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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR638 Gene
Subcategory (RNA class) for MIR638 Gene
miRNA
Number of RNA Genes sources:
4 / 17
Aliases for MIR638 Gene
External Ids for MIR638 Gene
- HGNC: 32894
- Entrez Gene: 693223
- Ensembl: ENSG00000207972
- miRBase: hsa-mir-638
Previous HGNC Symbols for MIR638 Gene
- MIRN638
Previous GeneCards Identifiers for MIR638 Gene
- GC19U901002
- GC19P010692
- GC19P010829
Summaries for MIR638 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR638 Gene
MIR638 (MicroRNA 638) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR638 include Systemic Lupus Erythematosus and Charcot-Marie-Tooth Disease, Dominant Intermediate B.
Rfam classification for MIR638 Gene
-
microRNA mir-638
Additional gene information for MIR638 Gene
- Monarch Initiative
- Search for MIR638 at DataMed
- Search for MIR638 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR638 Gene
Genomics for MIR638 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR638 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR638 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR638 Gene
Genomic Locations for MIR638 Gene
- chr19:10,718,404-10,718,503
- (GRCh38/hg38)
- Size:
- 100 bases
- Orientation:
- Plus strand
- chr19:10,829,080-10,829,179
- (GRCh37/hg19)
- Size:
- 100 bases
- Orientation:
- Plus strand
Genomic View for MIR638 Gene
Genes around MIR638 on UCSC Golden Path with GeneCards custom track
MIR638 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
MIR638 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR638 Gene
Proteins for MIR638 Gene
Post-translational modifications for MIR638 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR638
- Origene Custom Protein Services for MIR638
No data available for DME Specific Peptides for MIR638 Gene
Domains & Families for MIR638 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR638 Gene
Function for MIR638 Gene
Phenotypes From GWAS Catalog for MIR638 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23554459 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR638 - Select products 50% OFF >
- * MIR638 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR638
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR638 - Select products 50% OFF >
- * MIR638 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR638 Gene
Localization for MIR638 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 23554459 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR638 Gene
Pathways & Interactions for MIR638 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA, IEA | -- |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IDA | 23554459 |
| GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | IDA | 23554459 |
| GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | IDA | 23554459 |
| GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | IDA | 23554459 |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR638 Gene
Transcripts for MIR638 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR638 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000668846_9606 | precursor_RNA | 100 | 5 |
HGNC: 32894, RefSeq: NR_030368, Ensembl: ENST00000385237 (view in UCSC) , miRBase: MI0003653, Rfam: RF00978, |
| URS000075DB2F_9606 | miRNA | 25 | 4 |
RefSeq: NR_030368, LncBase: hsa-miR-638, miRBase: MIMAT0003308, TarBase: hsa-miR-638, |
MIR638 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR638 - Select products 50% OFF >
- * MIR638 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR638
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR638 - Select products 50% OFF >
- * MIR638 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR638 Gene
- GeneLoc Exon Structure for
- MIR638
No data available for mRNA/cDNA for MIR638 Gene
Expression for MIR638 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR638
Primer Products
-
OriGene qPCR primer pairs for MIR638
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR638 Gene
Orthologs for MIR638 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToOne |
- Species where no ortholog for MIR638 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for MIR638 Gene
No data available for Paralogs for MIR638 Gene
Variants for MIR638 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR638 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 703760 | Likely Benign: Charcot-Marie-Tooth disease, dominant intermediate B | 10,718,407(+) | A/AGCGGGCGCGGCAG | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
| rs1555696272 | Uncertain Significance: Charcot-Marie-Tooth disease, dominant intermediate B | 10,718,406(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1061882 | CNV | gain | 25217958 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv1160585 | CNV | deletion | 26073780 |
| nsv833745 | CNV | loss | 17160897 |
| nsv833746 | CNV | loss | 17160897 |
Additional Variant Information for MIR638 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR638
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR638 Gene
Disorders for MIR638 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| systemic lupus erythematosus |
|
|
| charcot-marie-tooth disease, dominant intermediate b |
|
|
| charcot-marie-tooth disease |
|
|
Search MIR638 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR638
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR638 Gene
Publications for MIR638 Gene
- Hypoxia-Regulated miRNAs in Human Mesenchymal Stem Cells: Exploring the Regulatory Effects in Ischemic Disorders. (PMID: 30884856) Dell'Aversana C … Cobellis G (International journal of molecular sciences 2019) 3
- MiR-638 suppresses the progression of oral squamous cell carcinoma through wnt/β-catenin pathway by targeting phospholipase D1. (PMID: 31379206) Tang KL … Xiong SJ (Artificial cells, nanomedicine, and biotechnology 2019) 3
- MicroRNA-638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1. (PMID: 30076719) Wang H … Sun J (Journal of cellular physiology 2018) 3
- hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. (PMID: 30010402) Chen Z … Duan X (DNA and cell biology 2018) 3
- MiR-638 serves as a tumor suppressor by targeting HOXA9 in glioma. (PMID: 30536324) Zheng DH … Xu XB (European review for medical and pharmacological sciences 2018) 3
ExternalLinks
Products for MIR638 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR638
- Origene Custom Protein Services for MIR638
- Browse OriGene Inhibitory RNA Products For MIR638
- OriGene qPCR primer pairs for MIR638
- Browse CRISPR knockouts for MIR638
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR638
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR638
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR638
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR638
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR638
Sources for MIR638 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB