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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR636 (MicroRNA 636) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and mRNA Splicing - Minor Pathway.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J076734 | Promoter/Enhancer | 2.6 | UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.7 | -711 | 7.8 | ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 ZNF512 | SRSF2 MFSD11 NONHSAG022835.2 MN297510 MIR636 lnc-JMJD6-1 UNK ENSG00000267342 TRIM65 ENSG00000266980 | |
GH17J076772 | Enhancer | 0.8 | Ensembl ENCODE | 12 | -36.6 | -36552 | 2.6 | SP2 ZNF335 RCOR1 ZFP69B KLF17 CTCF ZNF664 KLF10 SP3 KLF1 | METTL23 SRSF2 MFSD11 MIR636 JMJD6 UBALD2 MN297511 piR-52079-083 NONHSAG022835.2 MGAT5B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
2 | Cleavage of Growing Transcript in the Termination Region | ||
3 | Transport of Mature Transcript to Cytoplasm | ||
4 | Gene Expression |
.48
|
|
5 | mRNA Splicing - Minor Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000062E57E_9606 | precursor_RNA | 99 | 5 |
HGNC: 32892, RefSeq: NR_030366, Ensembl: ENST00000384825 (view in UCSC) , miRBase: MI0003651, Rfam: RF01008, |
URS000075A79D_9606 | miRNA | 23 | 3 |
RefSeq: NR_030366, miRBase: MIMAT0003306, TarBase: hsa-miR-636, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1110921 | OTHER | inversion | 24896259 |
nsv833550 | CNV | loss | 17160897 |
No disorders were found for MIR636 Gene.