microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR643 Gene

Data sources for MIR643 Gene:

Subcategory (RNA class) for MIR643 Gene

miRNA

Aliases for MIR643 Gene

External Ids for MIR643 Gene

Previous HGNC Symbols for MIR643 Gene

  • MIRN643

Previous GeneCards Identifiers for MIR643 Gene

  • GC19P057478
  • GC19P052785

Summaries for MIR643 Gene

Entrez Gene Summary for MIR643 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR643 Gene

MIR643 (MicroRNA 643) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR643 include Endometritis.

Rfam classification for MIR643 Gene

Additional gene information for MIR643 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR643 Gene

Genomics for MIR643 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR643 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052276 Enhancer 0.2 Ensembl 0.4 -5.1 -5096 0.2 HSALNG0127306 MIR643 ZNF766 ZNF480
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR643 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR643 Gene

Latest Assembly
chr19:52,281,797-52,281,893
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand

Previous Assembly
chr19:52,785,050-52,785,146
(GRCh37/hg19 by Entrez Gene)
Size:
97 bases
Orientation:
Plus strand

chr19:52,785,050-52,785,146
(GRCh37/hg19 by Ensembl)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR643 Gene

Genes around MIR643 on UCSC Golden Path with GeneCards custom track
MIR643 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR643 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR643 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR643 Gene

Proteins for MIR643 Gene

Post-translational modifications for MIR643 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR643 Gene

Domains & Families for MIR643 Gene

Gene Families for MIR643 Gene

HGNC:
genes like me logo Genes that share domains with MIR643: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR643 Gene

Function for MIR643 Gene

Phenotypes From GWAS Catalog for MIR643 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR643 Gene

Localization for MIR643 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR643 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR643 Gene

Pathways & Interactions for MIR643 Gene

PathCards logo

SuperPathways for MIR643 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR643 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR643: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR643 Gene

Drugs & Compounds for MIR643 Gene

No Compound Related Data Available

Transcripts for MIR643 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR643 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006D5889_9606 pre_miRNA 97 5

RefSeq: NR_030373,

Ensembl: ENST00000385267 (view in UCSC) ,

miRBase: MI0003658,

Rfam: RF00980,

ENA: LM609586.1:1..97:precursor_RNA,

URS00001941B8_9606 miRNA 22 5

RefSeq: NR_030373,

LncBase: hsa-miR-643,

miRBase: MIMAT0003313,

TarBase: hsa-miR-643,

ENA: LM379884.1:1..22:ncRNA, LM609586.1:61..82:ncRNA,

URS0001BC6684_9606 pre_miRNA 94 1

Rfam: RF00980,

MIR643 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR643 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR643 Gene

No ASD Table

Relevant External Links for MIR643 Gene

GeneLoc Exon Structure for
MIR643

Expression for MIR643 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR643 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR643

genes like me logo Genes that share expression patterns with MIR643: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR643 Gene

Orthologs for MIR643 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR643 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-643 31
  • 98 (a)
OneToOne
Species where no ortholog for MIR643 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR643 Gene

ENSEMBL:
Gene Tree for MIR643 (if available)
TreeFam:
Gene Tree for MIR643 (if available)

Paralogs for MIR643 Gene

No data available for Paralogs for MIR643 Gene

Variants for MIR643 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR643 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR643 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259
nsv960862 CNV duplication 23825009

Additional Variant Information for MIR643 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR643

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR643 Gene

Disorders for MIR643 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR643 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
endometritis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR643

genes like me logo Genes that share disorders with MIR643: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR643 Gene

Publications for MIR643 Gene

  1. MiR-643 inhibits lipopolysaccharide-induced endometritis progression by targeting TRAF6. (PMID: 31930635) Zhao R … Chen Y (Cell biology international 2020) 3
  2. Entamoeba histolytica Up-Regulates MicroRNA-643 to Promote Apoptosis by Targeting XIAP in Human Epithelial Colon Cells. (PMID: 30671387) López-Rosas I … Marchat LA (Frontiers in cellular and infection microbiology 2018) 3
  3. MicroRNA‑643 regulates the expression of ZEB1 and inhibits tumorigenesis in osteosarcoma. (PMID: 28849077) Wang H … Peng Z (Molecular medicine reports 2017) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR643 Gene

Sources for MIR643 Gene