Aliases for MIR648 Gene
Subcategory (RNA class) for MIR648 Gene
miRNA
Quality Score for this RNA gene is
8
External Ids for MIR648 Gene
- HGNC: 32904
- Entrez Gene: 693233
- Ensembl: ENSG00000207780
- OMIM: 616205
- miRBase: hsa-mir-648
ORGUL Members for MIR648 Gene
Previous HGNC Symbols for MIR648 Gene
- MIRN648
Previous GeneCards Identifiers for MIR648 Gene
- GC22M016844
- GC22M018463
Summaries for MIR648 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR648 Gene
MIR648 (MicroRNA 648) is an RNA Gene, and is affiliated with the miRNA class.
fRNAdb sequence ontologies for MIR648 Gene
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR648 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR648 Gene
Genomics for MIR648 Gene
GeneHancer (GH) Regulatory Elements for MIR648 Gene
Promoters and enhancers for MIR648 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22I017979 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 550.8 | +0.6 | 623 | 1.8 | HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 ZNF766 GATA2 E2F8 ATF7 | MIR648 MICAL3 PIR53397 | |
| GH22I017981 | Enhancer | 0.5 | Ensembl dbSUPER | 550.8 | -0.7 | -740 | 0.2 | POLR2A | MIR648 ENSG00000235445 MICAL3 | |
| GH22I017942 | Enhancer | 0.4 | ENCODE dbSUPER | 12.4 | +38.3 | 38302 | 0.6 | MIR648 MICAL3 ENSG00000093100 GC22M017948 PIR41738 PIR51874 | ||
| GH22I018004 | Enhancer | 0.3 | dbSUPER | 12.4 | -22.5 | -22539 | 0.9 | ZNF121 | MICAL3 MIR648 ENSG00000093100 ENSG00000234913 ENSG00000235445 | |
| GH22I017969 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +10.7 | 10732 | 1.9 | TEAD4 TAL1 ZBTB40 ZKSCAN1 TCF12 CTBP1 ZNF766 POLR2A NCOR1 CBFA2T2 | MICAL3 ENSG00000093100 MIR648 PIR53397 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR648 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR648 Gene
Genomic Locations for MIR648 Gene
- chr22:17,980,868-17,980,961
- (GRCh38/hg38)
- Size:
- 94 bases
- Orientation:
- Minus strand
- chr22:18,463,634-18,463,727
- (GRCh37/hg19)
Genomic View for MIR648 Gene
Genes around MIR648 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by Ensembl
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC
MIR648 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR648 Gene
ORGUL Member Location for MIR648 Gene
Proteins for MIR648 Gene
Post-translational modifications for MIR648 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR648
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR648
- Origene Custom Protein Services for MIR648
- Search GeneTex for Proteins for MIR648
No data available for DME Specific Peptides for MIR648 Gene
Domains & Families for MIR648 Gene
Gene Families for MIR648 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR648 Gene
Function for MIR648 Gene
Phenotypes From GWAS Catalog for MIR648 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR648
-
- Search ViGene Biosciences for MIR648
CRISPR Products
- Browse CRISPR knockouts for MIR648
- Applied Biological Materials CRISPR for MIR648
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR648
Inhibitory RNA Products
- Search ViGene Biosciences for MIR648
Clone Products
- GenScript: Custom all cDNA clones Services for MIR648
- VectorBuilder custom plasmid, inducible vectors for MIR648
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR648
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR648
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR648 Gene
Localization for MIR648 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR648 Gene
Transcripts for MIR648 Gene
fRNAdb Secondary structures for MIR648 Gene
mRNA/cDNA for MIR648 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR648
- Applied Biological Materials CRISPR for MIR648
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR648
Inhibitory RNA Products
- Search ViGene Biosciences for MIR648
Clone Products
- GenScript: Custom all cDNA clones Services for MIR648
- VectorBuilder custom plasmid, inducible vectors for MIR648
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR648
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR648
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR648 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR648 Gene:
MIR648Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR648 Gene
Orthologs for MIR648 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToOne |
- Species where no ortholog for MIR648 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR648 Gene
No data available for Paralogs for MIR648 Gene
Variants for MIR648 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000247967 | -- | 17,981,576(-) | T/G | upstream_transcript_variant | |
| rs1000703229 | -- | 17,981,916(-) | A/G | upstream_transcript_variant | |
| rs1001305007 | -- | 17,980,477(-) | C/T | downstream_transcript_variant | |
| rs1003839247 | -- | 17,980,758(-) | G/A | downstream_transcript_variant | |
| rs1004257406 | -- | 17,982,405(-) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3575408 | CNV | gain | 25503493 |
| esv3893428 | CNV | loss | 25118596 |
| nsv428385 | CNV | gain+loss | 18775914 |
Additional Variant Information for MIR648 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR648
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR648 Gene
Disorders for MIR648 Gene
Additional Disease Information for MIR648
No disorders were found for MIR648 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR648 Gene
Publications for MIR648 Gene
- The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
- MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. (PMID: 25403488) Li C … Kalra VK (Molecular and cellular biology 2015) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
Products for MIR648 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Proteins and Enzymes
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR648
- VectorBuilder custom plasmid, inducible vectors for MIR648
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR648
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR648
- Search GeneTex for Proteins for MIR648
- Search ViGene Biosciences for MIR648
Sources for MIR648 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems