microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR657 Gene

Data sources for MIR657 Gene:

RNA type for MIR657 Gene

miRNA

Aliases for MIR657 Gene

External Ids for MIR657 Gene

Previous HGNC Symbols for MIR657 Gene

  • MIRN657

Previous GeneCards Identifiers for MIR657 Gene

  • GC17M076716
  • GC17M079099

Summaries for MIR657 Gene

Entrez Gene Summary for MIR657 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR657 Gene

MIR657 (MicroRNA 657) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR657 include Type 2 Diabetes Mellitus and Systemic Lupus Erythematosus.

Rfam classification for MIR657 Gene

Additional gene information for MIR657 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR657 Gene

Genomics for MIR657 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR657 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081126 Promoter/Enhancer 0.7 Ensembl dbSUPER 250.7 +0.1 72 0.6 KLF1 HIC1 MIR3065 MIR338 lnc-CEP131-1 MIR657 AATK BAIAP2 SLC38A10 lnc-CEP131-2 PVALEF lnc-TMEM105-1
GH17J081127 Enhancer 0.4 Ensembl dbSUPER 250.7 -1.8 -1828 0.4 ZNF600 MIR3065 MIR338 lnc-CEP131-2 MIR657 SLC38A10 AATK PVALEF BAIAP2 lnc-TMEM105-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR657 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR657 Gene

Latest Assembly
chr17:81,125,276-81,125,373
(GRCh38/hg38)
Size:
98 bases
Orientation:
Minus strand

Previous Assembly
chr17:79,099,076-79,099,173
(GRCh37/hg19 by Entrez Gene)
Size:
98 bases
Orientation:
Minus strand

chr17:79,099,076-79,099,173
(GRCh37/hg19 by Ensembl)
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR657 Gene

Genes around MIR657 on UCSC Golden Path with GeneCards custom track
MIR657 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR657 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR657 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR657 Gene

Proteins for MIR657 Gene

Post-translational modifications for MIR657 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR657 Gene

Domains & Families for MIR657 Gene

Gene Families for MIR657 Gene

HGNC:
genes like me logo Genes that share domains with MIR657: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR657 Gene

Function for MIR657 Gene

Gene Ontology (GO) - Molecular Function for MIR657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR657: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR657 Gene

Localization for MIR657 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR657 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR657 Gene

Pathways & Interactions for MIR657 Gene

PathCards logo

SuperPathways for MIR657 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation NAS 30362558
GO:0032755 positive regulation of interleukin-6 production IGI 30362558
GO:0032760 positive regulation of tumor necrosis factor production IGI 30362558
GO:0035195 gene silencing by miRNA IDA, IEA --
GO:0050727 regulation of inflammatory response IGI 30362558
genes like me logo Genes that share ontologies with MIR657: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR657 Gene

Drugs & Compounds for MIR657 Gene

No Compound Related Data Available

Transcripts for MIR657 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR657 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000070FFCE_9606 pre_miRNA 98 4

RefSeq: NR_030394,

Ensembl: ENST00000385003 (view in UCSC) ,

miRBase: MI0003681,

Rfam: RF00988,

URS000075C4C7_9606 miRNA 23 4

RefSeq: NR_030394,

LncBase: hsa-miR-657,

miRBase: MIMAT0003335,

TarBase: hsa-miR-657,

URS0001BC85AE_9606 pre_miRNA 98 1

Rfam: RF00988,

MIR657 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR657 Gene

No ASD Table

Relevant External Links for MIR657 Gene

GeneLoc Exon Structure for
MIR657

No data available for mRNA/cDNA for MIR657 Gene

Expression for MIR657 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR657 Gene

mRNA differential expression in normal tissues according to GTEx for MIR657 Gene

This gene is overexpressed in Nerve - Tibial (x9.7), Brain - Spinal cord (cervical c-1) (x5.4), Whole Blood (x5.2), Brain - Putamen (basal ganglia) (x4.6), Brain - Amygdala (x4.4), and Brain - Substantia nigra (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR657

genes like me logo Genes that share expression patterns with MIR657: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR657 Gene

Orthologs for MIR657 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR657 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-657 30
  • 99 (a)
OneToOne
Species where no ortholog for MIR657 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR657 Gene

ENSEMBL:
Gene Tree for MIR657 (if available)
TreeFam:
Gene Tree for MIR657 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR657

Paralogs for MIR657 Gene

No data available for Paralogs for MIR657 Gene

Variants for MIR657 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR657 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR657 Gene

Variant ID Type Subtype PubMed ID
dgv3292n100 CNV gain 25217958
esv26223 CNV gain+loss 19812545
nsv1065052 CNV gain 25217958
nsv1066947 CNV loss 25217958
nsv470619 CNV loss 18288195
nsv523417 CNV gain 19592680
nsv828128 CNV loss 20364138
nsv833564 CNV loss 17160897
nsv952388 CNV deletion 24416366

Additional Variant Information for MIR657 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR657
Leiden Open Variation Database (LOVD)
MIR657

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR657 Gene

Disorders for MIR657 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR657 Gene - From: MID and COP

Disorder Aliases PubMed IDs
type 2 diabetes mellitus
  • t2d
systemic lupus erythematosus
  • sle
ovarian cancer
  • ovarian cancer, somatic
schizophrenia 11
  • sczd11
schizophrenia 6
  • sczd6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR657

genes like me logo Genes that share disorders with MIR657: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR657 Gene

Publications for MIR657 Gene

  1. Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes. (PMID: 18602895) Lv K … Sun S (Biochemical and biophysical research communications 2008) 3 72
  2. Dysregulation of microRNA-657 influences inflammatory response via targeting interleukin-37 in gestational diabetes mellitus. (PMID: 30362558) Wang P … Wang Z (Journal of cellular physiology 2019) 3
  3. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  4. Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. (PMID: 24238754) Wang Y … Xiao B (Cancer genetics 2013) 3
  5. MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. (PMID: 23175432) Zhang L … Yen Y (Hepatology (Baltimore, Md.) 2013) 3

Products for MIR657 Gene

Sources for MIR657 Gene