microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR658 Gene

Subcategory (RNA class) for MIR658 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR658 Gene

  • MicroRNA 658 2 3 5
  • Hsa-MiR-658 166 177
  • MIMAT0003336 51
  • Hsa-Mir-658 3
  • MI0003682 51
  • MIRN658 3
  • MIR658 2

External Ids for MIR658 Gene

Previous HGNC Symbols for MIR658 Gene

  • MIRN658

Previous GeneCards Identifiers for MIR658 Gene

  • GC22M036571
  • GC22M038241
  • GC22M038314
  • GC22M039043
  • GC22M039413
  • GC22M040091
  • GC22M038389
  • GC22M038511
  • GC22M042817
  • GC22M042932
  • GC22M043141
  • GC22M038823
  • GC22M039960
  • GC22M040651
  • GC22M041099
  • GC22M041501
  • GC22M041913
  • GC22M042353
  • GC22M042703

Summaries for MIR658 Gene

Entrez Gene Summary for MIR658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR658 Gene

MIR658 (MicroRNA 658) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR658 include Systemic Lupus Erythematosus.

Additional gene information for MIR658 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR658 Gene

Genomics for MIR658 Gene

GeneHancer (GH) Regulatory Elements for MIR658 Gene

Promoters and enhancers for MIR658 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J037841 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.7 723 3.5 ZBTB40 EP300 SIN3A TCF12 POLR2G SP1 NCOR1 GTF2E2 PHF8 FOS ANKRD54 MIR658 GGA1 PLA2G6 lnc-C22orf23-1
GH22J037848 Enhancer 0.2 Ensembl 0.7 -2.9 -2930 0.2 EIF3L MIR659 piR-54438-001 ANKRD54 MIR658 lnc-C22orf23-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR658 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR658 Gene

Genomic Locations for MIR658 Gene
chr22:37,844,272-37,844,371
(GRCh38/hg38)
Size:
100 bases
Orientation:
Minus strand
chr22:38,240,279-38,240,378
(GRCh37/hg19)
Size:
100 bases
Orientation:
Minus strand

Genomic View for MIR658 Gene

Genes around MIR658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR658 Gene

Proteins for MIR658 Gene

Post-translational modifications for MIR658 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR658 Gene

Domains & Families for MIR658 Gene

Gene Families for MIR658 Gene

HGNC:
genes like me logo Genes that share domains with MIR658: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR658 Gene

Function for MIR658 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR658 Gene

Localization for MIR658 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR658 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR658 Gene

Pathways & Interactions for MIR658 Gene

PathCards logo

SuperPathways for MIR658 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR658 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR658 Gene

Drugs & Compounds for MIR658 Gene

No Compound Related Data Available

Transcripts for MIR658 Gene

mRNA/cDNA for MIR658 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR658 Gene

No ASD Table

Relevant External Links for MIR658 Gene

GeneLoc Exon Structure for
MIR658

Expression for MIR658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR658 Gene

genes like me logo Genes that share expression patterns with MIR658: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR658 Gene

Orthologs for MIR658 Gene

Evolution for MIR658 Gene

ENSEMBL:
Gene Tree for MIR658 (if available)
TreeFam:
Gene Tree for MIR658 (if available)

No data available for Orthologs for MIR658 Gene

Paralogs for MIR658 Gene

No data available for Paralogs for MIR658 Gene

Variants for MIR658 Gene

Additional dbSNP identifiers (rs#s) for MIR658 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR658 Gene

Variant ID Type Subtype PubMed ID
esv2666189 CNV deletion 23128226
esv2758838 CNV loss 17122850
esv3647720 CNV loss 21293372
esv3893482 CNV gain 25118596

Additional Variant Information for MIR658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR658 Gene

Disorders for MIR658 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR658 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR658

genes like me logo Genes that share disorders with MIR658: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR658 Gene

Publications for MIR658 Gene

  1. Serum miR-658 induces metastasis of gastric cancer by activating PAX3-MET pathway: A population-based study. (PMID: 29630524) Wu Y … Fang X (Cancer biomarkers : section A of Disease markers 2018) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 54

Products for MIR658 Gene

Sources for MIR658 Gene