microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR637 Gene

Subcategory (RNA class) for MIR637 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR637 Gene

  • MicroRNA 637 2 3 5
  • Hsa-Mir-637 2 3
  • Hsa-MiR-637 163 173
  • MIR637 2 5
  • MIMAT0003307 50
  • MI0003652 50
  • MIRN637 3

External Ids for MIR637 Gene

Previous HGNC Symbols for MIR637 Gene

  • MIRN637

Previous GeneCards Identifiers for MIR637 Gene

  • GC19M003913

Summaries for MIR637 Gene

Entrez Gene Summary for MIR637 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR637 Gene

MIR637 (MicroRNA 637) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR637 include Squamous Cell Carcinoma, Head And Neck and Systemic Lupus Erythematosus. Among its related pathways are Bladder cancer and Apoptotic execution phase.

Additional gene information for MIR637 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR637 Gene

Genomics for MIR637 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR637 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J003961 Enhancer 0.3 dbSUPER 600.7 +0.1 61 0.8 RBFOX2 MIR637 DAPK3 HSALNG0123318 NMRK2
GH19J003175 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 +782.8 782790 6.2 IKZF1 POLR2A BACH1 JUND FOXA1 LARP7 MTA2 ZIC2 IKZF2 TRIM22 NCLN SF3A2 GNA15 APBA3 S1PR4 CACTIN-AS1 ENSG00000267139 GNA11 CACTIN ENSG00000268670
GH19J003849 Enhancer 0.6 ENCODE 11.9 +112.2 112154 0.2 CTCF JUND REST RAD21 SCRT2 GATAD2A SMC3 AFF1 MAZ DEK ATCAY MIR637 DAPK3 EEF2 RF00017-2750 ZFR2 RF00017-2749 MATK
GH19J003999 Enhancer 0.6 Ensembl 11.8 -38.6 -38589 0.6 ZBTB33 RCOR2 ZKSCAN8 CTCF SAP130 RAD21 ZSCAN16 KDM1A ZBTB40 MNT piR-31432-318 piR-46662-316 piR-55627-055 DAPK3 MIR637 ATCAY PIAS4 lnc-EEF2-3 EEF2
GH19J004001 Enhancer 0.2 Ensembl 11.8 -39.8 -39789 0.2 DAPK3 MIR637 ATCAY PIAS4 piR-31432-318 lnc-EEF2-3 EEF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR637 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR637 Gene

Genomic Locations for MIR637 Gene
chr19:3,961,414-3,961,512
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand
chr19:3,961,412-3,961,510
(GRCh37/hg19)
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR637 Gene

Genes around MIR637 on UCSC Golden Path with GeneCards custom track
MIR637 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR637 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR637 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR637 Gene

Proteins for MIR637 Gene

Post-translational modifications for MIR637 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR637 Gene

Domains & Families for MIR637 Gene

Gene Families for MIR637 Gene

HGNC:
genes like me logo Genes that share domains with MIR637: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR637 Gene

Function for MIR637 Gene

Phenotypes From GWAS Catalog for MIR637 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR637 Gene

Localization for MIR637 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR637 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR637 Gene

Pathways & Interactions for MIR637 Gene

genes like me logo Genes that share pathways with MIR637: view

Pathways by source for MIR637 Gene

Gene Ontology (GO) - Biological Process for MIR637 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR637 Gene

Drugs & Compounds for MIR637 Gene

No Compound Related Data Available

Transcripts for MIR637 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR637 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075AC40_9606 precursor_RNA 99 4

HGNC: 32893,

RefSeq: NR_030367,

Ensembl: ENST00000385000 (view in UCSC) ,

miRBase: MI0003652,

URS000075EF97_9606 miRNA 24 4

RefSeq: NR_030367,

LncBase: hsa-miR-637,

miRBase: MIMAT0003307,

TarBase: hsa-miR-637,

MIR637 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR637 Gene

No ASD Table

Relevant External Links for MIR637 Gene

GeneLoc Exon Structure for
MIR637

No data available for mRNA/cDNA for MIR637 Gene

Expression for MIR637 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR637 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR637

genes like me logo Genes that share expression patterns with MIR637: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR637 Gene

Orthologs for MIR637 Gene

Evolution for MIR637 Gene

ENSEMBL:
Gene Tree for MIR637 (if available)
TreeFam:
Gene Tree for MIR637 (if available)

No data available for Orthologs for MIR637 Gene

Paralogs for MIR637 Gene

No data available for Paralogs for MIR637 Gene

Variants for MIR637 Gene

Additional dbSNP identifiers (rs#s) for MIR637 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR637 Gene

Variant ID Type Subtype PubMed ID
nsv833715 CNV loss 17160897
nsv953949 CNV deletion 24416366

Additional Variant Information for MIR637 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR637

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR637 Gene

Disorders for MIR637 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR637 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR637

genes like me logo Genes that share disorders with MIR637: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR637 Gene

Publications for MIR637 Gene

  1. Long non-coding RNA LINC00473 promotes glioma cells proliferation and invasion by impairing miR-637/CDK6 axis. (PMID: 31561732) Zhang Q … Song L (Artificial cells, nanomedicine, and biotechnology 2019) 3
  2. LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer. (PMID: 30267804) Wang L … Zhang B (The international journal of biochemistry & cell biology 2019) 3
  3. circHIPK3 promotes oxaliplatin-resistance in colorectal cancer through autophagy by sponging miR-637. (PMID: 31631038) Zhang Y … Zhang X (EBioMedicine 2019) 3
  4. Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis. (PMID: 30945557) Zhang M … Lou G (Artificial cells, nanomedicine, and biotechnology 2019) 3
  5. LINC01234 facilitates growth and invasiveness of oral squamous cell carcinoma through regulating the miR-637/NUPR1 axis. (PMID: 31590125) Huang W … Peng X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3

Products for MIR637 Gene

Sources for MIR637 Gene