microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR642B Gene

Subcategory (RNA class) for MIR642B Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR642B Gene

  • MicroRNA 642b 2 3 5
  • Hsa-MiR-642b-3p 163 173
  • Hsa-MiR-642b-5p 163 173
  • Hsa-Mir-642b 2 3
  • MIR642B 2 5
  • Hsa-Mir-642-As 178
  • MIMAT0022736 50
  • MIMAT0018444 50
  • MI0016685 50
  • Mir-642b 3

External Ids for MIR642B Gene

Previous GeneCards Identifiers for MIR642B Gene

  • GC19U901469
  • GC19M046181

Summaries for MIR642B Gene

Entrez Gene Summary for MIR642B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR642B Gene

MIR642B (MicroRNA 642b) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR642B Gene

Additional gene information for MIR642B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR642B Gene

Genomics for MIR642B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR642B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045676 Promoter/Enhancer 1.1 Ensembl ENCODE 0.7 -2.5 -2492 2.6 SP1 TEAD4 PRDM10 KDM1A CTCF BACH1 ZNF143 PKNOX1 EZH2 PBX2 CCDC61 CLASRP SYMPK FBXO46 SNRPD2 ENSG00000268810 ENSG00000269148 GIPR PNMA8A MIR642B
GH19J045680 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 0.4 -6.6 -6639 1.5 HNRNPL CTCF ZBTB33 PRDM10 ZNF692 BACH1 JUND FOXA1 LARP7 ZNF143 RF00017-3013 SNRPD2 IGFL4 MIR642B GIPR QPCTL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR642B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR642B Gene

Genomic Locations for MIR642B Gene
chr19:45,674,932-45,675,008
(GRCh38/hg38)
Size:
77 bases
Orientation:
Minus strand
chr19:46,178,190-46,178,266
(GRCh37/hg19)
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR642B Gene

Genes around MIR642B on UCSC Golden Path with GeneCards custom track
MIR642B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR642B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR642B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR642B Gene

Proteins for MIR642B Gene

Post-translational modifications for MIR642B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR642B Gene

Domains & Families for MIR642B Gene

Gene Families for MIR642B Gene

HGNC:
genes like me logo Genes that share domains with MIR642B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR642B Gene

Function for MIR642B Gene

Phenotypes From GWAS Catalog for MIR642B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR642B Gene

Localization for MIR642B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR642B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR642B Gene

Pathways & Interactions for MIR642B Gene

PathCards logo

SuperPathways for MIR642B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR642B Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR642B Gene

Drugs & Compounds for MIR642B Gene

No Compound Related Data Available

Transcripts for MIR642B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR642B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000453664_9606 miRNA 22 6

RefSeq: NR_037512,

LncBase: hsa-miR-642b-3p,

miRBase: MIMAT0018444,

MirGeneDB: Hsa-Mir-642-as_3p,

TarBase: hsa-miR-642b-3p,

ENA: LM382185.1:1..22:ncRNA, LM611268.1:47..68:ncRNA,

URS000075E432_9606 precursor_RNA 77 5

HGNC: 38902,

RefSeq: NR_037512,

Ensembl: ENST00000637346 (view in UCSC) ,

miRBase: MI0016685,

ENA: LM611268.1:1..77:precursor_RNA,

URS000075B1CE_9606 miRNA 22 5

RefSeq: NR_037512,

LncBase: hsa-miR-642b-5p,

miRBase: MIMAT0022736,

TarBase: hsa-miR-642b-5p,

ENA: LM611268.1:10..31:ncRNA,

URS0000EFDF88_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-642-as,

URS0000EFC6FB_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-642-as_5p,

MIR642B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR642B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR642B Gene

No ASD Table

Relevant External Links for MIR642B Gene

GeneLoc Exon Structure for
MIR642B

Expression for MIR642B Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR642B Gene

Orthologs for MIR642B Gene

Evolution for MIR642B Gene

ENSEMBL:
Gene Tree for MIR642B (if available)
TreeFam:
Gene Tree for MIR642B (if available)

No data available for Orthologs for MIR642B Gene

Paralogs for MIR642B Gene

No data available for Paralogs for MIR642B Gene

Variants for MIR642B Gene

Additional dbSNP identifiers (rs#s) for MIR642B Gene

Additional Variant Information for MIR642B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR642B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR642B Gene

Disorders for MIR642B Gene

Additional Disease Information for MIR642B

No disorders were found for MIR642B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR642B Gene

Publications for MIR642B Gene

  1. PRRX1 Regulates Cellular Phenotype Plasticity and Dormancy of Head and Neck Squamous Cell Carcinoma Through miR-642b-3p. (PMID: 30622052) Jiang J … Liang XH (Neoplasia (New York, N.Y.) 2019) 3
  2. MicroRNA expression profiling in Guillain-Barré syndrome. (PMID: 27836180) Lv Z … Wang Y (Journal of neuroimmunology 2016) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D … Lui WO (BMC biology 2010) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR642B Gene

Sources for MIR642B Gene