microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR641 Gene

Data sources for MIR641 Gene:

Subcategory (RNA class) for MIR641 Gene

miRNA

Aliases for MIR641 Gene

External Ids for MIR641 Gene

Previous HGNC Symbols for MIR641 Gene

  • MIRN641

Previous GeneCards Identifiers for MIR641 Gene

  • GC19M045481
  • GC19M040788

Summaries for MIR641 Gene

Entrez Gene Summary for MIR641 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR641 Gene

MIR641 (MicroRNA 641) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR641 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR641 Gene

Genomics for MIR641 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR641 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040277 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.1 64 10.4 ZSCAN16 TBP SP1 ZBTB10 MXD4 SIX5 SMAD5 MBD2 POLR2A BHLHE40 AKT2 HSALNG0126085 MIR641 lnc-C19orf47-3 ZNF780B NUMBL SUPT5H COQ8B SNRPA ZNF780A
GH19J041217 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.9 -940.3 -940307 10.7 ZBTB10 MNT IKZF1 HES1 MBD2 BHLHE40 ZEB1 NONO ZIC2 CEBPB AXL ENSG00000269652 ZNF574 ZNF526 SNRPA ENSG00000269843 HNRNPUL1 CCDC97 ENSG00000268366 SERTAD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR641 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR641 Gene

Latest Assembly
chr19:40,282,543-40,282,641
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand

Previous Assembly
chr19:40,788,450-40,788,548
(GRCh37/hg19 by Entrez Gene)
Size:
99 bases
Orientation:
Minus strand

chr19:40,788,450-40,788,548
(GRCh37/hg19 by Ensembl)
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR641 Gene

Genes around MIR641 on UCSC Golden Path with GeneCards custom track
MIR641 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR641 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR641 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR641 Gene

Proteins for MIR641 Gene

Post-translational modifications for MIR641 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR641 Gene

Domains & Families for MIR641 Gene

Gene Families for MIR641 Gene

HGNC:
genes like me logo Genes that share domains with MIR641: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR641 Gene

Function for MIR641 Gene

Phenotypes From GWAS Catalog for MIR641 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR641 Gene

Localization for MIR641 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR641 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR641 Gene

Pathways & Interactions for MIR641 Gene

PathCards logo

SuperPathways for MIR641 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR641 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR641 Gene

Drugs & Compounds for MIR641 Gene

No Compound Related Data Available

Transcripts for MIR641 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR641 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000039D790_9606 miRNA 24 5

RefSeq: NR_030371,

LncBase: hsa-miR-641,

miRBase: MIMAT0003311,

TarBase: hsa-miR-641,

ENA: LM379882.1:1..24:ncRNA, LM609584.1:16..39:ncRNA,

URS000075CBEE_9606 precursor_RNA 99 4

RefSeq: NR_030371,

Ensembl: ENST00000384899 (view in UCSC) ,

miRBase: MI0003656,

ENA: LM609584.1:1..99:precursor_RNA,

MIR641 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR641 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR641 Gene

No ASD Table

Relevant External Links for MIR641 Gene

GeneLoc Exon Structure for
MIR641

Expression for MIR641 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR641 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR641

genes like me logo Genes that share expression patterns with MIR641: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR641 Gene

Orthologs for MIR641 Gene

Evolution for MIR641 Gene

ENSEMBL:
Gene Tree for MIR641 (if available)
TreeFam:
Gene Tree for MIR641 (if available)

No data available for Orthologs for MIR641 Gene

Paralogs for MIR641 Gene

No data available for Paralogs for MIR641 Gene

Variants for MIR641 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR641 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR641 Gene

Variant ID Type Subtype PubMed ID
esv1005660 CNV deletion 20482838
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372
nsv1057052 CNV loss 25217958
nsv1160618 CNV deletion 26073780

Additional Variant Information for MIR641 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR641

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR641 Gene

Disorders for MIR641 Gene

Additional Disease Information for MIR641

No disorders were found for MIR641 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR641 Gene

Publications for MIR641 Gene

  1. Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma. (PMID: 32423991) Li D … Dang X (Molecular and cellular biology 2020) 3
  2. lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) Promotes Proliferation and Inhibits Apoptosis in Non-Small Cell Lung Cancer Cells by Regulating the miR-641/CDK6 Axis. (PMID: 30982057) Fan YF … Cui XY (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  3. LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR-641/PTEN axis. (PMID: 31033083) Zhu Y … Wang L (Cell biology international 2019) 3
  4. Long non-coding RNA OIP5-AS1 promotes proliferation of gastric cancer cells by targeting miR-641. (PMID: 31858545) Wang LW … Yue L (European review for medical and pharmacological sciences 2019) 3
  5. miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer. (PMID: 28800790) Kong Q … Xu N (Oncology research 2018) 3

Products for MIR641 Gene

Sources for MIR641 Gene