microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR645 Gene

Subcategory (RNA class) for MIR645 Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR645 Gene

  • MicroRNA 645 2 3 5
  • MIMAT0003315 51
  • Hsa-Mir-645 3
  • MI0003660 51
  • MIRN645 3
  • MIR645 2

External Ids for MIR645 Gene

Previous HGNC Symbols for MIR645 Gene

  • MIRN645

Previous GeneCards Identifiers for MIR645 Gene

  • GC20P048636
  • GC20P049202

Summaries for MIR645 Gene

Entrez Gene Summary for MIR645 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR645 Gene

MIR645 (MicroRNA 645) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR645 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR645 Gene

Genomics for MIR645 Gene

GeneHancer (GH) Regulatory Elements for MIR645 Gene

Promoters and enhancers for MIR645 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J050587 Enhancer 0.4 ENCODE 500.7 +1.6 1633 0.1 ESRRA POLR2A POLR2G MAZ FOS MIR645 lnc-ADNP-2 RIPOR3
GH20J050588 Enhancer 0.4 ENCODE 500.7 +1.5 1453 0.2 POLR2G POLR2A MAZ FOS MIR645 lnc-ADNP-2 RIPOR3
GH20J050507 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -70.4 -70435 14.7 EP300 FOXK2 ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 USF1 PTPN1 ENSG00000232043 CEBPB ADNP LINC01273 MIR645 PTGIS DPM1 PSMD10P1 LINC01275
GH20J050721 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +149.4 149399 27.8 EP300 FOXK2 ZBTB40 CTCF ZSCAN5C TCF12 NRF1 MYC POLR2G USF1 PARD6B ADNP PSMD10P1 ENSG00000232043 RIPOR3 DPM1 KRT18P4 BCAS4 MIR645 RNF114
GH20J050162 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -420.8 -420829 5.1 EP300 FOXK2 ZBTB40 ZNF217 ZSCAN5C NRF1 TCF12 POLR2G BCLAF1 NCOR1 LINC01275 ENSG00000234698 piR-57460-415 TMEM189 LINC01273 DDX27 ADNP ENSG00000232043 PTPN1 DPM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR645 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR645 Gene

Genomic Locations for MIR645 Gene
chr20:50,585,786-50,585,879
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr20:49,202,323-49,202,416
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR645 Gene

Genes around MIR645 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR645 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR645 Gene

Proteins for MIR645 Gene

Post-translational modifications for MIR645 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR645 Gene

Domains & Families for MIR645 Gene

Gene Families for MIR645 Gene

HGNC:
genes like me logo Genes that share domains with MIR645: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR645 Gene

Function for MIR645 Gene

Phenotypes From GWAS Catalog for MIR645 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR645 Gene

Localization for MIR645 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR645 Gene

Pathways & Interactions for MIR645 Gene

PathCards logo

SuperPathways for MIR645 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR645 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR645 Gene

Drugs & Compounds for MIR645 Gene

No Compound Related Data Available

Transcripts for MIR645 Gene

mRNA/cDNA for MIR645 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR645 Gene

No ASD Table

Relevant External Links for MIR645 Gene

GeneLoc Exon Structure for
MIR645

Expression for MIR645 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR645 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR645

genes like me logo Genes that share expression patterns with MIR645: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR645 Gene

Orthologs for MIR645 Gene

Evolution for MIR645 Gene

ENSEMBL:
Gene Tree for MIR645 (if available)
TreeFam:
Gene Tree for MIR645 (if available)

No data available for Orthologs for MIR645 Gene

Paralogs for MIR645 Gene

No data available for Paralogs for MIR645 Gene

Variants for MIR645 Gene

Additional dbSNP identifiers (rs#s) for MIR645 Gene

Additional Variant Information for MIR645 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR645

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR645 Gene

Disorders for MIR645 Gene

Additional Disease Information for MIR645

No disorders were found for MIR645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR645 Gene

Publications for MIR645 Gene

  1. MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation. (PMID: 30312695) Tao J … Liu Q (International journal of biological macromolecules 2019) 3 54
  2. MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2. (PMID: 29956840) Jiao GJ … Liu HC (Clinical and experimental pharmacology & physiology 2018) 3 54
  3. Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2. (PMID: 29028086) Cai Y … Liu K (European review for medical and pharmacological sciences 2017) 3 54
  4. MicroRNA-645 promotes cell metastasis and proliferation of renal clear cell carcinoma by targeting GK5. (PMID: 29131260) Chen J … Shen W (European review for medical and pharmacological sciences 2017) 3 54
  5. Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. (PMID: 27609068) Wang Y … Zhang W (Cancer letters 2016) 3 54

Products for MIR645 Gene

Sources for MIR645 Gene