microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR639 Gene

Subcategory (RNA class) for MIR639 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR639 Gene

  • MicroRNA 639 2 3 5
  • Hsa-Mir-639 2 3
  • MIR639 2 5
  • MIMAT0003309 50
  • Hsa-MiR-639 173
  • MI0003654 50
  • MIRN639 3
  • RF01031 168

External Ids for MIR639 Gene

Previous HGNC Symbols for MIR639 Gene

  • MIRN639

Previous GeneCards Identifiers for MIR639 Gene

  • GC19P014503
  • GC19P014640

Summaries for MIR639 Gene

Entrez Gene Summary for MIR639 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR639 Gene

MIR639 (MicroRNA 639) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR639 include Epithelioid Cell Melanoma. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis.

Rfam classification for MIR639 Gene

Additional gene information for MIR639 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR639 Gene

Genomics for MIR639 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR639 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014525 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.4 -1352 5.9 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 RFX1 IKZF1 POLR2A RCOR2 TECR MIR639 piR-33843 lnc-GIPC1-1 CCDC130 AKAP8 MRI1 BRD4 ZNF333 DNAJB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR639 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR639 Gene

Genomic Locations for MIR639 Gene
chr19:14,529,543-14,529,640
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr19:14,640,355-14,640,452
(GRCh37/hg19)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR639 Gene

Genes around MIR639 on UCSC Golden Path with GeneCards custom track
MIR639 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR639 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR639 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR639 Gene

Proteins for MIR639 Gene

Post-translational modifications for MIR639 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR639 Gene

Domains & Families for MIR639 Gene

Gene Families for MIR639 Gene

HGNC:
genes like me logo Genes that share domains with MIR639: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR639 Gene

Function for MIR639 Gene

Gene Ontology (GO) - Molecular Function for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR639: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR639 Gene

Localization for MIR639 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR639 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR639 Gene

Pathways & Interactions for MIR639 Gene

genes like me logo Genes that share pathways with MIR639: view

Gene Ontology (GO) - Biological Process for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA, IEA --
genes like me logo Genes that share ontologies with MIR639: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR639 Gene

Drugs & Compounds for MIR639 Gene

No Compound Related Data Available

Transcripts for MIR639 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR639 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006BE831_9606 precursor_RNA 98 5

HGNC: 32895,

RefSeq: NR_030369,

Ensembl: ENST00000384974 (view in UCSC) ,

miRBase: MI0003654,

Rfam: RF01031,

URS000075B8B8_9606 miRNA 23 3

RefSeq: NR_030369,

miRBase: MIMAT0003309,

TarBase: hsa-miR-639,

MIR639 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR639 Gene

No ASD Table

Relevant External Links for MIR639 Gene

GeneLoc Exon Structure for
MIR639

No data available for mRNA/cDNA for MIR639 Gene

Expression for MIR639 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR639 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR639

genes like me logo Genes that share expression patterns with MIR639: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR639 Gene

Orthologs for MIR639 Gene

Evolution for MIR639 Gene

ENSEMBL:
Gene Tree for MIR639 (if available)
TreeFam:
Gene Tree for MIR639 (if available)

No data available for Orthologs for MIR639 Gene

Paralogs for MIR639 Gene

No data available for Paralogs for MIR639 Gene

Variants for MIR639 Gene

Additional dbSNP identifiers (rs#s) for MIR639 Gene

Additional Variant Information for MIR639 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR639

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR639 Gene

Disorders for MIR639 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR639 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epithelioid cell melanoma
  • epithelioid melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR639

genes like me logo Genes that share disorders with MIR639: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR639 Gene

Publications for MIR639 Gene

  1. MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression. (PMID: 27829546) Lei ST … Xu B (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3
  2. miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1. (PMID: 25130698) Lin Z … Li J (Cancer science 2014) 3
  3. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR639 Gene

Sources for MIR639 Gene