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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR664A (MicroRNA 664a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR664A include Multiple Sclerosis.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J220200 | Enhancer | 0.3 | Ensembl | 600.7 | +0.4 | 418 | 0.4 | POLR2A SUPT5H | MIR664A SNORA36B RAB3GAP2 EPRS1 lnc-BPNT1-1 lnc-BPNT1-2 IARS2 | |
GH01J220198 | Enhancer | 0.2 | Ensembl | 600.7 | +1.8 | 1818 | 0.8 | MIR664A SNORA36B RAB3GAP2 lnc-BPNT1-1 lnc-BPNT1-2 IARS2 | ||
GH01J220199 | Enhancer | 0.2 | Ensembl | 600.7 | +0.9 | 918 | 0.2 | MIR664A SNORA36B RAB3GAP2 lnc-BPNT1-1 lnc-BPNT1-2 IARS2 | ||
GH01J220158 | Enhancer | 0.3 | ENCODE | 0.3 | +41.1 | 41065 | 1.7 | CEBPB CEBPG | IARS2 MIR194-1 MIR215 EPRS1 RAB3GAP2 lnc-BPNT1-1 MIR664A lnc-BPNT1-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0005730 | nucleolus | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075B7FD_9606 | precursor_RNA | 82 | 5 |
HGNC: 35370, RefSeq: NR_031705, Ensembl: ENST00000626086 (view in UCSC) , miRBase: MI0006442, |
URS0000259AE4_9606 | miRNA | 24 | 5 |
RefSeq: NR_031705, LncBase: hsa-miR-664a-5p, miRBase: MIMAT0005948, TarBase: hsa-miR-664a-5p, |
URS000029AE45_9606 | miRNA | 23 | 5 |
RefSeq: NR_031705, LncBase: hsa-miR-664a-3p, miRBase: MIMAT0005949, TarBase: hsa-miR-664a-3p, |
URS0000563869_9606 | miRNA | 23 | 1 |
ENA: AB372798.1:1..23:ncRNA, |
URS00001AEF2D_9606 | miRNA | 22 | 1 |
ENA: AB372799.1:1..22:ncRNA, |
Disorder | Aliases | PubMed IDs |
---|---|---|
multiple sclerosis |
|