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Aliases for MIR631 Gene

Subcategory (RNA class) for MIR631 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR631 Gene

  • MicroRNA 631 2 3 5
  • Hsa-Mir-631 3
  • MIRN631 3

External Ids for MIR631 Gene

Previous HGNC Symbols for MIR631 Gene

  • MIRN631

Previous GeneCards Identifiers for MIR631 Gene

  • GC15M073434
  • GC15M075645

Summaries for MIR631 Gene

Entrez Gene Summary for MIR631 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR631 Gene

MIR631 (MicroRNA 631) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Glycosaminoglycan metabolism and Metabolism.

fRNAdb sequence ontologies for MIR631 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR631 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR631 Gene

Genomics for MIR631 Gene

GeneHancer (GH) Regulatory Elements for MIR631 Gene

Promoters and enhancers for MIR631 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075646 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -295.9 -295886 7.1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SNX33 GC15P075650 IMP3 SIN3A MIR631 MAN2C1 ENSG00000260892
GH15I075637 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -285.8 -285803 4.5 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 ENSG00000275454 IMP3 MAN2C1 SNUPN ENSG00000203392 CSPG4 LOC441728 ENSG00000260274 COMMD4 SIN3A
GH15I075693 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.5 -342.2 -342217 5.4 ATF1 ARNT TCF12 GLIS2 GATA2 ZNF143 FOS ATF7 RUNX3 NCOA1 MIR631 LOC441728 ENSG00000261043 DNM1P35 SNX33 SCAMP5 CSPG4 ENSG00000203392
GH15I075711 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 8.3 -359.1 -359102 2.6 PKNOX1 INSM2 KLF17 ZNF76 SIN3A GLI4 ZNF2 ZNF335 GLIS2 EGR1 CSPG4 MAN2C1 ENSG00000203392 SIN3A ENSG00000260274 DNM1P35 FBXO22 ENSG00000261043 DNM1P34 MIR631
GH15I075842 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.9 -490.4 -490353 3.1 SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 SP3 SP5 UBE2Q2 SIN3A ENSG00000260274 MAN2C1 COMMD4 FBXO22 MIR631 SCAMP5 LOC101929439 RN7SL510P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR631 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR631 Gene

Genomic Locations for MIR631 Gene
chr15:75,353,611-75,353,685
(GRCh38/hg38)
Size:
75 bases
Orientation:
Minus strand
chr15:75,645,952-75,646,026
(GRCh37/hg19)

Genomic View for MIR631 Gene

Genes around MIR631 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR631 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR631 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR631 Gene

ORGUL Member Location for MIR631 Gene

ORGUL Member Location for MIR631 gene

Proteins for MIR631 Gene

Post-translational modifications for MIR631 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR631 Gene

Domains & Families for MIR631 Gene

Gene Families for MIR631 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR631: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR631 Gene

Function for MIR631 Gene

Phenotypes From GWAS Catalog for MIR631 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR631 Gene

Localization for MIR631 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR631 Gene

Pathways & Interactions for MIR631 Gene

genes like me logo Genes that share pathways with MIR631: view

Pathways by source for MIR631 Gene

Interacting Proteins for MIR631 Gene

Gene Ontology (GO) - Biological Process for MIR631 Gene

None

No data available for SIGNOR curated interactions for MIR631 Gene

Drugs & Compounds for MIR631 Gene

No Compound Related Data Available

Transcripts for MIR631 Gene

mRNA/cDNA for MIR631 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR631 Gene

No ASD Table

Relevant External Links for MIR631 Gene

GeneLoc Exon Structure for
MIR631
ECgene alternative splicing isoforms for
MIR631

Expression for MIR631 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR631 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR631 Gene:

MIR631
genes like me logo Genes that share expression patterns with MIR631: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR631 Gene

Orthologs for MIR631 Gene

Evolution for MIR631 Gene

ENSEMBL:
Gene Tree for MIR631 (if available)
TreeFam:
Gene Tree for MIR631 (if available)

No data available for Orthologs for MIR631 Gene

Paralogs for MIR631 Gene

No data available for Paralogs for MIR631 Gene

Variants for MIR631 Gene

Sequence variations from dbSNP and Humsavar for MIR631 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000890518 -- 75,355,155(-) C/G upstream_transcript_variant
rs1001128493 -- 75,354,867(-) G/A upstream_transcript_variant
rs1001424088 -- 75,353,534(-) A/C downstream_transcript_variant
rs1002122012 -- 75,354,141(-) G/A upstream_transcript_variant
rs1003984270 -- 75,355,395(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR631 Gene

Variant ID Type Subtype PubMed ID
dgv2621n100 CNV gain 25217958
esv2749894 CNV deletion 23290073
nsv1116463 OTHER inversion 24896259
nsv1615 CNV insertion 18451855
nsv951996 CNV deletion 24416366

Additional Variant Information for MIR631 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR631

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR631 Gene

Disorders for MIR631 Gene

Additional Disease Information for MIR631

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR631 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR631 Gene

Publications for MIR631 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  2. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  4. hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10. (PMID: 28000886) Xi H … Zhao LM (Oncology reports 2017) 3 58
  5. MiR-631/ZAP70: A novel axis in the migration and invasion of prostate cancer cells. (PMID: 26620225) Fu D … Jiang H (Biochemical and biophysical research communications 2016) 3 58

Products for MIR631 Gene

Sources for MIR631 Gene

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