Aliases for MIR638 Gene
Subcategory (RNA class) for MIR638 Gene
miRNA
Quality Score for this RNA gene is
13
External Ids for MIR638 Gene
- HGNC: 32894
- Entrez Gene: 693223
- Ensembl: ENSG00000207972
- miRBase: hsa-mir-638
Previous HGNC Symbols for MIR638 Gene
- MIRN638
Previous GeneCards Identifiers for MIR638 Gene
- GC19U901002
- GC19P010829
Summaries for MIR638 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR638 Gene
MIR638 (MicroRNA 638) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR638 include Systemic Lupus Erythematosus and Dnm2-Related Intermediate Charcot-Marie-Tooth Neuropathy.
Additional gene information for MIR638 Gene
- Monarch Initiative
- Search for MIR638 at DataMed
- Search for MIR638 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR638 Gene
Genomics for MIR638 Gene
GeneHancer (GH) Regulatory Elements for MIR638 Gene
Promoters and enhancers for MIR638 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J010717 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 600.7 | +0.6 | 608 | 4 | MTA3 ZFX SP1 CC2D1A CTCF ELF3 SIX5 CBFA2T2 NKRF POLR2A | DNM2 GC19P010718 GC19P010719 MIR638 KRI1 ILF3 EIF3G PPAN FBXL12 TIMM29 | |
| GH19J010758 | Promoter/Enhancer | 1.7 | Ensembl ENCODE dbSUPER | 12 | +44.8 | 44757 | 8.9 | ZNF652 SP1 ELF3 ZKSCAN8 MNT NKRF ZNF121 CEBPG RERE ZNF384 | MIR199A1 SLC44A2 MIR638 DNM2 KRI1 CDKN2D SMARCA4 MIR4748 PIR47140 | |
| GH19J010757 | Enhancer | 0.7 | ENCODE dbSUPER | 12 | +39.8 | 39757 | 0 | IKZF1 ZNF512 ZNF366 ZNF398 | MIR199A1 MIR638 DNM2 MIR4748 PIR47140 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR638 on UCSC Golden Path with GeneCards custom track
Genomic Locations for MIR638 Gene
Genomic Locations for MIR638 Gene
- chr19:10,718,404-10,718,503
- (GRCh38/hg38)
- Size:
- 100 bases
- Orientation:
- Plus strand
- chr19:10,829,080-10,829,179
- (GRCh37/hg19)
- Size:
- 100 bases
- Orientation:
- Plus strand
Genomic View for MIR638 Gene
Genes around MIR638 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
MIR638 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR638 Gene
Proteins for MIR638 Gene
Post-translational modifications for MIR638 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR638
- Origene Custom Protein Services for MIR638
No data available for DME Specific Peptides for MIR638 Gene
Domains & Families for MIR638 Gene
Gene Families for MIR638 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR638 Gene
Function for MIR638 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23554459 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR638
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR638 - Now 50% OFF >
- * MIR638 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR638 CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for MIR638
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR638 - Now 50% OFF >
- * MIR638 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR638 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR638 Gene
Localization for MIR638 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 23554459 |
| GO:0035068 | micro-ribonucleoprotein complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR638 Gene
Pathways & Interactions for MIR638 Gene
Interacting Proteins for MIR638 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IEA | -- |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IDA | 23554459 |
| GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | IDA | 23554459 |
| GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | IDA | 23554459 |
| GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | IDA | 23554459 |
No data available for Pathways by source and SIGNOR curated interactions for MIR638 Gene
Transcripts for MIR638 Gene
mRNA/cDNA for MIR638 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000385237 100 bps (ENST00000385237.1)
- (2) RNA Central transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR638 - Now 50% OFF >
- * MIR638 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR638 CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for MIR638
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR638 - Now 50% OFF >
- * MIR638 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR638 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MIR638 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR638 Gene:
MIR638Primer Products
-
OriGene qPCR primer pairs for MIR638
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR638 Gene
Orthologs for MIR638 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToOne |
- Species where no ortholog for MIR638 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR638 Gene
No data available for Paralogs for MIR638 Gene
Variants for MIR638 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1555696272 | uncertain-significance, DNM2-related intermediate Charcot-Marie-Tooth neuropathy | 10,718,406(+) | G/A | non_coding_transcript_variant | |
| rs534605878 | likely-benign, DNM2-related intermediate Charcot-Marie-Tooth neuropathy | 10,718,323(+) | C/T | upstream_transcript_variant | |
| rs753599004 | uncertain-significance, Centronuclear Myopathy, Dominant, Charcot-Marie-Tooth, Intermediate | 10,718,224(+) | G/A/C/T | upstream_transcript_variant | |
| rs759919549 | likely-benign, DNM2-related intermediate Charcot-Marie-Tooth neuropathy, not specified | 10,718,332(+) | C/T | upstream_transcript_variant | |
| rs774962668 | uncertain-significance, DNM2-related intermediate Charcot-Marie-Tooth neuropathy | 10,718,325(+) | A/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1061882 | CNV | gain | 25217958 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv1160585 | CNV | deletion | 26073780 |
| nsv833745 | CNV | loss | 17160897 |
| nsv833746 | CNV | loss | 17160897 |
Additional Variant Information for MIR638 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR638
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR638 Gene
Disorders for MIR638 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| systemic lupus erythematosus |
|
|
| dnm2-related intermediate charcot-marie-tooth neuropathy |
|
|
Search MIR638 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR638
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR638 Gene
Publications for MIR638 Gene
- MicroRNA-638 inhibits cell growth and tubule formation by suppressing VEGFA expression in human Ewing sarcoma cells. (PMID: 29263143) Zhou X … Zhang Z (Bioscience reports 2018) 3 58
- Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma. (PMID: 29278659) Shi M … Lu XJ (Journal of cellular biochemistry 2018) 3 58
- hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. (PMID: 30010402) Chen Z … Duan X (DNA and cell biology 2018) 3 58
- Loss of miR-638 promotes invasion and epithelial-mesenchymal transition by targeting SOX2 in hepatocellular carcinoma. (PMID: 27878280) Zhang Y … Dong L (Oncology reports 2017) 3 58
- Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells. (PMID: 28412359) Zhao G … Wang T (Biochemical and biophysical research communications 2017) 3 58
ExternalLinks
Products for MIR638 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR638
- Origene Custom Protein Services for MIR638
- Browse OriGene Inhibitory RNA Products For MIR638
- OriGene qPCR primer pairs for MIR638
- Browse CRISPR knockouts for MIR638
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR638
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR638
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR638
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR638
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR638
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR638
Sources for MIR638 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind