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Aliases for MIR657 Gene

Subcategory (RNA class) for MIR657 Gene


Quality Score for this RNA gene is


Aliases for MIR657 Gene

  • MicroRNA 657 2 3 5
  • Hsa-Mir-657 3
  • MIRN657 3

External Ids for MIR657 Gene

Previous HGNC Symbols for MIR657 Gene

  • MIRN657

Previous GeneCards Identifiers for MIR657 Gene

  • GC17M076716
  • GC17M079099

Summaries for MIR657 Gene

Entrez Gene Summary for MIR657 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR657 Gene

MIR657 (MicroRNA 657) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR657 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR657

Additional gene information for MIR657 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR657 Gene

Genomics for MIR657 Gene

GeneHancer (GH) Regulatory Elements for MIR657 Gene

Promoters and enhancers for MIR657 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081125 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.8 -4.6 -4601 9.8 ZNF133 SIN3A DMAP1 BRCA1 RAD21 RARA RFX5 GLIS2 EGR1 SCRT2 AATK CEP131 LOC100294362 ENDOV PVALEF GPS1 ARL16 RFNG ENSG00000262877 BAIAP2
GH17I081122 Enhancer 0.6 dbSUPER 0.8 +2.1 2091 0.7 SCRT1 ZNF282 ZNF121 SCRT2 ZNF600 ZNF24 KDM1A EZH2 GC17M081121 ENSG00000262877 MIR657 AATK
GH17I081121 Enhancer 0.6 ENCODE dbSUPER 0.8 +3.4 3417 0 CTCF REST GC17M081121 MIR657 AATK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR657 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR657 Gene

Genomic Locations for MIR657 Gene
98 bases
Minus strand

Genomic View for MIR657 Gene

Genes around MIR657 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR657 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR657 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR657 Gene

ORGUL Member Location for MIR657 Gene

ORGUL Member Location for MIR657 gene

Proteins for MIR657 Gene

Post-translational modifications for MIR657 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR657 Gene

Domains & Families for MIR657 Gene

Gene Families for MIR657 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR657: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR657 Gene

Function for MIR657 Gene

Gene Ontology (GO) - Molecular Function for MIR657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR657: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR657 Gene

Localization for MIR657 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR657 Gene

Pathways & Interactions for MIR657 Gene

SuperPathways for MIR657 Gene

No Data Available

Interacting Proteins for MIR657 Gene

Gene Ontology (GO) - Biological Process for MIR657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20190813
genes like me logo Genes that share ontologies with MIR657: view

No data available for Pathways by source and SIGNOR curated interactions for MIR657 Gene

Drugs & Compounds for MIR657 Gene

No Compound Related Data Available

Transcripts for MIR657 Gene

fRNAdb Secondary structures for MIR657 Gene

  • hsa-mir-657_MI0003681_Homo_sapiens_miR-657_stem-loop_hairpin

mRNA/cDNA for MIR657 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR657 Gene

No ASD Table

Relevant External Links for MIR657 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR657 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR657 Gene

mRNA differential expression in normal tissues according to GTEx for MIR657 Gene

This gene is overexpressed in Nerve - Tibial (x9.7), Brain - Spinal cord (cervical c-1) (x5.4), Whole Blood (x5.2), Brain - Putamen (basal ganglia) (x4.6), Brain - Amygdala (x4.4), and Brain - Substantia nigra (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR657 Gene:

genes like me logo Genes that share expression patterns with MIR657: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR657 Gene

Orthologs for MIR657 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR657 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-657 34
  • 99 (a)
Species where no ortholog for MIR657 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR657 Gene

Gene Tree for MIR657 (if available)
Gene Tree for MIR657 (if available)

Paralogs for MIR657 Gene

No data available for Paralogs for MIR657 Gene

Variants for MIR657 Gene

Sequence variations from dbSNP and Humsavar for MIR657 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000140085 -- 81,126,020(-) G/A upstream_transcript_variant
rs1000209137 -- 81,125,138(-) C/T downstream_transcript_variant
rs1000449700 -- 81,125,854(-) C/G/T upstream_transcript_variant
rs1001322564 -- 81,126,426(-) C/T upstream_transcript_variant
rs1002940336 -- 81,127,274(-) C/A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR657 Gene

Variant ID Type Subtype PubMed ID
nsv952388 CNV deletion 24416366
nsv833564 CNV loss 17160897
nsv828128 CNV loss 20364138
nsv523417 CNV gain 19592680
nsv470619 CNV loss 18288195
nsv1066947 CNV loss 25217958
nsv1065052 CNV gain 25217958
esv26223 CNV gain+loss 19812545
dgv3292n100 CNV gain 25217958

Additional Variant Information for MIR657 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR657 Gene

Disorders for MIR657 Gene

Additional Disease Information for MIR657

No disorders were found for MIR657 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR657 Gene

Publications for MIR657 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. (PMID: 24238754) Wang Y … Xiao B (Cancer genetics 2013) 3 58
  3. MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. (PMID: 23175432) Zhang L … Yen Y (Hepatology (Baltimore, Md.) 2013) 3 58
  4. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3 58
  5. Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes. (PMID: 18602895) Lv K … Sun S (Biochemical and biophysical research communications 2008) 3 58

Products for MIR657 Gene

Sources for MIR657 Gene

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