microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR644A Gene

Subcategory (RNA class) for MIR644A Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR644A Gene

  • MicroRNA 644a 2 3 5
  • MicroRNA 644 2 3
  • Hsa-Mir-644 2 3
  • MIR644A 2 5
  • Hsa-Mir-644a 3
  • MIMAT0003314 50
  • MI0003659 50
  • MIRN644 3
  • RF01037 168
  • MIR644 3

External Ids for MIR644A Gene

Previous HGNC Symbols for MIR644A Gene

  • MIRN644
  • MIR644

Previous GeneCards Identifiers for MIR644A Gene

  • GC20P033056

Summaries for MIR644A Gene

Entrez Gene Summary for MIR644A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR644A Gene

MIR644A (MicroRNA 644a) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR644A Gene

Additional gene information for MIR644A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR644A Gene

Genomics for MIR644A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR644A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J034472 Enhancer 1 Ensembl ENCODE 0.4 +6.5 6485 2.8 GATAD2A CTCF PRDM10 ZNF629 ZNF174 JUND PRDM1 ZSCAN4 REST RAD21 piR-31162-296 piR-31432-407 piR-45471-370 piR-49732-345 piR-56759-339 piR-54764-390 MAP1LC3A DYNLRB1 NCOA6 FDX1P1
GH20J034461 Enhancer 0.9 Ensembl ENCODE 0.4 -5.2 -5182 0.7 IKZF1 MTA1 SOX6 TCF12 EP300 EGR1 CTBP1 E2F5 NCOR1 FOSL1 ITCH MIR644A ITCH-IT1 DYNLRB1 LOC107985381
GH20J034458 Enhancer 0.5 ENCODE 0.4 -7.4 -7382 1.2 ATF7 ZNF629 RBM22 ATF2 NR2F2 BHLHE40 JUN JUND ZSCAN21 MAP1LC3A DYNLRB1 ITCH MYH7B MIR644A ITCH-IT1 LOC107985381
GH20J034460 Enhancer 0.2 Ensembl 0.4 -6.2 -6224 0.2 MAP1LC3A ITCH MIR644A ITCH-IT1 DYNLRB1 LOC107985381
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR644A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR644A Gene

Genomic Locations for MIR644A Gene
chr20:34,466,325-34,466,418
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr20:33,054,130-33,054,223
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR644A Gene

Genes around MIR644A on UCSC Golden Path with GeneCards custom track
MIR644A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR644A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR644A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR644A Gene

Proteins for MIR644A Gene

Post-translational modifications for MIR644A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR644A Gene

Domains & Families for MIR644A Gene

Gene Families for MIR644A Gene

HGNC:
genes like me logo Genes that share domains with MIR644A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR644A Gene

Function for MIR644A Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR644A Gene

Localization for MIR644A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR644A Gene

Pathways & Interactions for MIR644A Gene

PathCards logo

SuperPathways for MIR644A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR644A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR644A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR644A Gene

Drugs & Compounds for MIR644A Gene

No Compound Related Data Available

Transcripts for MIR644A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR644A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000067B227_9606 precursor_RNA 94 5

HGNC: 32900,

RefSeq: NR_030374,

Ensembl: ENST00000385262 (view in UCSC) ,

miRBase: MI0003659,

Rfam: RF01037,

URS000075C3AA_9606 miRNA 19 2

RefSeq: NR_030374,

miRBase: MIMAT0003314,

MIR644A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR644A Gene

No ASD Table

Relevant External Links for MIR644A Gene

GeneLoc Exon Structure for
MIR644A

No data available for mRNA/cDNA for MIR644A Gene

Expression for MIR644A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR644A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR644A

genes like me logo Genes that share expression patterns with MIR644A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR644A Gene

Orthologs for MIR644A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR644A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR644A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR644A Gene

ENSEMBL:
Gene Tree for MIR644A (if available)
TreeFam:
Gene Tree for MIR644A (if available)

Paralogs for MIR644A Gene

No data available for Paralogs for MIR644A Gene

Variants for MIR644A Gene

Additional dbSNP identifiers (rs#s) for MIR644A Gene

Additional Variant Information for MIR644A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR644A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR644A Gene

Disorders for MIR644A Gene

Additional Disease Information for MIR644A

No disorders were found for MIR644A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR644A Gene

Publications for MIR644A Gene

  1. MiR-644a Disrupts Oncogenic Transformation and Warburg Effect by Direct Modulation of Multiple Genes of Tumor-Promoting Pathways. (PMID: 30808676) Ebron JS … Shukla GC (Cancer research 2019) 3
  2. miR-644a Inhibits Cellular Proliferation and Invasion via Suppression of CtBP1 in Gastric Cancer Cells. (PMID: 27983935) Li Y … Li Y (Oncology research 2018) 3
  3. MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1. (PMID: 29898735) Liang W … Wang Z (Cell communication and signaling : CCS 2018) 3
  4. Overexpression of Long Non-Coding RNA MEG3 Inhibits Proliferation of Hepatocellular Carcinoma Huh7 Cells via Negative Modulation of miRNA-664. (PMID: 28374914) He JH … Cao MR (Journal of cellular biochemistry 2017) 3
  5. Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressiveness and Stem Cell-like Phenotype via Dysregulation of PITX2. (PMID: 27407092) Zhang JX … Xie D (Clinical cancer research : an official journal of the American Association for Cancer Research 2017) 3

Products for MIR644A Gene

Sources for MIR644A Gene