microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6506 Gene

Subcategory (RNA class) for MIR6506 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6506 Gene

  • MicroRNA 6506 2 3 5
  • Hsa-Mir-6506 2 3
  • MIR6506 2 5
  • MicroRNA Mir-6506 3
  • MIMAT0025469 50
  • MIMAT0025468 50
  • MI0022218 50

External Ids for MIR6506 Gene

Previous GeneCards Identifiers for MIR6506 Gene

  • GC16U901692

Summaries for MIR6506 Gene

Entrez Gene Summary for MIR6506 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6506 Gene

MIR6506 (MicroRNA 6506) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6506 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6506 Gene

Genomics for MIR6506 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6506 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J015607 Enhancer 1.1 Ensembl ENCODE 600.7 +1.7 1667 6.1 GATAD2A ATF7 ZNF629 TFE3 SOX13 NFKBIZ RCOR2 ZNF7 RXRB IRF2 ENSG00000257769 MIR6506 lnc-MYH11-1 ENSG00000263335 BMERB1 PLA2G10 lnc-NDE1-4 MARF1
GH16J015617 Enhancer 0.7 Ensembl ENCODE 0.4 -7.8 -7770 1.9 CEBPB FOS ZNF282 PTBP1 BCOR BHLHE40 ZMYM3 ADNP ZNF16 KDM1A ENSG00000263335 LOC100505915 PARN RRN3 CEP20 PKD1P6 RF00017-1986 MIR6506 ENSG00000257769 MARF1
GH16J015613 Enhancer 0.3 Ensembl ENCODE 0.7 -2.9 -2906 1.4 ENSG00000263335 LOC100505915 MIR6506 ENSG00000257769 RF00017-1986 MARF1 BMERB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6506 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6506 Gene

Genomic Locations for MIR6506 Gene
chr16:15,611,030-15,611,095
(GRCh38/hg38)
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR6506 Gene

Genes around MIR6506 on UCSC Golden Path with GeneCards custom track
MIR6506 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6506 Gene

Proteins for MIR6506 Gene

Post-translational modifications for MIR6506 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6506 Gene

Domains & Families for MIR6506 Gene

Gene Families for MIR6506 Gene

HGNC:
genes like me logo Genes that share domains with MIR6506: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6506 Gene

Function for MIR6506 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6506 Gene

Localization for MIR6506 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6506 Gene

Pathways & Interactions for MIR6506 Gene

PathCards logo

SuperPathways for MIR6506 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6506 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6506 Gene

Drugs & Compounds for MIR6506 Gene

No Compound Related Data Available

Transcripts for MIR6506 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6506 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B6F9_9606 precursor_RNA 66 4

HGNC: 50158,

RefSeq: NR_106761,

Ensembl: ENST00000614811 (view in UCSC) ,

miRBase: MI0022218,

URS000075D6B3_9606 miRNA 23 2

RefSeq: NR_106761,

miRBase: MIMAT0025468,

URS000075DC71_9606 miRNA 22 2

RefSeq: NR_106761,

miRBase: MIMAT0025469,

MIR6506 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6506 Gene

No ASD Table

Relevant External Links for MIR6506 Gene

GeneLoc Exon Structure for
MIR6506

No data available for mRNA/cDNA for MIR6506 Gene

Expression for MIR6506 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6506 Gene

Orthologs for MIR6506 Gene

Evolution for MIR6506 Gene

ENSEMBL:
Gene Tree for MIR6506 (if available)
TreeFam:
Gene Tree for MIR6506 (if available)

No data available for Orthologs for MIR6506 Gene

Paralogs for MIR6506 Gene

No data available for Paralogs for MIR6506 Gene

Variants for MIR6506 Gene

Additional dbSNP identifiers (rs#s) for MIR6506 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6506 Gene

Variant ID Type Subtype PubMed ID
dgv4924n54 CNV gain 21841781
esv2714015 CNV deletion 23290073
esv3638034 CNV gain 21293372
esv3638038 CNV gain 21293372
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv469626 CNV loss 16826518
nsv819327 CNV loss 19587683

Additional Variant Information for MIR6506 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6506

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6506 Gene

Disorders for MIR6506 Gene

Additional Disease Information for MIR6506

No disorders were found for MIR6506 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6506 Gene

Publications for MIR6506 Gene

  1. Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506-5p/FOXO3 axis. (PMID: 30853185) Lu J … Zheng CH (Biochemical and biophysical research communications 2019) 3
  2. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce CE … Bowcock AM (Human molecular genetics 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6506 Gene

Sources for MIR6506 Gene