microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR636 Gene

Subcategory (RNA class) for MIR636 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR636 Gene

  • MicroRNA 636 2 3 5
  • MIMAT0003306 51
  • Hsa-Mir-636 3
  • Hsa-MiR-636 177
  • MI0003651 51
  • MIRN636 3
  • RF01008 172
  • MIR636 2

External Ids for MIR636 Gene

Previous HGNC Symbols for MIR636 Gene

  • MIRN636

Previous GeneCards Identifiers for MIR636 Gene

  • GC17M072245
  • GC17M074732
  • GC17M076737
  • GC17M076738

Summaries for MIR636 Gene

Entrez Gene Summary for MIR636 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR636 Gene

MIR636 (MicroRNA 636) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm.

Rfam classification for MIR636 Gene

Additional gene information for MIR636 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR636 Gene

Genomics for MIR636 Gene

GeneHancer (GH) Regulatory Elements for MIR636 Gene

Promoters and enhancers for MIR636 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076734 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.7 -711 7.8 EP300 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 MYC POLR2G SRSF2 MFSD11 MIR636 NONHSAG022835.2 lnc-JMJD6-1 UNK ENSG00000267342 ENSG00000266980 METTL23 ENSG00000267546
GH17J076772 Enhancer 0.8 Ensembl ENCODE 12 -36.6 -36552 2.6 SP2 FOS ZNF335 KLF17 RCOR1 ZNF664 CTCF POLR2A ZFP69B KLF1 METTL23 MFSD11 MIR636 SRSF2 JMJD6 UBALD2 lnc-SRSF2-1 piR-52079-083 NONHSAG022835.2 SNHG16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR636 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR636 Gene

Genomic Locations for MIR636 Gene
chr17:76,736,450-76,736,548
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand
chr17:74,732,532-74,732,630
(GRCh37/hg19)
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR636 Gene

Genes around MIR636 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR636 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR636 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR636 Gene

Proteins for MIR636 Gene

Post-translational modifications for MIR636 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR636 Gene

Domains & Families for MIR636 Gene

Gene Families for MIR636 Gene

HGNC:
genes like me logo Genes that share domains with MIR636: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR636 Gene

Function for MIR636 Gene

Phenotypes From GWAS Catalog for MIR636 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR636 Gene

Localization for MIR636 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR636 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR636 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR636: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR636 Gene

Pathways & Interactions for MIR636 Gene

genes like me logo Genes that share pathways with MIR636: view

Pathways by source for MIR636 Gene

;

Gene Ontology (GO) - Biological Process for MIR636 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR636 Gene

Drugs & Compounds for MIR636 Gene

No Compound Related Data Available

Transcripts for MIR636 Gene

mRNA/cDNA for MIR636 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR636 Gene

No ASD Table

Relevant External Links for MIR636 Gene

GeneLoc Exon Structure for
MIR636

Expression for MIR636 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR636 Gene

mRNA differential expression in normal tissues according to GTEx for MIR636 Gene

This gene is overexpressed in Testis (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR636

genes like me logo Genes that share expression patterns with MIR636: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR636 Gene

Orthologs for MIR636 Gene

Evolution for MIR636 Gene

ENSEMBL:
Gene Tree for MIR636 (if available)
TreeFam:
Gene Tree for MIR636 (if available)

No data available for Orthologs for MIR636 Gene

Paralogs for MIR636 Gene

No data available for Paralogs for MIR636 Gene

Variants for MIR636 Gene

Additional dbSNP identifiers (rs#s) for MIR636 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR636 Gene

Variant ID Type Subtype PubMed ID
nsv1110921 OTHER inversion 24896259
nsv833550 CNV loss 17160897

Additional Variant Information for MIR636 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR636

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR636 Gene

Disorders for MIR636 Gene

Additional Disease Information for MIR636

No disorders were found for MIR636 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR636 Gene

Publications for MIR636 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 54
  2. Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X … Wong TY (PloS one 2013) 3 54
  3. ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma. (PMID: 23306701) Jang JY … Kim CW (Experimental & molecular medicine 2013) 3 54
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 54
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR636 Gene

Sources for MIR636 Gene