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Aliases for MIR640 Gene

Subcategory (RNA class) for MIR640 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR640 Gene

  • MicroRNA 640 2 3 5
  • Hsa-Mir-640 3
  • MIRN640 3

External Ids for MIR640 Gene

ORGUL Members for MIR640 Gene

Previous HGNC Symbols for MIR640 Gene

  • MIRN640

Previous GeneCards Identifiers for MIR640 Gene

  • GC19P019407
  • GC19P019545

Summaries for MIR640 Gene

Entrez Gene Summary for MIR640 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR640 Gene

MIR640 (MicroRNA 640) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR640 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR640 Gene

Genomics for MIR640 Gene

GeneHancer (GH) Regulatory Elements for MIR640 Gene

Promoters and enhancers for MIR640 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I019434 Enhancer 0.8 ENCODE dbSUPER 550.8 -0.2 -246 1 FOXA2 RXRA MAX NR2F2 GABPA YY1 JUND HNF4A GC19P019700 GC19P019843 MIR640 NDUFA13 GATAD2A ENSG00000267234
GH19I019432 Enhancer 0.3 dbSUPER 550.8 -2.0 -1957 0.9 ZNF449 GC19P019700 MIR640 LPAR2 ENSG00000267234 GATAD2A
GH19I019435 Enhancer 0.3 dbSUPER 550.8 +1.3 1314 1.5 HNF4A GC19P019700 GC19P019843 MIR640 PIR48619 GATAD2A
GH19I019384 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.9 -47.7 -47719 5.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZBTB7B IRF4 YY1 POLR2B E2F8 GATAD2A NDUFA13 MIR640 UPF1 ELL ENSG00000267234
GH19I019456 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +26.2 26202 9.5 HDGF PKNOX1 SIN3A IRF4 GLIS2 ZNF143 KLF7 FOS SP5 JUNB GATAD2A NDUFA13 GMIP MIR640 MAU2 TM6SF2 RFXANK PBX4 ZNF14 ZNF506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR640 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR640 Gene

Genomic Locations for MIR640 Gene
chr19:19,435,063-19,435,158
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr19:19,545,872-19,545,967
(GRCh37/hg19)

Genomic View for MIR640 Gene

Genes around MIR640 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR640 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR640 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR640 Gene

Proteins for MIR640 Gene

Post-translational modifications for MIR640 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR640 Gene

Domains & Families for MIR640 Gene

Gene Families for MIR640 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR640: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR640 Gene

Function for MIR640 Gene

Phenotypes From GWAS Catalog for MIR640 Gene

Gene Ontology (GO) - Molecular Function for MIR640 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26879375
genes like me logo Genes that share ontologies with MIR640: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR640 Gene

Localization for MIR640 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR640 Gene

Pathways & Interactions for MIR640 Gene

SuperPathways for MIR640 Gene

No Data Available

Interacting Proteins for MIR640 Gene

Gene Ontology (GO) - Biological Process for MIR640 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 26879375
GO:0016525 negative regulation of angiogenesis IDA 26879375
GO:0035195 gene silencing by miRNA IDA 26879375
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 26879375
genes like me logo Genes that share ontologies with MIR640: view

No data available for Pathways by source and SIGNOR curated interactions for MIR640 Gene

Drugs & Compounds for MIR640 Gene

No Compound Related Data Available

Transcripts for MIR640 Gene

mRNA/cDNA for MIR640 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR640 Gene

No ASD Table

Relevant External Links for MIR640 Gene

GeneLoc Exon Structure for
MIR640
ECgene alternative splicing isoforms for
MIR640

Expression for MIR640 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR640 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR640 Gene:

MIR640
genes like me logo Genes that share expression patterns with MIR640: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR640 Gene

Orthologs for MIR640 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR640 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-640 34
  • 99 (a)
OneToOne
Species where no ortholog for MIR640 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR640 Gene

ENSEMBL:
Gene Tree for MIR640 (if available)
TreeFam:
Gene Tree for MIR640 (if available)

Paralogs for MIR640 Gene

No data available for Paralogs for MIR640 Gene

Variants for MIR640 Gene

Sequence variations from dbSNP and Humsavar for MIR640 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000281064 -- 19,434,076(+) T/C upstream_transcript_variant
rs1003404321 -- 19,435,148(+) T/G non_coding_transcript_variant
rs1004377078 -- 19,435,640(+) A/G downstream_transcript_variant
rs1004935584 -- 19,433,266(+) A/G upstream_transcript_variant
rs1004963053 -- 19,434,272(+) C/G upstream_transcript_variant

Additional Variant Information for MIR640 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR640

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR640 Gene

Disorders for MIR640 Gene

Additional Disease Information for MIR640

No disorders were found for MIR640 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR640 Gene

Publications for MIR640 Gene

  1. Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. (PMID: 26879375) Zhou Y … Zhu YC (American journal of physiology. Cell physiology 2016) 3 58
  2. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 58
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR640 Gene

Sources for MIR640 Gene

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