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Aliases for MIR654 Gene

Subcategory (RNA class) for MIR654 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR654 Gene

  • MicroRNA 654 2 3 5
  • Hsa-Mir-654 3
  • Mir-654 3
  • MIRN654 3

External Ids for MIR654 Gene

ORGUL Members for MIR654 Gene

Previous HGNC Symbols for MIR654 Gene

  • MIRN654

Previous GeneCards Identifiers for MIR654 Gene

  • GC14P100822
  • GC14P100913
  • GC14P101511
  • GC14P101568
  • GC14P101601
  • GC14P101638
  • GC14P101666
  • GC14P101701
  • GC14P101738
  • GC14P101778
  • GC14P101836
  • GC14P101976
  • GC14P102174
  • GC14P101249
  • GC14P101856
  • GC14P102107
  • GC14P102345
  • GC14P102515
  • GC14P102694
  • GC14P102862
  • GC14P103038

Summaries for MIR654 Gene

Entrez Gene Summary for MIR654 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR654 Gene

MIR654 (MicroRNA 654) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR654 include Systemic Lupus Erythematosus.

Additional gene information for MIR654 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR654 Gene

Genomics for MIR654 Gene

GeneHancer (GH) Regulatory Elements for MIR654 Gene

Promoters and enhancers for MIR654 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101287 Enhancer 1 ENCODE 9.4 +248.7 248702 2.5 FOXA2 MLX ZFP64 ARID4B ZNF48 ETS1 YY1 NFKBIZ RXRA SP5 MEG3 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR655 MIR1185-1 MIR300
GH14J101333 Enhancer 0.9 ENCODE 8.9 +294.8 294838 2.2 FOXA2 ARID4B YY1 NFKBIZ RXRA SP5 PPARG NFIL3 MIER3 RCOR2 ENSG00000258460 GC14M101304 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR376C MIR1185-1
GH14J101215 Enhancer 0.8 ENCODE 9.9 +176.5 176505 2.8 FOXA2 ARID4B RAD21 ZNF48 ZSCAN9 RARA CREM RXRA CEBPB NR2F2 LOC100128373 SNORD113-3 SNORD113-8 SNORD113-9 SNORD113-4 SNORD113-6 SNORD113-7 MIR543 ENSG00000222185 ENSG00000222095
GH14J101004 Enhancer 0.7 Ensembl ENCODE 10.9 -35.1 -35134 1.9 GATA3 MNT MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14J101096 Enhancer 0.7 FANTOM5 ENCODE 10.7 +58.1 58129 3.2 ATF4 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR654 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR654 Gene

Genomic Locations for MIR654 Gene
chr14:101,040,219-101,040,299
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr14:101,506,556-101,506,636
(GRCh37/hg19)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR654 Gene

Genes around MIR654 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR654 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR654 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR654 Gene

Proteins for MIR654 Gene

Post-translational modifications for MIR654 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR654 Gene

Domains & Families for MIR654 Gene

Gene Families for MIR654 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR654: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR654 Gene

Function for MIR654 Gene

Gene Ontology (GO) - Molecular Function for MIR654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR654: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR654 Gene

Localization for MIR654 Gene

Gene Ontology (GO) - Cellular Components for MIR654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR654: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR654 Gene

Pathways & Interactions for MIR654 Gene

SuperPathways for MIR654 Gene

No Data Available

Interacting Proteins for MIR654 Gene

Gene Ontology (GO) - Biological Process for MIR654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20190813
genes like me logo Genes that share ontologies with MIR654: view

No data available for Pathways by source and SIGNOR curated interactions for MIR654 Gene

Drugs & Compounds for MIR654 Gene

No Compound Related Data Available

Transcripts for MIR654 Gene

mRNA/cDNA for MIR654 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR654 Gene

No ASD Table

Relevant External Links for MIR654 Gene

GeneLoc Exon Structure for
MIR654
ECgene alternative splicing isoforms for
MIR654

Expression for MIR654 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR654 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR654 Gene:

MIR654
genes like me logo Genes that share expression patterns with MIR654: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR654 Gene

Orthologs for MIR654 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR654 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-654 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-654 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir654 34
  • 74 (a)
OneToOne
Species where no ortholog for MIR654 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR654 Gene

ENSEMBL:
Gene Tree for MIR654 (if available)
TreeFam:
Gene Tree for MIR654 (if available)

Paralogs for MIR654 Gene

No data available for Paralogs for MIR654 Gene

Variants for MIR654 Gene

Sequence variations from dbSNP and Humsavar for MIR654 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000454623 -- 101,038,656(+) G/A/T upstream_transcript_variant
rs1003009472 -- 101,039,870(+) T/C upstream_transcript_variant
rs1005972957 -- 101,040,739(+) G/A downstream_transcript_variant
rs1006274237 -- 101,040,361(+) G/A downstream_transcript_variant
rs1008717797 -- 101,038,899(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR654 Gene

Variant ID Type Subtype PubMed ID
nsv565860 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv1040993 CNV gain 25217958
esv3635521 CNV gain 21293372

Additional Variant Information for MIR654 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR654

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR654 Gene

Disorders for MIR654 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR654 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR654

genes like me logo Genes that share disorders with MIR654: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR654 Gene

Publications for MIR654 Gene

  1. miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling. (PMID: 29364705) Lu M … Wang J (DNA and cell biology 2018) 3 58
  2. Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer. (PMID: 28030816) Geraldo MV … Kimura ET (Oncotarget 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID: 24166498) Formosa A … Candi E (Oncogene 2014) 3 58
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58

Products for MIR654 Gene

Sources for MIR654 Gene

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