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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR636 Gene
Subcategory (RNA class) for MIR636 Gene
miRNA
Number of RNA Genes sources:
3 / 17
Aliases for MIR636 Gene
External Ids for MIR636 Gene
- HGNC: 32892
- Entrez Gene: 693221
- Ensembl: ENSG00000283805
- miRBase: hsa-mir-636
Previous HGNC Symbols for MIR636 Gene
- MIRN636
Previous GeneCards Identifiers for MIR636 Gene
- GC17M072245
- GC17M074732
- GC17M076737
- GC17M076738
Summaries for MIR636 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR636 Gene
MIR636 (MicroRNA 636) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and mRNA Splicing - Minor Pathway.
Rfam classification for MIR636 Gene
-
microRNA mir-636
Additional gene information for MIR636 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR636 Gene
Genomics for MIR636 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR636 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J076734 | Promoter/Enhancer | 2.6 | UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.7 | -711 | 7.8 | ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 ZNF512 | SRSF2 MFSD11 NONHSAG022835.2 MN297510 MIR636 lnc-JMJD6-1 UNK ENSG00000267342 TRIM65 ENSG00000266980 | |
| GH17J076772 | Enhancer | 0.8 | Ensembl ENCODE | 12 | -36.6 | -36552 | 2.6 | SP2 ZNF335 RCOR1 ZFP69B KLF17 CTCF ZNF664 KLF10 SP3 KLF1 | METTL23 SRSF2 MFSD11 MIR636 JMJD6 UBALD2 MN297511 piR-52079-083 NONHSAG022835.2 MGAT5B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR636 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR636 Gene
Genomic Locations for MIR636 Gene
- chr17:76,736,450-76,736,548
- (GRCh38/hg38)
- Size:
- 99 bases
- Orientation:
- Minus strand
- chr17:74,732,532-74,732,630
- (GRCh37/hg19)
- Size:
- 99 bases
- Orientation:
- Minus strand
Genomic View for MIR636 Gene
Genes around MIR636 on UCSC Golden Path with GeneCards custom track
MIR636 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
MIR636 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR636 Gene
Proteins for MIR636 Gene
Post-translational modifications for MIR636 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR636
- Origene Custom Protein Services for MIR636
No data available for DME Specific Peptides for MIR636 Gene
Domains & Families for MIR636 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR636 Gene
Function for MIR636 Gene
Phenotypes From GWAS Catalog for MIR636 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR636 - Select products 50% OFF >
- * MIR636 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR636
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR636 - Select products 50% OFF >
- * MIR636 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR636 Gene
Localization for MIR636 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR636 Gene
Pathways & Interactions for MIR636 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | Cleavage of Growing Transcript in the Termination Region | ||
| 3 | Transport of Mature Transcript to Cytoplasm | ||
| 4 | Gene Expression |
.48
|
|
| 5 | mRNA Splicing - Minor Pathway | ||
Pathways by source for MIR636 Gene
1 BioSystems pathway for MIR636 Gene
11 Reactome pathways for MIR636 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IEA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR636 Gene
Transcripts for MIR636 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR636 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000062E57E_9606 | precursor_RNA | 99 | 5 |
HGNC: 32892, RefSeq: NR_030366, Ensembl: ENST00000384825 (view in UCSC) , miRBase: MI0003651, Rfam: RF01008, |
| URS000075A79D_9606 | miRNA | 23 | 3 |
RefSeq: NR_030366, miRBase: MIMAT0003306, TarBase: hsa-miR-636, |
MIR636 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR636 - Select products 50% OFF >
- * MIR636 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR636
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR636 - Select products 50% OFF >
- * MIR636 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR636 Gene
- GeneLoc Exon Structure for
- MIR636
No data available for mRNA/cDNA for MIR636 Gene
Expression for MIR636 Gene
mRNA differential expression in normal tissues according to GTEx for MIR636 Gene
This gene is overexpressed in Testis (x6.5).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR636
Primer Products
-
OriGene qPCR primer pairs for MIR636
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR636 Gene
Orthologs for MIR636 Gene
No data available for Orthologs for MIR636 Gene
Paralogs for MIR636 Gene
No data available for Paralogs for MIR636 Gene
Variants for MIR636 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1110921 | OTHER | inversion | 24896259 |
| nsv833550 | CNV | loss | 17160897 |
Additional Variant Information for MIR636 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR636
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR636 Gene
Disorders for MIR636 Gene
Additional Disease Information for MIR636
No disorders were found for MIR636 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR636 Gene
Publications for MIR636 Gene
- Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
- Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X … Wong TY (PloS one 2013) 3
- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma. (PMID: 23306701) Jang JY … Kim CW (Experimental & molecular medicine 2013) 3
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
ExternalLinks
Products for MIR636 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR636
- Origene Custom Protein Services for MIR636
- Browse OriGene Inhibitory RNA Products For MIR636
- OriGene qPCR primer pairs for MIR636
- Browse CRISPR knockouts for MIR636
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR636
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR636
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR636
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR636
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR636
Sources for MIR636 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB