microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6511B1 Gene

Subcategory (RNA class) for MIR6511B1 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR6511B1 Gene

  • MicroRNA 6511b-1 2 3 5
  • MicroRNA Mir-6511b-1 3
  • Hsa-MiR-6511b-3p 166
  • Hsa-Mir-6511b-1 3
  • MIMAT0025848 51
  • MIMAT0025847 51
  • Mir-6511b-1 3
  • MIR6511B-1 3
  • MIR6511B1 2
  • MI0022552 51

External Ids for MIR6511B1 Gene

Previous GeneCards Identifiers for MIR6511B1 Gene

  • GC16U901773
  • GC16M002088

Summaries for MIR6511B1 Gene

Entrez Gene Summary for MIR6511B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6511B1 Gene

MIR6511B1 (MicroRNA 6511b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Cargo trafficking to the periciliary membrane.

Additional gene information for MIR6511B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6511B1 Gene

Genomics for MIR6511B1 Gene

GeneHancer (GH) Regulatory Elements for MIR6511B1 Gene

Promoters and enhancers for MIR6511B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002106 Enhancer 0.4 Ensembl ENCODE 500.7 -0.7 -704 1 ZFHX2 MIR6511B1 lnc-NTHL1-5 MLST8 ENSG00000261123 LOC105371049 ENSG00000261240 PKD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6511B1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6511B1 Gene

Genomic Locations for MIR6511B1 Gene
chr16:2,106,669-2,106,753
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR6511B1 Gene

Genes around MIR6511B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6511B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6511B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6511B1 Gene

Proteins for MIR6511B1 Gene

Post-translational modifications for MIR6511B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6511B1 Gene

Domains & Families for MIR6511B1 Gene

Gene Families for MIR6511B1 Gene

HGNC:
genes like me logo Genes that share domains with MIR6511B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6511B1 Gene

Function for MIR6511B1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6511B1 Gene

Localization for MIR6511B1 Gene

Gene Ontology (GO) - Cellular Components for MIR6511B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR6511B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR6511B1 Gene

Pathways & Interactions for MIR6511B1 Gene

genes like me logo Genes that share pathways with MIR6511B1: view
;

Gene Ontology (GO) - Biological Process for MIR6511B1 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6511B1 Gene

Drugs & Compounds for MIR6511B1 Gene

No Compound Related Data Available

Transcripts for MIR6511B1 Gene

mRNA/cDNA for MIR6511B1 Gene

4 RNACentral transcripts :
2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
8 ENA transcripts :
1 LncBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6511B1 Gene

No ASD Table

Relevant External Links for MIR6511B1 Gene

GeneLoc Exon Structure for
MIR6511B1

Expression for MIR6511B1 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6511B1 Gene

Orthologs for MIR6511B1 Gene

Evolution for MIR6511B1 Gene

ENSEMBL:
Gene Tree for MIR6511B1 (if available)
TreeFam:
Gene Tree for MIR6511B1 (if available)

No data available for Orthologs for MIR6511B1 Gene

Paralogs for MIR6511B1 Gene

No data available for Paralogs for MIR6511B1 Gene

Variants for MIR6511B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6511B1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
811806 Pathogenic: Polycystic kidney disease, adult type 2,106,673(-) C/T NONSENSE,NON_CODING_TRANSCRIPT_VARIANT
rs1555453244 Uncertain Significance: not specified 2,106,673(-) C/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1555453254 Uncertain Significance: not specified 2,106,686(-) A/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs370411414 Benign: not provided 2,106,684(-) G/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs752690118 Likely Benign: not specified 2,106,687(-) G/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR6511B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6511B1 Gene

Variant ID Type Subtype PubMed ID
dgv2755n100 CNV gain 25217958
dgv2765n100 CNV gain 25217958
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
esv1009851 CNV loss 20482838
esv2422427 CNV duplication 17116639
esv2602193 CNV loss 19546169
esv26918 CNV gain+loss 19812545
esv2758632 CNV gain+loss 17122850
esv2762254 CNV gain+loss 21179565
esv3570354 CNV gain 25503493
esv3638024 CNV loss 21293372
esv3638025 CNV gain 21293372
nsv1036298 CNV gain 25217958
nsv1038955 CNV loss 25217958
nsv1050325 CNV loss 25217958
nsv1052260 CNV gain 25217958
nsv1053467 CNV loss 25217958
nsv1115491 CNV duplication 24896259
nsv1153482 CNV duplication 26484159
nsv1160329 CNV deletion 26073780
nsv457349 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv471381 CNV gain 19718026
nsv482186 CNV gain 20164927
nsv511045 OTHER complex 20534489
nsv571190 CNV loss 21841781
nsv7277 OTHER inversion 18451855
nsv820654 CNV deletion 20802225
nsv827505 CNV gain 20364138
nsv9359 CNV gain+loss 18304495
nsv952901 CNV deletion 24416366
nsv952934 CNV deletion 24416366
nsv977911 CNV duplication 23825009
nsv984250 CNV duplication 23825009

Additional Variant Information for MIR6511B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6511B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6511B1 Gene

Disorders for MIR6511B1 Gene

Additional Disease Information for MIR6511B1

No disorders were found for MIR6511B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6511B1 Gene

Publications for MIR6511B1 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 54
  2. Deep sequencing analysis of small non-coding RNAs reveals the diversity of microRNAs and piRNAs in the human epididymis. (PMID: 22313525) Li Y … Li JY (Gene 2012) 3 54
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR6511B1 Gene

Sources for MIR6511B1 Gene