microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR664B Gene

Data sources for MIR664B Gene:

RNA type for MIR664B Gene

miRNA

Aliases for MIR664B Gene

External Ids for MIR664B Gene

Previous HGNC Symbols for MIR664B Gene

  • MIR644B

Previous GeneCards Identifiers for MIR664B Gene

  • GC0XU902007

Summaries for MIR664B Gene

Entrez Gene Summary for MIR664B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR664B Gene

MIR664B (MicroRNA 664b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cell Cycle, Mitotic and Chromosome Maintenance.

Rfam classification for MIR664B Gene

  • Small nucleolar RNA SNORA36 family

Additional gene information for MIR664B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR664B Gene

Genomics for MIR664B Gene

Genomic Locations for MIR664B Gene

Latest Assembly
chrX:154,768,596-154,768,656
(GRCh38/hg38)
Size:
61 bases
Orientation:
Plus strand

Previous Assembly
chrX:153,996,871-153,996,931
(GRCh37/hg19 by Entrez Gene)
Size:
61 bases
Orientation:
Plus strand

Genomic View for MIR664B Gene

Genes around MIR664B on UCSC Golden Path with GeneCards custom track
MIR664B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR664B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR664B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR664B Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR664B Gene

Proteins for MIR664B Gene

Post-translational modifications for MIR664B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR664B Gene

Domains & Families for MIR664B Gene

Gene Families for MIR664B Gene

genes like me logo Genes that share domains with MIR664B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR664B Gene

Function for MIR664B Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR664B Gene

Localization for MIR664B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR664B gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR664B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with MIR664B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR664B Gene

Pathways & Interactions for MIR664B Gene

genes like me logo Genes that share pathways with MIR664B: view

Pathways by source for MIR664B Gene

Gene Ontology (GO) - Biological Process for MIR664B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with MIR664B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR664B Gene

Drugs & Compounds for MIR664B Gene

No Compound Related Data Available

Transcripts for MIR664B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR664B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000057B50A_9606 miRNA 22 5

RefSeq: NR_049842,

LncBase: hsa-miR-664b-3p,

miRBase: MIMAT0022272,

TarBase: hsa-miR-664b-3p,

ENA: LM382958.1:1..22:ncRNA, LM611570.1:40..61:ncRNA,

URS000075DD29_9606 snoRNA 61 4

RefSeq: NR_049842,

Ensembl: ENST00000626756 (view in UCSC) ,

miRBase: MI0019134,

ENA: LM611570.1:1..61:precursor_RNA,

URS000042B108_9606 miRNA 24 4

RefSeq: NR_049842,

miRBase: MIMAT0022271,

TarBase: hsa-miR-664b-5p,

ENA: LM382957.1:1..24:ncRNA, LM611570.1:1..24:ncRNA,

URS0000759BE6_9606 snoRNA 128 2

RefSeq: NR_003705,

snoDB: SNODB1294,

URS0001BBF3F6_9606 snoRNA 130 1

Rfam: RF00340,

MIR664B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR664B Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR664B Gene

No ASD Table

Relevant External Links for MIR664B Gene

GeneLoc Exon Structure for
MIR664B

Expression for MIR664B Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR664B Gene

Orthologs for MIR664B Gene

Evolution for MIR664B Gene

ENSEMBL:
Gene Tree for MIR664B (if available)
TreeFam:
Gene Tree for MIR664B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR664B

No data available for Orthologs for MIR664B Gene

Paralogs for MIR664B Gene

No data available for Paralogs for MIR664B Gene

Variants for MIR664B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR664B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR664B Gene

Variant ID Type Subtype PubMed ID
esv33784 CNV gain+loss 17666407

Additional Variant Information for MIR664B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR664B
Leiden Open Variation Database (LOVD)
MIR664B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR664B Gene

Disorders for MIR664B Gene

Additional Disease Information for MIR664B

No disorders were found for MIR664B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR664B Gene

Publications for MIR664B Gene

  1. MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2. (PMID: 31138473) Li X … Ding Z (Journal of dermatological science 2019) 3
  2. Mir-664 promotes osteosarcoma cells proliferation via downregulating of FOXO4. (PMID: 26463624) Chen B … Chen J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015) 3
  3. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR664B Gene

Sources for MIR664B Gene