665 Gene

Disorders for MIR665 Gene

Additional Disease Information for MIR665

No disorders were found for MIR665 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR665 Gene

Publications for MIR665 Gene

  1. [MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1]. (PMID: 32222154) Liu R … Cui Y (Zhongguo fei ai za zhi = Chinese journal of lung cancer 2020) 3
  2. microRNA-665 is down-regulated in gastric cancer and inhibits proliferation, invasion, and EMT by targeting PPP2R2A. (PMID: 31923339) Zhang M … Qiao Y (Cell biochemistry and function 2020) 3
  3. DANCR-mediated microRNA-665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway. (PMID: 30582654) Cao L … Dong L (Cancer science 2019) 3
  4. EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia. (PMID: 31465316) Liu NW … Lu Y (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  5. miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer. (PMID: 31209222) Zhao XG … Wang HY (Cell death & disease 2019) 3

Products for MIR665 Gene

Sources for MIR665 Gene