microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR638 Gene

Subcategory (RNA class) for MIR638 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR638 Gene

  • MicroRNA 638 2 3 5
  • Hsa-Mir-638 2 3
  • Hsa-MiR-638 163 173
  • MIR638 2 5
  • MIMAT0003308 50
  • MI0003653 50
  • MIRN638 3
  • RF00978 168

External Ids for MIR638 Gene

Previous HGNC Symbols for MIR638 Gene

  • MIRN638

Previous GeneCards Identifiers for MIR638 Gene

  • GC19U901002
  • GC19P010692
  • GC19P010829

Summaries for MIR638 Gene

Entrez Gene Summary for MIR638 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR638 Gene

MIR638 (MicroRNA 638) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR638 include Systemic Lupus Erythematosus and Charcot-Marie-Tooth Disease, Dominant Intermediate B.

Rfam classification for MIR638 Gene

Additional gene information for MIR638 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR638 Gene

Genomics for MIR638 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR638 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010717 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.5 470 4.3 SP1 CREB1 GATAD2A CTCF PRDM10 REST ZNF512 RFX1 SIX5 LEF1 DNM2 MIR638 EIF3G ILF3 KRI1 FBXL12 RAVER1 UBE2L4 QTRT1 ZNF627
GH19J010758 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12 +44.8 44757 8.9 SP1 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 RFX1 NFKBIZ ZNF692 RCOR2 KRI1 FBXL12 ILF3 RAVER1 ZNF823 PPAN MIR199A1 SLC44A2 MIR638 DNM2
GH19J010759 Promoter/Enhancer 0.9 Ensembl dbSUPER 12 +40.0 39997 0.4 ZNF512 IKZF1 ZNF444 TRIM24 PCBP1 WT1 ZNF366 ZNF398 MLLT1 MIR199A1 MIR638 DNM2 lnc-QTRT1-3 piR-53141 TMED1 lnc-TIMM29-1
GH19J010757 Enhancer 0.6 ENCODE dbSUPER 12 +39.8 39757 0 ZNF512 IKZF1 PCBP1 ZNF366 ZNF398 MIR199A1 MIR638 DNM2 lnc-QTRT1-3 piR-53141 TMED1 lnc-TIMM29-1
GH19J010724 Enhancer 0.5 ENCODE dbSUPER 0.4 +6.4 6447 0.8 CTCF GATA2 piR-53141 SLC44A2 ILF3-DT SMARCA4 DNM2 MIR638 TMED1 lnc-TIMM29-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR638 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR638 Gene

Genomic Locations for MIR638 Gene
chr19:10,718,404-10,718,503
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr19:10,829,080-10,829,179
(GRCh37/hg19)
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR638 Gene

Genes around MIR638 on UCSC Golden Path with GeneCards custom track
MIR638 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR638 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR638 Gene

Proteins for MIR638 Gene

Post-translational modifications for MIR638 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR638 Gene

Domains & Families for MIR638 Gene

Gene Families for MIR638 Gene

HGNC:
genes like me logo Genes that share domains with MIR638: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR638 Gene

Function for MIR638 Gene

Phenotypes From GWAS Catalog for MIR638 Gene

Gene Ontology (GO) - Molecular Function for MIR638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23554459
genes like me logo Genes that share ontologies with MIR638: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR638 Gene

Localization for MIR638 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR638 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23554459
genes like me logo Genes that share ontologies with MIR638: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR638 Gene

Pathways & Interactions for MIR638 Gene

PathCards logo

SuperPathways for MIR638 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA, IEA --
GO:0048008 platelet-derived growth factor receptor signaling pathway IDA 23554459
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IDA 23554459
GO:1904753 negative regulation of vascular associated smooth muscle cell migration IDA 23554459
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA 23554459
genes like me logo Genes that share ontologies with MIR638: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR638 Gene

Drugs & Compounds for MIR638 Gene

No Compound Related Data Available

Transcripts for MIR638 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR638 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000668846_9606 precursor_RNA 100 5

HGNC: 32894,

RefSeq: NR_030368,

Ensembl: ENST00000385237 (view in UCSC) ,

miRBase: MI0003653,

Rfam: RF00978,

URS000075DB2F_9606 miRNA 25 4

RefSeq: NR_030368,

LncBase: hsa-miR-638,

miRBase: MIMAT0003308,

TarBase: hsa-miR-638,

MIR638 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR638 Gene

No ASD Table

Relevant External Links for MIR638 Gene

GeneLoc Exon Structure for
MIR638

No data available for mRNA/cDNA for MIR638 Gene

Expression for MIR638 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR638 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR638

genes like me logo Genes that share expression patterns with MIR638: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR638 Gene

Orthologs for MIR638 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR638 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
OneToOne
Species where no ortholog for MIR638 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR638 Gene

ENSEMBL:
Gene Tree for MIR638 (if available)
TreeFam:
Gene Tree for MIR638 (if available)

Paralogs for MIR638 Gene

No data available for Paralogs for MIR638 Gene

Variants for MIR638 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR638 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
703760 Likely Benign: Charcot-Marie-Tooth disease, dominant intermediate B 10,718,407(+) A/AGCGGGCGCGGCAG NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs1555696272 Uncertain Significance: Charcot-Marie-Tooth disease, dominant intermediate B 10,718,406(+) G/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR638 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR638 Gene

Variant ID Type Subtype PubMed ID
nsv1061882 CNV gain 25217958
nsv1160584 CNV deletion 26073780
nsv1160585 CNV deletion 26073780
nsv833745 CNV loss 17160897
nsv833746 CNV loss 17160897

Additional Variant Information for MIR638 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR638

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR638 Gene

Disorders for MIR638 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR638 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR638

genes like me logo Genes that share disorders with MIR638: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR638 Gene

Publications for MIR638 Gene

  1. Hypoxia-Regulated miRNAs in Human Mesenchymal Stem Cells: Exploring the Regulatory Effects in Ischemic Disorders. (PMID: 30884856) Dell'Aversana C … Cobellis G (International journal of molecular sciences 2019) 3
  2. MiR-638 suppresses the progression of oral squamous cell carcinoma through wnt/β-catenin pathway by targeting phospholipase D1. (PMID: 31379206) Tang KL … Xiong SJ (Artificial cells, nanomedicine, and biotechnology 2019) 3
  3. MicroRNA-638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1. (PMID: 30076719) Wang H … Sun J (Journal of cellular physiology 2018) 3
  4. hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. (PMID: 30010402) Chen Z … Duan X (DNA and cell biology 2018) 3
  5. MiR-638 serves as a tumor suppressor by targeting HOXA9 in glioma. (PMID: 30536324) Zheng DH … Xu XB (European review for medical and pharmacological sciences 2018) 3

Products for MIR638 Gene

Sources for MIR638 Gene