microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR633 Gene

Data sources for MIR633 Gene:

RNA type for MIR633 Gene

miRNA

Aliases for MIR633 Gene

External Ids for MIR633 Gene

Previous HGNC Symbols for MIR633 Gene

  • MIRN633

Previous GeneCards Identifiers for MIR633 Gene

  • GC17P058376
  • GC17P061021

Summaries for MIR633 Gene

Entrez Gene Summary for MIR633 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR633 Gene

MIR633 (MicroRNA 633) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR633 Gene

Additional gene information for MIR633 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR633 Gene

Genomics for MIR633 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR633 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR633 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR633 Gene

Latest Assembly
chr17:62,944,215-62,944,312
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand

Previous Assembly
chr17:61,021,576-61,021,673
(GRCh37/hg19 by Entrez Gene)
Size:
98 bases
Orientation:
Plus strand

chr17:61,021,576-61,021,673
(GRCh37/hg19 by Ensembl)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR633 Gene

Genes around MIR633 on UCSC Golden Path with GeneCards custom track
MIR633 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR633 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR633 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR633 Gene

Proteins for MIR633 Gene

Post-translational modifications for MIR633 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR633 Gene

Domains & Families for MIR633 Gene

Gene Families for MIR633 Gene

HGNC:
genes like me logo Genes that share domains with MIR633: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR633 Gene

Function for MIR633 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR633 Gene

Localization for MIR633 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR633 Gene

Pathways & Interactions for MIR633 Gene

PathCards logo

SuperPathways for MIR633 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR633 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR633: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR633 Gene

Drugs & Compounds for MIR633 Gene

No Compound Related Data Available

Transcripts for MIR633 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR633 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000678203_9606 pre_miRNA 98 4

RefSeq: NR_030363,

Ensembl: ENST00000384821 (view in UCSC) ,

miRBase: MI0003648,

Rfam: RF01028,

URS000075EE25_9606 miRNA 23 2

RefSeq: NR_030363,

miRBase: MIMAT0003303,

URS0001BC2A66_9606 pre_miRNA 98 1

Rfam: RF01028,

MIR633 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR633 Gene

No ASD Table

Relevant External Links for MIR633 Gene

GeneLoc Exon Structure for
MIR633

No data available for mRNA/cDNA for MIR633 Gene

Expression for MIR633 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR633 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR633

genes like me logo Genes that share expression patterns with MIR633: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR633 Gene

Orthologs for MIR633 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR633 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-633 30
  • 98 (a)
OneToOne
Species where no ortholog for MIR633 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR633 Gene

ENSEMBL:
Gene Tree for MIR633 (if available)
TreeFam:
Gene Tree for MIR633 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR633

Paralogs for MIR633 Gene

No data available for Paralogs for MIR633 Gene

Variants for MIR633 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR633 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR633 Gene

Variant ID Type Subtype PubMed ID
dgv5741n54 CNV loss 21841781
esv3640980 CNV loss 21293372
nsv457865 CNV loss 19166990
nsv575846 CNV loss 21841781

Additional Variant Information for MIR633 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR633
Leiden Open Variation Database (LOVD)
MIR633

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR633 Gene

Disorders for MIR633 Gene

Additional Disease Information for MIR633

No disorders were found for MIR633 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR633 Gene

Publications for MIR633 Gene

  1. Foxo3a-dependent miR-633 regulates chemotherapeutic sensitivity in gastric cancer by targeting Fas-associated death domain. (PMID: 30628514) Pang X … Wang J (RNA biology 2019) 3
  2. Downregulation of miR-633 activated AKT/mTOR pathway by targeting AKT1 in lupus CD4+ T cells. (PMID: 30760089) Chen S … Xu J (Lupus 2019) 3
  3. Screening of miRNAs in human follicular fluid reveals an inverse relationship between microRNA-663b expression and blastocyst formation. (PMID: 29703434) Fu J … Sun XX (Reproductive biomedicine online 2018) 3
  4. The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2). (PMID: 23436656) Hu H … Lin L (The Journal of biological chemistry 2013) 3
  5. MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. (PMID: 22249270) Yi C … Yun JP (Oncogene 2012) 3

Products for MIR633 Gene

Sources for MIR633 Gene