microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR645 Gene

Data sources for MIR645 Gene:

Subcategory (RNA class) for MIR645 Gene

miRNA

Aliases for MIR645 Gene

External Ids for MIR645 Gene

Previous HGNC Symbols for MIR645 Gene

  • MIRN645

Previous GeneCards Identifiers for MIR645 Gene

  • GC20P048636
  • GC20P049202

Summaries for MIR645 Gene

Entrez Gene Summary for MIR645 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR645 Gene

MIR645 (MicroRNA 645) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR645 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR645 Gene

Genomics for MIR645 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR645 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J050587 Enhancer 0.4 ENCODE 250.7 +1.6 1633 0.1 MAZ ESRRA FOS POLR2A HSALNG0130786 MIR645 lnc-ADNP-2 PTPN1 RIPOR3
GH20J050588 Enhancer 0.4 ENCODE 250.7 +1.5 1453 0.2 MAZ FOS POLR2A HSALNG0130786 MIR645 lnc-ADNP-2 PTPN1 RIPOR3
GH20J050507 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -70.4 -70435 14.7 ZSCAN16 CHD2 TBP ZBTB10 BCL11A SP1 MXD4 FEZF1 ZNF217 MNT PTPN1 ADNP ENSG00000232043 DPM1 PSMD10P1 CEBPB MOCS3 LINC01273 MIR645 KRT18P4
GH20J050721 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +149.4 149399 27.8 ZSCAN16 CHD2 TBP MXD4 SP1 FEZF1 CEBPA FOXA1 MNT IKZF1 PARD6B ADNP DPM1 ENSG00000232043 MOCS3 PSMD10P1 RIPOR3 BCAS4 MIR645 RNF114
GH20J050162 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -420.8 -420829 5.1 TBP ZBTB10 MXD4 FEZF1 CEBPA ZNF217 FOXA1 MNT IKZF1 SMAD5 LINC01275 piR-57460-415 PEDS1 DDX27 ADNP ENSG00000232043 LINC01273 PSMD10P1 DPM1 PTPN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR645 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR645 Gene

Latest Assembly
chr20:50,585,786-50,585,879
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand

Previous Assembly
chr20:49,202,323-49,202,416
(GRCh37/hg19 by Entrez Gene)
Size:
94 bases
Orientation:
Plus strand

chr20:49,202,323-49,202,416
(GRCh37/hg19 by Ensembl)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR645 Gene

Genes around MIR645 on UCSC Golden Path with GeneCards custom track
MIR645 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR645 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR645 Gene

Proteins for MIR645 Gene

Post-translational modifications for MIR645 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR645 Gene

Domains & Families for MIR645 Gene

Gene Families for MIR645 Gene

HGNC:
genes like me logo Genes that share domains with MIR645: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR645 Gene

Function for MIR645 Gene

Phenotypes From GWAS Catalog for MIR645 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR645 Gene

Localization for MIR645 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR645 Gene

Pathways & Interactions for MIR645 Gene

PathCards logo

SuperPathways for MIR645 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR645 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR645 Gene

Drugs & Compounds for MIR645 Gene

No Compound Related Data Available

Transcripts for MIR645 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR645 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075AEA1_9606 pre_miRNA 94 3

RefSeq: NR_030375,

Ensembl: ENST00000385283 (view in UCSC) ,

miRBase: MI0003660,

URS000075E7D0_9606 miRNA 19 2

RefSeq: NR_030375,

miRBase: MIMAT0003315,

MIR645 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR645 Gene

No ASD Table

Relevant External Links for MIR645 Gene

GeneLoc Exon Structure for
MIR645

No data available for mRNA/cDNA for MIR645 Gene

Expression for MIR645 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR645 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR645

genes like me logo Genes that share expression patterns with MIR645: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR645 Gene

Orthologs for MIR645 Gene

Evolution for MIR645 Gene

ENSEMBL:
Gene Tree for MIR645 (if available)
TreeFam:
Gene Tree for MIR645 (if available)

No data available for Orthologs for MIR645 Gene

Paralogs for MIR645 Gene

No data available for Paralogs for MIR645 Gene

Variants for MIR645 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR645 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR645 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR645

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR645 Gene

Disorders for MIR645 Gene

Additional Disease Information for MIR645

No disorders were found for MIR645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR645 Gene

Publications for MIR645 Gene

  1. MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1. (PMID: 32529465) Wang R … Liu C (Human cell 2020) 3
  2. MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation. (PMID: 30312695) Tao J … Liu Q (International journal of biological macromolecules 2019) 3
  3. MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2. (PMID: 29956840) Jiao GJ … Liu HC (Clinical and experimental pharmacology & physiology 2018) 3
  4. Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2. (PMID: 29028086) Cai Y … Liu K (European review for medical and pharmacological sciences 2017) 3
  5. MicroRNA-645 promotes cell metastasis and proliferation of renal clear cell carcinoma by targeting GK5. (PMID: 29131260) Chen J … Shen W (European review for medical and pharmacological sciences 2017) 3

Products for MIR645 Gene

Sources for MIR645 Gene