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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR658 (MicroRNA 658) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR658 include Systemic Lupus Erythematosus.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH22J037841 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.7 | 723 | 3.5 | BRCA1 ARHGAP35 SP1 CREB1 GATAD2A PRDM10 ZNF629 RFX1 KDM1A ZNF692 | ANKRD54 MIR658 GGA1 PLA2G6 lnc-C22orf23-1 EIF3L GALR3 | |
GH22J037848 | Enhancer | 0.2 | Ensembl | 0.7 | -2.9 | -2930 | 0.2 | EIF3L MIR659 piR-54438-001 ANKRD54 MIR658 lnc-C22orf23-2 GALR3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903561 | extracellular vesicle | HDA | 28798470 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075ABB5_9606 | precursor_RNA | 100 | 4 |
HGNC: 32914, RefSeq: NR_030395, Ensembl: ENST00000385210 (view in UCSC) , miRBase: MI0003682, |
URS00005A1F52_9606 | miRNA | 25 | 4 |
RefSeq: NR_030395, LncBase: hsa-miR-658, miRBase: MIMAT0003336, TarBase: hsa-miR-658, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2666189 | CNV | deletion | 23128226 |
esv2758838 | CNV | loss | 17122850 |
esv3647720 | CNV | loss | 21293372 |
esv3893482 | CNV | gain | 25118596 |
Disorder | Aliases | PubMed IDs |
---|---|---|
systemic lupus erythematosus |
|