microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR659 Gene

Subcategory (RNA class) for MIR659 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR659 Gene

  • MicroRNA 659 2 3 5
  • Hsa-MiR-659-3p 166 177
  • Hsa-MiR-659-5p 177
  • MIMAT0003337 51
  • MIMAT0022710 51
  • Hsa-Mir-659 3
  • MI0003683 51
  • Mir-659 3
  • MIRN659 3
  • MIR659 2

External Ids for MIR659 Gene

Previous HGNC Symbols for MIR659 Gene

  • MIRN659

Previous GeneCards Identifiers for MIR659 Gene

  • GC22M036574
  • GC22M038243
  • GC22M038390
  • GC22M038512
  • GC22M042818
  • GC22M042933
  • GC22M043142
  • GC22M038824
  • GC22M039961
  • GC22M040652
  • GC22M041101
  • GC22M041504
  • GC22M041914
  • GC22M042354
  • GC22M042704

Summaries for MIR659 Gene

Entrez Gene Summary for MIR659 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR659 Gene

MIR659 (MicroRNA 659) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR659 include Frontotemporal Dementia and Dementia.

Additional gene information for MIR659 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR659 Gene

Genomics for MIR659 Gene

GeneHancer (GH) Regulatory Elements for MIR659 Gene

Promoters and enhancers for MIR659 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR659 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR659 Gene

Genomic Locations for MIR659 Gene
chr22:37,847,678-37,847,774
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr22:38,243,685-38,243,781
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR659 Gene

Genes around MIR659 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR659 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR659 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR659 Gene

Proteins for MIR659 Gene

Post-translational modifications for MIR659 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR659 Gene

Domains & Families for MIR659 Gene

Gene Families for MIR659 Gene

HGNC:
genes like me logo Genes that share domains with MIR659: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR659 Gene

Function for MIR659 Gene

Phenotypes From GWAS Catalog for MIR659 Gene

Gene Ontology (GO) - Molecular Function for MIR659 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18723524
genes like me logo Genes that share ontologies with MIR659: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR659 Gene

Localization for MIR659 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR659 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR659 Gene

Pathways & Interactions for MIR659 Gene

PathCards logo

SuperPathways for MIR659 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR659 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IMP 18723524
genes like me logo Genes that share ontologies with MIR659: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR659 Gene

Drugs & Compounds for MIR659 Gene

No Compound Related Data Available

Transcripts for MIR659 Gene

mRNA/cDNA for MIR659 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
4 ENA transcripts :
1 LncBase transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR659 Gene

No ASD Table

Relevant External Links for MIR659 Gene

GeneLoc Exon Structure for
MIR659

Expression for MIR659 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR659 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR659

genes like me logo Genes that share expression patterns with MIR659: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR659 Gene

Orthologs for MIR659 Gene

Evolution for MIR659 Gene

ENSEMBL:
Gene Tree for MIR659 (if available)
TreeFam:
Gene Tree for MIR659 (if available)

No data available for Orthologs for MIR659 Gene

Paralogs for MIR659 Gene

No data available for Paralogs for MIR659 Gene

Variants for MIR659 Gene

Additional dbSNP identifiers (rs#s) for MIR659 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR659 Gene

Variant ID Type Subtype PubMed ID
esv2758838 CNV loss 17122850
esv3893482 CNV gain 25118596

Additional Variant Information for MIR659 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR659

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR659 Gene

Disorders for MIR659 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR659 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
frontotemporal dementia
  • multiple system tauopathy with presenile dementia
dementia
  • dementias
disease of mental health
  • mental health
frontotemporal dementia and/or amyotrophic lateral sclerosis 1
  • ftdals1
digeorge syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR659

genes like me logo Genes that share disorders with MIR659: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR659 Gene

Publications for MIR659 Gene

  1. Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients. (PMID: 25980492) Stigliani S … Corrias MV (Oncotarget 2015) 3 54
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  3. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. (PMID: 18723524) Rademakers R … Dickson DW (Human molecular genetics 2008) 3 54
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54
  5. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 54

Products for MIR659 Gene

Sources for MIR659 Gene