MIR648 Gene (RNA Gene)

MicroRNA 648

GC22M017980
GIFtS:
15
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR648 Gene

Subcategory (RNA class) for MIR648 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR648 Gene

  • MicroRNA 648 2 3 5
  • Hsa-Mir-648 2 3
  • MIR648 2 5
  • MIMAT0003318 50
  • Hsa-MiR-648 173
  • MI0003663 50
  • MIRN648 3
  • RF00970 168

External Ids for MIR648 Gene

Previous HGNC Symbols for MIR648 Gene

  • MIRN648

Previous GeneCards Identifiers for MIR648 Gene

  • GC22M016844
  • GC22M018463

Summaries for MIR648 Gene

Entrez Gene Summary for MIR648 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR648 Gene

MIR648 (MicroRNA 648) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR648 include Ovarian Cancer.

Rfam classification for MIR648 Gene

Additional gene information for MIR648 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR648 Gene

Genomics for MIR648 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR648 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22J017979 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 600.7 +0.6 623 1.8 HNRNPL PRDM10 LEF1 IKZF1 ETV6 JUND DDX20 PRDM1 MTA2 PKNOX1 MIR648 MICAL3 lnc-PEX26-5 BID
GH22J017937 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.4 +33.5 33460 19.8 GATAD2A ATF7 PRDM10 ZNF629 REST PRDM1 ZIC2 ZSCAN4 PKNOX1 POLR2A piR-48739 MICAL3 MIR648 ENSG00000093100 HDHD5-AS1 piR-59398 piR-61101-445 BID
GH22J018003 Enhancer 0.3 Ensembl dbSUPER 12.4 -23.0 -23040 0.8 lnc-PEX26-3 lnc-PEX26-4 MICAL3 MIR648 ENSG00000093100 ENSG00000234913 BID
GH22J017976 Enhancer 0.7 Ensembl dbSUPER 0.7 +3.6 3560 1.2 ZNF7 ZNF184 ZBTB33 KLF1 EGR1 SMARCA5 MLLT1 MICAL3 LINC01634 MIR648 lnc-PEX26-5 BID
GH22J017982 Enhancer 0.2 dbSUPER 0.7 -2.4 -2409 1.1 ENSG00000235445 MICAL3 ENSG00000093100 MIR648 BID
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR648 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR648 Gene

Genomic Locations for MIR648 Gene
chr22:17,980,868-17,980,961
(GRCh38/hg38)
Size:
94 bases
Orientation:
Minus strand
chr22:18,463,634-18,463,727
(GRCh37/hg19)
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR648 Gene

Genes around MIR648 on UCSC Golden Path with GeneCards custom track
MIR648 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR648 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR648 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR648 Gene

Proteins for MIR648 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR648 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR648 Gene

Domains & Families for MIR648 Gene

Gene Families for MIR648 Gene

HGNC:
genes like me logo Genes that share domains with MIR648: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR648 Gene

Function for MIR648 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR648 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR648 Gene

Localization for MIR648 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR648 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR648 Gene

Pathways & Interactions for MIR648 Gene

PathCards logo

SuperPathways for MIR648 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR648 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR648: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR648 Gene

Drugs & Compounds for MIR648 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR648 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR648 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000063524F_9606 precursor_RNA 94 5

HGNC: 32904,

RefSeq: NR_030378,

Ensembl: ENST00000385046 (view in UCSC) ,

miRBase: MI0003663,

Rfam: RF00970,

URS000075E498_9606 miRNA 19 3

RefSeq: NR_030378,

miRBase: MIMAT0003318,

TarBase: hsa-miR-648,

MIR648 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR648 Gene

No ASD Table

Relevant External Links for MIR648 Gene

GeneLoc Exon Structure for
MIR648

No data available for mRNA/cDNA for MIR648 Gene

Expression for MIR648 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR648 Gene

mRNA expression in normal human tissues for MIR648 Gene
mRNA expression by GTEx for MIR648 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR648

genes like me logo Genes that share expression patterns with MIR648: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR648 Gene

Orthologs for MIR648 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR648 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 98 (a)
 OneToOne
Species where no ortholog for MIR648 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR648 Gene

ENSEMBL:
Gene Tree for MIR648 (if available)
TreeFam:
Gene Tree for MIR648 (if available)

Paralogs for MIR648 Gene

No data available for Paralogs for MIR648 Gene

Variants for MIR648 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for MIR648 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR648 Gene

Variant ID Type Subtype PubMed ID
esv3575408 CNV gain 25503493
esv3893428 CNV loss 25118596
nsv428385 CNV gain+loss 18775914

Additional Variant Information for MIR648 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR648

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR648 Gene

Disorders for MIR648 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR648 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR648

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR648: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR648 Gene

Publications for MIR648 Gene

  1. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. (PMID: 25403488) Li C … Kalra VK (Molecular and cellular biology 2015) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

ExternalLinks

View latest publications for MIR648 gene in Mastermind

Products for MIR648 Gene

Sources for MIR648 Gene