MIR636 Gene (RNA Gene)

MicroRNA 636

GC17M076736
GIFtS:
16
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR636 Gene

Data sources for MIR636 Gene:

Subcategory (RNA class) for MIR636 Gene

miRNA

Aliases for MIR636 Gene

External Ids for MIR636 Gene

Previous HGNC Symbols for MIR636 Gene

  • MIRN636

Previous GeneCards Identifiers for MIR636 Gene

  • GC17M072245
  • GC17M074732
  • GC17M076737
  • GC17M076738

Summaries for MIR636 Gene

Entrez Gene Summary for MIR636 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR636 Gene

MIR636 (MicroRNA 636) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination.

Rfam classification for MIR636 Gene

Additional gene information for MIR636 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR636 Gene

Genomics for MIR636 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR636 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J076734 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -0.7 -711 7.8 CHD2 ZBTB10 BCL11A SP1 MXD4 FEZF1 CEBPA SIX5 NR2C1 MNT SRSF2 MFSD11 MN297510 MIR636 NONHSAG022835.2 lnc-JMJD6-1 UNK ENSG00000267342 TRIM65 ENSG00000266980
GH17J076772 Promoter/Enhancer 0.9 Ensembl ENCODE 11.7 -36.5 -36500 1.8 SP2 JUND CTCF ZNF664 RCOR1 ZFP69B KLF1 POLR2A KLF10 MLLT1 MFSD11 MIR636 SRSF2 JMJD6 METTL23 UBALD2 MN297511 HSALNG0118871 NONHSAG022835.2 MGAT5B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR636 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR636 Gene

Latest Assembly
chr17:76,736,450-76,736,548
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand

Previous Assembly
chr17:74,732,532-74,732,630
(GRCh37/hg19 by Entrez Gene)
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR636 Gene

Genes around MIR636 on UCSC Golden Path with GeneCards custom track
MIR636 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR636 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR636 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR636 Gene

Proteins for MIR636 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

Post-translational modifications for MIR636 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR636 Gene

Domains & Families for MIR636 Gene

Gene Families for MIR636 Gene

HGNC:
genes like me logo Genes that share domains with MIR636: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR636 Gene

Function for MIR636 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for MIR636 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR636 Gene

Localization for MIR636 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR636 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR636 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR636: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR636 Gene

Pathways & Interactions for MIR636 Gene

genes like me logo Genes that share pathways with MIR636: view

Pathways by source for MIR636 Gene

1 BioSystems pathway for MIR636 Gene

Gene Ontology (GO) - Biological Process for MIR636 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR636: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR636 Gene

Drugs & Compounds for MIR636 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for MIR636 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR636 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000062E57E_9606 pre_miRNA 99 4

RefSeq: NR_030366,

Ensembl: ENST00000384825 (view in UCSC) ,

miRBase: MI0003651,

Rfam: RF01008,

URS000075A79D_9606 miRNA 23 3

RefSeq: NR_030366,

miRBase: MIMAT0003306,

TarBase: hsa-miR-636,

URS0001BC5669_9606 pre_miRNA 99 1

Rfam: RF01008,

MIR636 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

CRISPR products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MIR636 Gene

No ASD Table

Relevant External Links for MIR636 Gene

GeneLoc Exon Structure for
MIR636

No data available for mRNA/cDNA for MIR636 Gene

Expression for MIR636 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR636 Gene

mRNA expression in normal human tissues for MIR636 Gene
mRNA expression by GTEx for MIR636 Gene

mRNA differential expression in normal tissues according to GTEx for MIR636 Gene

This gene is overexpressed in Testis (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR636

genes like me logo Genes that share expression patterns with MIR636: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR636 Gene

Orthologs for MIR636 Gene

Evolution for MIR636 Gene

ENSEMBL:
Gene Tree for MIR636 (if available)
TreeFam:
Gene Tree for MIR636 (if available)

No data available for Orthologs for MIR636 Gene

Paralogs for MIR636 Gene

No data available for Paralogs for MIR636 Gene

Variants for MIR636 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR636 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR636 Gene

Variant ID Type Subtype PubMed ID
nsv1110921 OTHER inversion 24896259
nsv833550 CNV loss 17160897

Additional Variant Information for MIR636 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR636

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR636 Gene

Disorders for MIR636 Gene

Additional Disease Information for MIR636

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR636 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR636 Gene

Publications for MIR636 Gene

  1. CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9. (PMID: 31821171) He Q … Lin T (Aging 2019) 3
  2. miR-636: A Newly-Identified Actor for the Regulation of Pulmonary Inflammation in Cystic Fibrosis. (PMID: 31803183) Bardin P … Tabary O (Frontiers in immunology 2019) 3
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  4. Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X … Wong TY (PloS one 2013) 3
  5. ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma. (PMID: 23306701) Jang JY … Kim CW (Experimental & molecular medicine 2013) 3

ExternalLinks

View latest publications for MIR636 gene in Mastermind

Products for MIR636 Gene

Sources for MIR636 Gene