Aliases for MIR636 Gene
Subcategory (RNA class) for MIR636 Gene
miRNA
Quality Score for this RNA gene is
8
External Ids for MIR636 Gene
- HGNC: 32892
- Entrez Gene: 693221
- Ensembl: ENSG00000283805
- miRBase: hsa-mir-636
ORGUL Members for MIR636 Gene
Previous HGNC Symbols for MIR636 Gene
- MIRN636
Previous GeneCards Identifiers for MIR636 Gene
- GC17M072245
- GC17M074732
- GC17M076737
- GC17M076738
Summaries for MIR636 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR636 Gene
MIR636 (MicroRNA 636) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination.
fRNAdb sequence ontologies for MIR636 Gene
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR636 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR636 Gene
Genomics for MIR636 Gene
GeneHancer (GH) Regulatory Elements for MIR636 Gene
Promoters and enhancers for MIR636 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17I076733 | Promoter/Enhancer | 3 | UCNEbase EPDnew Ensembl ENCODE dbSUPER | 550.8 | -0.7 | -711 | 7.8 | CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 | SRSF2 MFSD11 MIR636 UNK ENSG00000267342 TRIM65 ENSG00000266980 SEPT9 ENSG00000267546 METTL23 | |
| GH17I076772 | Enhancer | 0.8 | Ensembl ENCODE | 11.7 | -36.5 | -36500 | 1.8 | KLF1 SP3 SP2 KLF17 ZFP69B ZNF664 ZNF335 JUND POLR2A RCOR1 | SRSF2 MFSD11 MIR636 JMJD6 METTL23 UBALD2 GC17P076792 RNU6-97P |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR636 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR636 Gene
Genomic Locations for MIR636 Gene
- chr17:76,736,450-76,736,548
- (GRCh38/hg38)
- Size:
- 99 bases
- Orientation:
- Minus strand
- chr17:74,732,532-74,732,630
- (GRCh37/hg19)
Genomic View for MIR636 Gene
Genes around MIR636 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Ensembl
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
MIR636 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR636 Gene
ORGUL Member Location for MIR636 Gene
Proteins for MIR636 Gene
Post-translational modifications for MIR636 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR636
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR636
- Origene Custom Protein Services for MIR636
- Search GeneTex for Proteins for MIR636
No data available for DME Specific Peptides for MIR636 Gene
Domains & Families for MIR636 Gene
Gene Families for MIR636 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR636 Gene
Function for MIR636 Gene
Phenotypes From GWAS Catalog for MIR636 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR636
-
- Search ViGene Biosciences for MIR636
CRISPR Products
- Browse CRISPR knockouts for MIR636
- Applied Biological Materials CRISPR for MIR636
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR636
Clone Products
- GenScript: Custom all cDNA clones Services for MIR636
- VectorBuilder custom plasmid, inducible vectors for MIR636
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR636
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR636
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR636 Gene
Localization for MIR636 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR636 Gene
Pathways & Interactions for MIR636 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | RNA Polymerase II Transcription Termination | ||
| 3 | Transport of Mature Transcript to Cytoplasm | ||
| 4 | Gene Expression |
.48
|
|
| 5 | mRNA Splicing - Minor Pathway | ||
Pathways by source for MIR636 Gene
1 BioSystems pathway for MIR636 Gene
11 Reactome pathways for MIR636 Gene
Interacting Proteins for MIR636 Gene
No data available for SIGNOR curated interactions for MIR636 Gene
Transcripts for MIR636 Gene
fRNAdb Secondary structures for MIR636 Gene
mRNA/cDNA for MIR636 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR636
- Applied Biological Materials CRISPR for MIR636
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR636
Clone Products
- GenScript: Custom all cDNA clones Services for MIR636
- VectorBuilder custom plasmid, inducible vectors for MIR636
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR636
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR636
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR636 Gene
mRNA differential expression in normal tissues according to GTEx for MIR636 Gene
This gene is overexpressed in Testis (x6.5).
NURSA nuclear receptor signaling pathways regulating expression of MIR636 Gene:
MIR636Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR636 Gene
Orthologs for MIR636 Gene
No data available for Orthologs for MIR636 Gene
Paralogs for MIR636 Gene
No data available for Paralogs for MIR636 Gene
Variants for MIR636 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1064796272 | uncertain-significance, not specified | 76,736,272(-) | GGACCTGGACC/GGACC | downstream_transcript_variant | |
| rs1000409899 | -- | 76,736,096(-) | C/G | downstream_transcript_variant | |
| rs1000715601 | -- | 76,736,918(-) | G/A | upstream_transcript_variant | |
| rs1002118252 | -- | 76,737,983(-) | C/G/T | upstream_transcript_variant | |
| rs1003296233 | -- | 76,737,522(-) | GGAGGGAGGG/GGAGGG | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1110921 | OTHER | inversion | 24896259 |
| nsv833550 | CNV | loss | 17160897 |
Additional Variant Information for MIR636 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR636
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR636 Gene
Disorders for MIR636 Gene
Additional Disease Information for MIR636
No disorders were found for MIR636 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR636 Gene
Publications for MIR636 Gene
- The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
- Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma. (PMID: 23306701) Jang JY … Kim CW (Experimental & molecular medicine 2013) 3 58
- Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X … Wong TY (PloS one 2013) 3 58
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
Products for MIR636 Gene
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR636
- VectorBuilder custom plasmid, inducible vectors for MIR636
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR636
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR636
- Search GeneTex for Proteins for MIR636
- Search ViGene Biosciences for MIR636
Sources for MIR636 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems