microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR642A Gene

Subcategory (RNA class) for MIR642A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR642A Gene

  • MicroRNA 642a 2 3 5
  • Hsa-Mir-642 2 3 178
  • Hsa-MiR-642a-5p 163 173
  • MicroRNA 642 2 3
  • MIR642A 2 5
  • MicroRNA Mir-642a 3
  • Hsa-MiR-642a-3p 173
  • Hsa-Mir-642a 3
  • MIMAT0020924 50
  • MIMAT0003312 50
  • MI0003657 50
  • Mir-642a 3
  • MIRN642 3
  • RF00963 168
  • MIR642 3

External Ids for MIR642A Gene

Previous HGNC Symbols for MIR642A Gene

  • MIRN642
  • MIR642

Previous GeneCards Identifiers for MIR642A Gene

  • GC19P046179

Summaries for MIR642A Gene

Entrez Gene Summary for MIR642A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR642A Gene

MIR642A (MicroRNA 642a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR642A include Leiomyoma, Uterine and Central Nervous System Tuberculosis.

Rfam classification for MIR642A Gene

Additional gene information for MIR642A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR642A Gene

Genomics for MIR642A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR642A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045568 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 -105.9 -105917 2.8 CTCF ZBTB33 PRDM10 ZNF629 KDM1A ZNF143 ZIC2 RXRB PATZ1 REST CCDC61 SYMPK OPA3 CLASRP BLOC1S3 VASP ENSG00000269148 FBXO46 RTN2 PPM1N
GH19J045706 Enhancer 1 Ensembl ENCODE 12 +32.0 31993 1.8 SP1 ZNF143 RELA TCF12 IKZF2 TRIM22 POLR2A PKNOX1 EED ZBTB20 FBXO46 MIR642A MEIOSIN FOXA3 SYMPK DMWD PNMA8A piR-51337 RF00017-3014 SNRPD2
GH19J045571 Enhancer 0.3 Ensembl dbSUPER 11.4 -103.4 -103427 0.6 VASP RTN2 PPM1N EML2 MIR330 MIR642A ERCC1 POLR1G PPP1R13L OPA3
GH19J045570 Enhancer 0.3 Ensembl 11.4 -104.1 -104127 0.4 ZNF121 VASP RTN2 PPM1N EML2 MIR330 MIR642A ERCC1 POLR1G PPP1R13L OPA3
GH19J045667 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.4 -5.8 -5827 5.4 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF512 RFX1 LEF1 IKZF1 GIPR CCDC61 CLASRP SNRPD2 ENSG00000269148 FBXO46 ENSG00000268810 DM1-AS ENSG00000259605 IRF2BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR642A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR642A Gene

Genomic Locations for MIR642A Gene
chr19:45,674,928-45,675,024
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr19:46,178,186-46,178,282
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR642A Gene

Genes around MIR642A on UCSC Golden Path with GeneCards custom track
MIR642A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR642A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR642A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR642A Gene

Proteins for MIR642A Gene

Post-translational modifications for MIR642A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR642A Gene

Domains & Families for MIR642A Gene

Gene Families for MIR642A Gene

HGNC:
genes like me logo Genes that share domains with MIR642A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR642A Gene

Function for MIR642A Gene

Phenotypes From GWAS Catalog for MIR642A Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR642A Gene

Localization for MIR642A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR642A gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR642A Gene

Pathways & Interactions for MIR642A Gene

PathCards logo

SuperPathways for MIR642A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR642A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR642A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR642A Gene

Drugs & Compounds for MIR642A Gene

No Compound Related Data Available

Transcripts for MIR642A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR642A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000069A81A_9606 precursor_RNA 97 6

HGNC: 32898,

RefSeq: NR_030372,

Ensembl: ENST00000385039 (view in UCSC) ,

miRBase: MI0003657,

Rfam: RF00963,

ENA: LM609585.1:1..97:precursor_RNA,

URS00000F2C33_9606 miRNA 22 6

RefSeq: NR_030372,

LncBase: hsa-miR-642a-5p,

miRBase: MIMAT0003312,

MirGeneDB: Hsa-Mir-642_5p,

TarBase: hsa-miR-642a-5p,

ENA: LM379883.1:1..22:ncRNA, LM609585.1:16..37:ncRNA,

URS00000E7139_9606 miRNA 22 5

RefSeq: NR_030372,

miRBase: MIMAT0020924,

MirGeneDB: Hsa-Mir-642_3p,

TarBase: hsa-miR-642a-3p,

ENA: LM382871.1:1..22:ncRNA, LM609585.1:51..72:ncRNA,

URS0000EFCC98_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-642,

MIR642A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR642A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR642A Gene

No ASD Table

Relevant External Links for MIR642A Gene

GeneLoc Exon Structure for
MIR642A

Expression for MIR642A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR642A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR642A

genes like me logo Genes that share expression patterns with MIR642A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR642A Gene

Orthologs for MIR642A Gene

Evolution for MIR642A Gene

ENSEMBL:
Gene Tree for MIR642A (if available)
TreeFam:
Gene Tree for MIR642A (if available)

No data available for Orthologs for MIR642A Gene

Paralogs for MIR642A Gene

No data available for Paralogs for MIR642A Gene

Variants for MIR642A Gene

Additional dbSNP identifiers (rs#s) for MIR642A Gene

Additional Variant Information for MIR642A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR642A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR642A Gene

Disorders for MIR642A Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR642A Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR642A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR642A Gene

Publications for MIR642A Gene

  1. Plasma microRNA Profile Differentiates Crohn's Colitis From Ulcerative Colitis. (PMID: 29272478) Netz U … Galandiuk S (Inflammatory bowel diseases 2017) 3
  2. A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. (PMID: 25476897) Tang J … Sun B (Cell death & disease 2014) 3
  3. A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis. (PMID: 23697367) Vecchione A … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. (PMID: 21767385) Zaragosi LE … Barbry P (Genome biology 2011) 3

Products for MIR642A Gene

Sources for MIR642A Gene