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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR638 (MicroRNA 638) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR638 include Systemic Lupus Erythematosus and Charcot-Marie-Tooth Disease, Dominant Intermediate B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23554459 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 23554459 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA, IEA | -- |
GO:0048008 | platelet-derived growth factor receptor signaling pathway | IDA | 23554459 |
GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | IDA | 23554459 |
GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | IDA | 23554459 |
GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | IDA | 23554459 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000668846_9606 | precursor_RNA | 100 | 5 |
HGNC: 32894, RefSeq: NR_030368, Ensembl: ENST00000385237 (view in UCSC) , miRBase: MI0003653, Rfam: RF00978, |
URS000075DB2F_9606 | miRNA | 25 | 4 |
RefSeq: NR_030368, LncBase: hsa-miR-638, miRBase: MIMAT0003308, TarBase: hsa-miR-638, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
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OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
703760 | Likely Benign: Charcot-Marie-Tooth disease, dominant intermediate B | 10,718,407(+) | A/AGCGGGCGCGGCAG | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
rs1555696272 | Uncertain Significance: Charcot-Marie-Tooth disease, dominant intermediate B | 10,718,406(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1061882 | CNV | gain | 25217958 |
nsv1160584 | CNV | deletion | 26073780 |
nsv1160585 | CNV | deletion | 26073780 |
nsv833745 | CNV | loss | 17160897 |
nsv833746 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
systemic lupus erythematosus |
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charcot-marie-tooth disease, dominant intermediate b |
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charcot-marie-tooth disease |
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