microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6501 Gene

Data sources for MIR6501 Gene:

RNA type for MIR6501 Gene

miRNA

Aliases for MIR6501 Gene

External Ids for MIR6501 Gene

Previous GeneCards Identifiers for MIR6501 Gene

  • GC21U900594

Summaries for MIR6501 Gene

Entrez Gene Summary for MIR6501 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6501 Gene

MIR6501 (MicroRNA 6501) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR6501 include Zttk Syndrome.

Additional gene information for MIR6501 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6501 Gene

Genomics for MIR6501 Gene

Genomic Locations for MIR6501 Gene

Latest Assembly
chr21:33,550,662-33,550,728
(GRCh38/hg38)
Size:
67 bases
Orientation:
Plus strand

Previous Assembly
chr21:34,922,968-34,923,034
(GRCh37/hg19 by Entrez Gene)
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR6501 Gene

Genes around MIR6501 on UCSC Golden Path with GeneCards custom track
MIR6501 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6501 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6501 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6501 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR6501 Gene

Proteins for MIR6501 Gene

Post-translational modifications for MIR6501 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6501 Gene

Domains & Families for MIR6501 Gene

Gene Families for MIR6501 Gene

HGNC:
genes like me logo Genes that share domains with MIR6501: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6501 Gene

Function for MIR6501 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6501 Gene

Localization for MIR6501 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6501 Gene

Pathways & Interactions for MIR6501 Gene

PathCards logo

SuperPathways for MIR6501 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6501 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6501 Gene

Drugs & Compounds for MIR6501 Gene

No Compound Related Data Available

Transcripts for MIR6501 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6501 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075BDAA_9606 pre_miRNA 67 4

RefSeq: NR_106756,

Ensembl: ENST00000290239 (view in UCSC) ,

miRBase: MI0022213,

ENA: LM611744.1:1..67:precursor_RNA,

URS000075C286_9606 miRNA 22 4

RefSeq: NR_106756,

LncBase: hsa-miR-6501-5p,

miRBase: MIMAT0025458,

ENA: LM611744.1:3..24:ncRNA,

URS000075EBDF_9606 miRNA 23 3

RefSeq: NR_106756,

miRBase: MIMAT0025459,

ENA: LM383115.1:1..23:ncRNA, LM611744.1:44..66:ncRNA,

MIR6501 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR6501 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6501 Gene

No ASD Table

Relevant External Links for MIR6501 Gene

GeneLoc Exon Structure for
MIR6501

Expression for MIR6501 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6501 Gene

Orthologs for MIR6501 Gene

Evolution for MIR6501 Gene

ENSEMBL:
Gene Tree for MIR6501 (if available)
TreeFam:
Gene Tree for MIR6501 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR6501

No data available for Orthologs for MIR6501 Gene

Paralogs for MIR6501 Gene

No data available for Paralogs for MIR6501 Gene

Variants for MIR6501 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR6501 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
617862 Likely Pathogenic: ZTTK syndrome 33,550,229(+) CAATTGAAGCGCTAAG
NM_138927.4(SON):c.1002_5016del (p.Glu335fs)
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs1555898280 Pathogenic: not provided 33,550,717(+) GC/G
NM_001291412.2(SON):c.244+4339del
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6501 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6501 Gene

Variant ID Type Subtype PubMed ID
nsv1078502 CNV duplication 25765185
nsv1115615 CNV duplication 24896259

Additional Variant Information for MIR6501 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6501
Leiden Open Variation Database (LOVD)
MIR6501

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6501 Gene

Disorders for MIR6501 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR6501 Gene - From: GCD

Disorder Aliases PubMed IDs
zttk syndrome
  • zttks
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR6501

genes like me logo Genes that share disorders with MIR6501: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR6501 Gene

Publications for MIR6501 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce CE … Bowcock AM (Human molecular genetics 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6501 Gene

Sources for MIR6501 Gene