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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6514 (MicroRNA 6514) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J062790 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +1.1 | 1121 | 2.9 | TBP MXD4 SMAD5 ETS1 MBD2 ZNF217 POLR2A ELF1 THAP11 ARNT | TMEM223 MN297054 MIR6514 MIR6748 lnc-TMEM223-1 piR-55414 BSCL2 SNHG1 NXF1 CSKMT |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075BA81_9606 | precursor_RNA | 70 | 4 |
RefSeq: NR_106769, Ensembl: ENST00000622549 (view in UCSC) , miRBase: MI0022226, |
URS000075B538_9606 | miRNA | 23 | 4 |
RefSeq: NR_106769, LncBase: hsa-miR-6514-5p, miRBase: MIMAT0025484, |
URS000075C48C_9606 | miRNA | 21 | 3 |
RefSeq: NR_106769, miRBase: MIMAT0025485, ENA: LM611752.1:50..70:ncRNA, |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs369105346 | Likely Benign: not provided | 62,792,705(-) |
G/T NM_006362.5(NXF1):c.1761-4C>A |
NON_CODING_TRANSCRIPT_VARIANT,INTRON |
No disorders were found for MIR6514 Gene.