Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR648 (MicroRNA 648) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR648 include Ovarian Cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH22J017979 | Promoter/Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 600.7 | +0.6 | 623 | 1.8 | HNRNPL PRDM10 LEF1 IKZF1 ETV6 JUND DDX20 PRDM1 MTA2 PKNOX1 | MIR648 MICAL3 lnc-PEX26-5 BID | |
GH22J017937 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 12.4 | +33.5 | 33460 | 19.8 | GATAD2A ATF7 PRDM10 ZNF629 REST PRDM1 ZIC2 ZSCAN4 PKNOX1 POLR2A | piR-48739 MICAL3 MIR648 ENSG00000093100 HDHD5-AS1 piR-59398 piR-61101-445 BID | |
GH22J018003 | Enhancer | 0.3 | Ensembl dbSUPER | 12.4 | -23.0 | -23040 | 0.8 | lnc-PEX26-3 lnc-PEX26-4 MICAL3 MIR648 ENSG00000093100 ENSG00000234913 BID | ||
GH22J017976 | Enhancer | 0.7 | Ensembl dbSUPER | 0.7 | +3.6 | 3560 | 1.2 | ZNF7 ZNF184 ZBTB33 KLF1 EGR1 SMARCA5 MLLT1 | MICAL3 LINC01634 MIR648 lnc-PEX26-5 BID | |
GH22J017982 | Enhancer | 0.2 | dbSUPER | 0.7 | -2.4 | -2409 | 1.1 | ENSG00000235445 MICAL3 ENSG00000093100 MIR648 BID |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000063524F_9606 | precursor_RNA | 94 | 5 |
HGNC: 32904, RefSeq: NR_030378, Ensembl: ENST00000385046 (view in UCSC) , miRBase: MI0003663, Rfam: RF00970, |
URS000075E498_9606 | miRNA | 19 | 3 |
RefSeq: NR_030378, miRBase: MIMAT0003318, TarBase: hsa-miR-648, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3575408 | CNV | gain | 25503493 |
esv3893428 | CNV | loss | 25118596 |
nsv428385 | CNV | gain+loss | 18775914 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|