microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6503 Gene

Subcategory (RNA class) for MIR6503 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR6503 Gene

  • MicroRNA 6503 2 3 5
  • MicroRNA Mir-6503 3
  • Hsa-Mir-6503 3
  • MIMAT0025462 53
  • MIMAT0025463 53
  • MI0022215 53
  • MIR6503 2

External Ids for MIR6503 Gene

Previous GeneCards Identifiers for MIR6503 Gene

  • GC11U902141

Summaries for MIR6503 Gene

Entrez Gene Summary for MIR6503 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6503 Gene

MIR6503 (MicroRNA 6503) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6503 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6503 Gene

Genomics for MIR6503 Gene

GeneHancer (GH) Regulatory Elements for MIR6503 Gene

Promoters and enhancers for MIR6503 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J060208 Enhancer 0.2 Ensembl 750.6 +0.4 355 1.6 MIR6503 OOSP2 MS4A6A MS4A4A piR-55655-088 MS4A4E
GH11J060204 Enhancer 0.9 Ensembl dbSUPER 0.6 +3.5 3455 2.6 JUND RELA CREM ZBED1 IKZF1 BACH1 TRIM22 IKZF2 PKNOX1 CBFB TCN1 OOSP2 MS4A6A MS4A4E MIR6503 piR-55655-088 MS4A4A
GH11J060243 Promoter/Enhancer 0.7 EPDnew ENCODE 0.3 -33.9 -33927 0.2 TEAD4 ZNF639 HDAC1 MS4A4E MIR6503 MS4A4A
GH11J060220 Enhancer 0.5 Ensembl 0.4 -13.3 -13345 3.4 FOSL1 CEBPG CEBPB FOS JUN MS4A6E MS4A6A MS4A4A MS4A4E MIR6503
GH11J060242 Promoter 0.4 Ensembl 0.3 -33.5 -33545 0.2 ZNF639 MS4A4E MIR6503 MS4A4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6503 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR6503 Gene

Genomic Locations for MIR6503 Gene
chr11:60,209,071-60,209,156
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR6503 Gene

Genes around MIR6503 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6503 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6503 Gene

Proteins for MIR6503 Gene

Post-translational modifications for MIR6503 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6503 Gene

Domains & Families for MIR6503 Gene

Gene Families for MIR6503 Gene

HGNC:
genes like me logo Genes that share domains with MIR6503: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6503 Gene

Function for MIR6503 Gene

Phenotypes From GWAS Catalog for MIR6503 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6503 Gene

Localization for MIR6503 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6503 Gene

Pathways & Interactions for MIR6503 Gene

PathCards logo

SuperPathways for MIR6503 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6503 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR6503 Gene

Drugs & Compounds for MIR6503 Gene

No Compound Related Data Available

Transcripts for MIR6503 Gene

mRNA/cDNA for MIR6503 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(5) ENA transcripts :
(3) miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6503 Gene

No ASD Table

Relevant External Links for MIR6503 Gene

GeneLoc Exon Structure for
MIR6503
ECgene alternative splicing isoforms for
MIR6503

Expression for MIR6503 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6503 Gene:

MIR6503
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6503 Gene

Orthologs for MIR6503 Gene

Evolution for MIR6503 Gene

ENSEMBL:
Gene Tree for MIR6503 (if available)
TreeFam:
Gene Tree for MIR6503 (if available)

No data available for Orthologs for MIR6503 Gene

Paralogs for MIR6503 Gene

No data available for Paralogs for MIR6503 Gene

Variants for MIR6503 Gene

Sequence variations from dbSNP and Humsavar for MIR6503 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000048184 -- 60,209,558(-) T/C upstream_transcript_variant
rs1000426054 -- 60,210,094(-) C/G/T upstream_transcript_variant
rs1000854723 -- 60,208,768(-) T/C downstream_transcript_variant
rs1001642733 -- 60,209,733(-) T/C upstream_transcript_variant
rs1001695088 -- 60,209,448(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR6503 Gene

Variant ID Type Subtype PubMed ID
nsv832174 CNV gain 17160897
nsv983028 CNV duplication 23825009

Additional Variant Information for MIR6503 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6503

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6503 Gene

Disorders for MIR6503 Gene

Additional Disease Information for MIR6503

No disorders were found for MIR6503 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6503 Gene

Publications for MIR6503 Gene

  1. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce CE … Bowcock AM (Human molecular genetics 2011) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR6503 Gene

Sources for MIR6503 Gene