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Aliases for MIR638 Gene

Subcategory (RNA class) for MIR638 Gene


Quality Score for this RNA gene is


Aliases for MIR638 Gene

  • MicroRNA 638 2 3 5
  • Hsa-Mir-638 3
  • MIRN638 3

External Ids for MIR638 Gene

ORGUL Members for MIR638 Gene

Previous HGNC Symbols for MIR638 Gene

  • MIRN638

Previous GeneCards Identifiers for MIR638 Gene

  • GC19U901002
  • GC19P010829

Summaries for MIR638 Gene

Entrez Gene Summary for MIR638 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR638 Gene

MIR638 (MicroRNA 638) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR638 include Systemic Lupus Erythematosus and Dnm2-Related Intermediate Charcot-Marie-Tooth Neuropathy.

Additional gene information for MIR638 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR638 Gene

Genomics for MIR638 Gene

GeneHancer (GH) Regulatory Elements for MIR638 Gene

Promoters and enhancers for MIR638 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010717 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 +0.6 608 4 MTA3 ZFX SP1 CC2D1A CTCF ELF3 SIX5 CBFA2T2 NKRF POLR2A DNM2 GC19P010718 GC19P010719 MIR638 KRI1 ILF3 EIF3G PPAN FBXL12 TIMM29
GH19J010758 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 12 +44.8 44757 8.9 ZNF652 SP1 ELF3 ZKSCAN8 MNT NKRF ZNF121 CEBPG RERE ZNF384 MIR199A1 SLC44A2 MIR638 DNM2 KRI1 CDKN2D SMARCA4 MIR4748 PIR47140
GH19J010757 Enhancer 0.7 ENCODE dbSUPER 12 +39.8 39757 0 IKZF1 ZNF512 ZNF366 ZNF398 MIR199A1 MIR638 DNM2 MIR4748 PIR47140
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR638 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR638 Gene

Genomic Locations for MIR638 Gene
100 bases
Plus strand
100 bases
Plus strand

Genomic View for MIR638 Gene

Genes around MIR638 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR638 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR638 Gene

Proteins for MIR638 Gene

Post-translational modifications for MIR638 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR638 Gene

Domains & Families for MIR638 Gene

Gene Families for MIR638 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR638: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR638 Gene

Function for MIR638 Gene

Gene Ontology (GO) - Molecular Function for MIR638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23554459
genes like me logo Genes that share ontologies with MIR638: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR638 Gene

Localization for MIR638 Gene

Gene Ontology (GO) - Cellular Components for MIR638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23554459
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR638: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR638 Gene

Pathways & Interactions for MIR638 Gene

PathCards logo

SuperPathways for MIR638 Gene

No Data Available

Interacting Proteins for MIR638 Gene

Gene Ontology (GO) - Biological Process for MIR638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0048008 platelet-derived growth factor receptor signaling pathway IDA 23554459
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IDA 23554459
GO:1904753 negative regulation of vascular associated smooth muscle cell migration IDA 23554459
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA 23554459
genes like me logo Genes that share ontologies with MIR638: view

No data available for Pathways by source and SIGNOR curated interactions for MIR638 Gene

Drugs & Compounds for MIR638 Gene

No Compound Related Data Available

Transcripts for MIR638 Gene

mRNA/cDNA for MIR638 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR638 Gene

No ASD Table

Relevant External Links for MIR638 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR638 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR638 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR638 Gene:

genes like me logo Genes that share expression patterns with MIR638: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR638 Gene

Orthologs for MIR638 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR638 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
Species where no ortholog for MIR638 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR638 Gene

Gene Tree for MIR638 (if available)
Gene Tree for MIR638 (if available)

Paralogs for MIR638 Gene

No data available for Paralogs for MIR638 Gene

Variants for MIR638 Gene

Sequence variations from dbSNP and Humsavar for MIR638 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1555696272 uncertain-significance, DNM2-related intermediate Charcot-Marie-Tooth neuropathy 10,718,406(+) G/A non_coding_transcript_variant
rs534605878 likely-benign, DNM2-related intermediate Charcot-Marie-Tooth neuropathy 10,718,323(+) C/T upstream_transcript_variant
rs753599004 uncertain-significance, Centronuclear Myopathy, Dominant, Charcot-Marie-Tooth, Intermediate 10,718,224(+) G/A/C/T upstream_transcript_variant
rs759919549 likely-benign, DNM2-related intermediate Charcot-Marie-Tooth neuropathy, not specified 10,718,332(+) C/T upstream_transcript_variant
rs774962668 uncertain-significance, DNM2-related intermediate Charcot-Marie-Tooth neuropathy 10,718,325(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR638 Gene

Variant ID Type Subtype PubMed ID
nsv1061882 CNV gain 25217958
nsv1160584 CNV deletion 26073780
nsv1160585 CNV deletion 26073780
nsv833745 CNV loss 17160897
nsv833746 CNV loss 17160897

Additional Variant Information for MIR638 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR638 Gene

Disorders for MIR638 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR638 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
dnm2-related intermediate charcot-marie-tooth neuropathy
  • charcot-marie-tooth disease, dominant intermediate b
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR638

genes like me logo Genes that share disorders with MIR638: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR638 Gene

Publications for MIR638 Gene

  1. MicroRNA-638 inhibits cell growth and tubule formation by suppressing VEGFA expression in human Ewing sarcoma cells. (PMID: 29263143) Zhou X … Zhang Z (Bioscience reports 2018) 3 58
  2. Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma. (PMID: 29278659) Shi M … Lu XJ (Journal of cellular biochemistry 2018) 3 58
  3. hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. (PMID: 30010402) Chen Z … Duan X (DNA and cell biology 2018) 3 58
  4. Loss of miR-638 promotes invasion and epithelial-mesenchymal transition by targeting SOX2 in hepatocellular carcinoma. (PMID: 27878280) Zhang Y … Dong L (Oncology reports 2017) 3 58
  5. Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells. (PMID: 28412359) Zhao G … Wang T (Biochemical and biophysical research communications 2017) 3 58

Products for MIR638 Gene

Sources for MIR638 Gene

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