microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR664A Gene

Subcategory (RNA class) for MIR664A Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR664A Gene

  • MicroRNA 664a 2 3 5
  • Hsa-MiR-664a-3p 163 173
  • Hsa-MiR-664a-5p 163 173
  • MicroRNA 664 2 3
  • Hsa-Mir-664 2 3
  • MIR664A 2 5
  • Hsa-Mir-664a 3
  • MIMAT0005949 50
  • MIMAT0005948 50
  • MI0006442 50
  • Mir-664a 3
  • MIRN664 3
  • MIR664 3

External Ids for MIR664A Gene

Previous HGNC Symbols for MIR664A Gene

  • MIRN664
  • MIR664

Previous GeneCards Identifiers for MIR664A Gene

  • GC01M220378

Summaries for MIR664A Gene

Entrez Gene Summary for MIR664A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR664A Gene

MIR664A (MicroRNA 664a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR664A include Multiple Sclerosis.

Rfam classification for MIR664A Gene

  • Small nucleolar RNA SNORA36 family

Additional gene information for MIR664A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR664A Gene

Genomics for MIR664A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR664A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J220200 Enhancer 0.3 Ensembl 600.7 +0.4 418 0.4 POLR2A SUPT5H MIR664A SNORA36B RAB3GAP2 EPRS1 lnc-BPNT1-1 lnc-BPNT1-2 IARS2
GH01J220198 Enhancer 0.2 Ensembl 600.7 +1.8 1818 0.8 MIR664A SNORA36B RAB3GAP2 lnc-BPNT1-1 lnc-BPNT1-2 IARS2
GH01J220199 Enhancer 0.2 Ensembl 600.7 +0.9 918 0.2 MIR664A SNORA36B RAB3GAP2 lnc-BPNT1-1 lnc-BPNT1-2 IARS2
GH01J220158 Enhancer 0.3 ENCODE 0.3 +41.1 41065 1.7 CEBPB CEBPG IARS2 MIR194-1 MIR215 EPRS1 RAB3GAP2 lnc-BPNT1-1 MIR664A lnc-BPNT1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR664A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR664A Gene

Genomic Locations for MIR664A Gene
chr1:220,200,538-220,200,619
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand
chr1:220,373,880-220,373,961
(GRCh37/hg19)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR664A Gene

Genes around MIR664A on UCSC Golden Path with GeneCards custom track
MIR664A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR664A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR664A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR664A Gene

Proteins for MIR664A Gene

Post-translational modifications for MIR664A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR664A Gene

Domains & Families for MIR664A Gene

Gene Families for MIR664A Gene

genes like me logo Genes that share domains with MIR664A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR664A Gene

Function for MIR664A Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR664A Gene

Localization for MIR664A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR664A gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR664A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with MIR664A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR664A Gene

Pathways & Interactions for MIR664A Gene

PathCards logo

SuperPathways for MIR664A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR664A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with MIR664A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR664A Gene

Drugs & Compounds for MIR664A Gene

No Compound Related Data Available

Transcripts for MIR664A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR664A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B7FD_9606 precursor_RNA 82 5

HGNC: 35370,

RefSeq: NR_031705,

Ensembl: ENST00000626086 (view in UCSC) ,

miRBase: MI0006442,

ENA: LM610179.1:1..82:precursor_RNA,

URS0000259AE4_9606 miRNA 24 5

RefSeq: NR_031705,

LncBase: hsa-miR-664a-5p,

miRBase: MIMAT0005948,

TarBase: hsa-miR-664a-5p,

ENA: LM380723.1:1..24:ncRNA, LM610179.1:11..34:ncRNA,

URS000029AE45_9606 miRNA 23 5

RefSeq: NR_031705,

LncBase: hsa-miR-664a-3p,

miRBase: MIMAT0005949,

TarBase: hsa-miR-664a-3p,

ENA: LM380724.1:1..23:ncRNA, LM610179.1:49..71:ncRNA,

URS0000563869_9606 miRNA 23 1

ENA: AB372798.1:1..23:ncRNA,

URS00001AEF2D_9606 miRNA 22 1

ENA: AB372799.1:1..22:ncRNA,

MIR664A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR664A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR664A Gene

No ASD Table

Relevant External Links for MIR664A Gene

GeneLoc Exon Structure for
MIR664A

Expression for MIR664A Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR664A Gene

Orthologs for MIR664A Gene

Evolution for MIR664A Gene

ENSEMBL:
Gene Tree for MIR664A (if available)
TreeFam:
Gene Tree for MIR664A (if available)

No data available for Orthologs for MIR664A Gene

Paralogs for MIR664A Gene

No data available for Paralogs for MIR664A Gene

Variants for MIR664A Gene

Additional dbSNP identifiers (rs#s) for MIR664A Gene

Additional Variant Information for MIR664A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR664A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR664A Gene

Disorders for MIR664A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR664A Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
multiple sclerosis
  • multiple sclerosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR664A

genes like me logo Genes that share disorders with MIR664A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR664A Gene

Publications for MIR664A Gene

  1. MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2. (PMID: 31138473) Li X … Ding Z (Journal of dermatological science 2019) 3
  2. MicroRNA-664 Targets Insulin Receptor Substrate 1 to Suppress Cell Proliferation and Invasion in Breast Cancer. (PMID: 29495974) Wu L … Ma D (Oncology research 2019) 3
  3. MicroRNA-664 targets paired box protein 6 to inhibit the oncogenicity of pancreatic ductal adenocarcinoma. (PMID: 30896829) Wang Q … Wang X (International journal of oncology 2019) 3
  4. Overexpression Of hsa-miR-664a-3p Is Associated With Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Via Targeting FHL1. (PMID: 31632001) Zhong S … Wang Y (International journal of chronic obstructive pulmonary disease 2019) 3
  5. miR-664a-3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer. (PMID: 30883979) Wang L … Xu Z (Cell proliferation 2019) 3

Products for MIR664A Gene

Sources for MIR664A Gene