microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR641 Gene

Subcategory (RNA class) for MIR641 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR641 Gene

  • MicroRNA 641 2 3 5
  • Hsa-MiR-641 168 179
  • MIMAT0003311 53
  • Hsa-Mir-641 3
  • MI0003656 53
  • Mir-641 3
  • MIRN641 3
  • MIR641 2

External Ids for MIR641 Gene

Previous HGNC Symbols for MIR641 Gene

  • MIRN641

Previous GeneCards Identifiers for MIR641 Gene

  • GC19M045481
  • GC19M040788

Summaries for MIR641 Gene

Entrez Gene Summary for MIR641 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR641 Gene

MIR641 (MicroRNA 641) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR641 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR641 Gene

Genomics for MIR641 Gene

GeneHancer (GH) Regulatory Elements for MIR641 Gene

Promoters and enhancers for MIR641 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040277 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.1 64 10.4 ZNF785 SIN3A SP1 ZBTB40 SREBF1 SIX5 ZBTB6 FOXA1 RBPJ POLR2A AKT2 MIR641 lnc-C19orf47-3 ZNF780B NUMBL HNRNPUL1 ZNF780A SNRPA MAP3K10 ENSG00000269843
GH19J041217 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.9 -940.3 -940307 10.7 ZNF785 SIN3A ZBTB40 ZBTB6 RBPJ SMARCE1 POLR2A USF2 NR2F6 RUNX1 AXL ENSG00000269652 ZNF574 ZNF526 SNRPA HNRNPUL1 ENSG00000269843 ITPKC SERTAD3 CCDC97
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR641 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR641 Gene

Genomic Locations for MIR641 Gene
chr19:40,282,543-40,282,641
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand
chr19:40,788,450-40,788,548
(GRCh37/hg19)
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR641 Gene

Genes around MIR641 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR641 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR641 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR641 Gene

Proteins for MIR641 Gene

Post-translational modifications for MIR641 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR641 Gene

Domains & Families for MIR641 Gene

Gene Families for MIR641 Gene

HGNC:
genes like me logo Genes that share domains with MIR641: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR641 Gene

Function for MIR641 Gene

Phenotypes From GWAS Catalog for MIR641 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR641 Gene

Localization for MIR641 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR641 Gene

Pathways & Interactions for MIR641 Gene

PathCards logo

SuperPathways for MIR641 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR641 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR641 Gene

Drugs & Compounds for MIR641 Gene

No Compound Related Data Available

Transcripts for MIR641 Gene

mRNA/cDNA for MIR641 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(3) ENA transcripts :
(2) miRBase transcripts :
(1) TarBase transcripts :
(1) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR641 Gene

No ASD Table

Relevant External Links for MIR641 Gene

GeneLoc Exon Structure for
MIR641
ECgene alternative splicing isoforms for
MIR641

Expression for MIR641 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR641 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR641 Gene:

MIR641
genes like me logo Genes that share expression patterns with MIR641: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR641 Gene

Orthologs for MIR641 Gene

Evolution for MIR641 Gene

ENSEMBL:
Gene Tree for MIR641 (if available)
TreeFam:
Gene Tree for MIR641 (if available)

No data available for Orthologs for MIR641 Gene

Paralogs for MIR641 Gene

No data available for Paralogs for MIR641 Gene

Variants for MIR641 Gene

Sequence variations from dbSNP and Humsavar for MIR641 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000296868 -- 40,283,429(-) G/A upstream_transcript_variant
rs1001972179 -- 40,282,247(-) C/T downstream_transcript_variant
rs1002141057 -- 40,283,815(-) CCCCTTGGCC/C upstream_transcript_variant
rs1002431461 -- 40,284,103(-) T/C upstream_transcript_variant
rs1005987359 -- 40,284,374(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR641 Gene

Variant ID Type Subtype PubMed ID
esv1005660 CNV deletion 20482838
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372
nsv1057052 CNV loss 25217958
nsv1160618 CNV deletion 26073780

Additional Variant Information for MIR641 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR641

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR641 Gene

Disorders for MIR641 Gene

Additional Disease Information for MIR641

No disorders were found for MIR641 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR641 Gene

Publications for MIR641 Gene

  1. miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer. (PMID: 28800790) Kong Q … Xu N (Oncology research 2018) 3 56
  2. Increased expression of miR-641 contributes to erlotinib resistance in non-small-cell lung cancer cells by targeting NF1. (PMID: 29493886) Chen J … Li Q (Cancer medicine 2018) 3 56
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 56
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56
  5. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 56

Products for MIR641 Gene

Sources for MIR641 Gene