microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6516 Gene

Subcategory (RNA class) for MIR6516 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR6516 Gene

  • MicroRNA 6516 2 3 5
  • MicroRNA Mir-6516 3
  • Hsa-MiR-6516-3p 168
  • Hsa-MiR-6516-5p 168
  • Hsa-Mir-6516 3
  • MIMAT0030417 53
  • MIMAT0030418 53
  • MI0025513 53
  • MIR6516 2

External Ids for MIR6516 Gene

Previous GeneCards Identifiers for MIR6516 Gene

  • GC17U902077

Summaries for MIR6516 Gene

Entrez Gene Summary for MIR6516 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6516 Gene

MIR6516 (MicroRNA 6516) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR6516 Gene

  • Small Cajal body specific RNA 16

Additional gene information for MIR6516 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR6516 Gene

Genomics for MIR6516 Gene

GeneHancer (GH) Regulatory Elements for MIR6516 Gene

Promoters and enhancers for MIR6516 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J077085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -0.9 -925 5.1 SIN3A SP1 ZBTB40 CTCF SREBF1 LCORL MLX RBPJ POLR2A USF2 SNHG20 MIR6516 SCARNA16 SEC14L1 SRSF2 MFSD11 METTL23 SEPTIN9 ENSG00000261335 SNHG16
GH17J077092 Enhancer 0.8 Ensembl dbSUPER 0.6 +2.7 2684 0.2 SP7 ZSCAN21 PRDM1 CREB1 ZEB2 ZNF629 ATF7 ZBTB48 ZBTB10 ZEB1 RF00017-2562 MIR6516 SEC14L1 lnc-SRSF2-6 SNHG20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6516 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6516 Gene

Genomic Locations for MIR6516 Gene
chr17:77,089,417-77,089,497
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR6516 Gene

Genes around MIR6516 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6516 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6516 Gene

Proteins for MIR6516 Gene

Post-translational modifications for MIR6516 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6516 Gene

Domains & Families for MIR6516 Gene

Gene Families for MIR6516 Gene

HGNC:
genes like me logo Genes that share domains with MIR6516: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6516 Gene

Function for MIR6516 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6516 Gene

Localization for MIR6516 Gene

Gene Ontology (GO) - Cellular Components for MIR6516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with MIR6516: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR6516 Gene

Pathways & Interactions for MIR6516 Gene

PathCards logo

SuperPathways for MIR6516 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6516 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with MIR6516: view

No data available for Pathways by source and SIGNOR curated interactions for MIR6516 Gene

Drugs & Compounds for MIR6516 Gene

No Compound Related Data Available

Transcripts for MIR6516 Gene

mRNA/cDNA for MIR6516 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6516 Gene

No ASD Table

Relevant External Links for MIR6516 Gene

GeneLoc Exon Structure for
MIR6516
ECgene alternative splicing isoforms for
MIR6516

Expression for MIR6516 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6516 Gene:

MIR6516
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6516 Gene

Orthologs for MIR6516 Gene

Evolution for MIR6516 Gene

ENSEMBL:
Gene Tree for MIR6516 (if available)
TreeFam:
Gene Tree for MIR6516 (if available)

No data available for Orthologs for MIR6516 Gene

Paralogs for MIR6516 Gene

No data available for Paralogs for MIR6516 Gene

Variants for MIR6516 Gene

Sequence variations from dbSNP and Humsavar for MIR6516 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001907131 -- 77,087,470(+) G/C upstream_transcript_variant
rs1002738301 -- 77,087,618(+) C/T upstream_transcript_variant
rs1003774758 -- 77,088,823(+) G/C/T upstream_transcript_variant
rs1004148442 -- 77,088,972(+) C/T upstream_transcript_variant
rs1005880365 -- 77,087,639(+) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6516 Gene

Variant ID Type Subtype PubMed ID
dgv5784n54 CNV gain 21841781
esv3582914 CNV loss 25503493
esv3641304 CNV gain 21293372

Additional Variant Information for MIR6516 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6516

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6516 Gene

Disorders for MIR6516 Gene

Additional Disease Information for MIR6516

No disorders were found for MIR6516 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6516 Gene

Publications for MIR6516 Gene

  1. The repertoire and features of human platelet microRNAs. (PMID: 23226537) Plé H … Provost P (PloS one 2012) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR6516 Gene

Sources for MIR6516 Gene